Cell biology, ORAI1, Voltage-dependent calcium channel, NFAT and STIM2 are his primary areas of study. His work on Calcium signaling as part of general Cell biology study is frequently linked to Plasma membrane repair, bridging the gap between disciplines. Many of his studies on ORAI1 apply to Severe combined immunodeficiency as well.
His studies deal with areas such as Endocrinology and Membrane potential as well as Voltage-dependent calcium channel. Stefan Feske combines subjects such as Receptor, Transmembrane domain and Store-operated calcium entry with his study of STIM2. His Cytotoxic T cell research is multidisciplinary, incorporating elements of T cell, Endocytosis, Vesicle and Endosome.
His primary scientific interests are in Cell biology, ORAI1, STIM1, T cell and STIM2. His Cell biology research includes elements of NFAT, Immune system and Voltage-dependent calcium channel. His research integrates issues of Endocrinology, Store-operated calcium entry, Cancer research and Immunodeficiency in his study of ORAI1.
His STIM1 course of study focuses on Platelet and Integrin. Stefan Feske interconnects Cytotoxic T cell and Molecular biology in the investigation of issues within T cell. While the research belongs to areas of Immunology, Stefan Feske spends his time largely on the problem of Severe combined immunodeficiency, intersecting his research to questions surrounding ORAI2 Protein.
Stefan Feske mainly investigates Cell biology, Immune system, STIM1, STIM2 and ORAI1. The Cell biology study combines topics in areas such as T cell, TRPC1 and Transcription factor. In his work, Store-operated calcium entry is strongly intertwined with Homeostasis, which is a subfield of Transcription factor.
His STIM1 study is focused on Endoplasmic reticulum in general. The study incorporates disciplines such as Natural killer cell, Signal transduction and Dysplasia in addition to STIM2. His ORAI1 study deals with Autoimmunity intersecting with Lymphocyte and T cell mediated immunity.
His main research concerns Cell biology, ORAI1, STIM2, STIM1 and T cell. His Cell biology research includes themes of Inflammation and Immune system. ORAI1 is a subfield of Endoplasmic reticulum that Stefan Feske studies.
His study in STIM2 is interdisciplinary in nature, drawing from both Cytoplasm, Ryanodine receptor, Dysplasia, Immunology and FOXP3. Stefan Feske combines subjects such as Genetically engineered, Gene, Activator and Disease with his study of STIM1. His biological study spans a wide range of topics, including Transcription factor, NFAT and Function.
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A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Stefan Feske;Yousang Gwack;Murali Prakriya;Sonal Srikanth.
Orai1 is an essential pore subunit of the CRAC channel
Murali Prakriya;Stefan Feske;Yousang Gwack;Sonal Srikanth.
Calcium signalling in lymphocyte activation and disease.
Nature Reviews Immunology (2007)
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
Ping Chih Ho;Jessica Dauz Bihuniak;Andrew N. MacIntyre;Matthew Staron.
Gene regulation mediated by calcium signals in T lymphocytes.
Stefan Feske;Jena Giltnane;Ricardo Dolmetsch;Louis M. Staudt.
Nature Immunology (2001)
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.
Vigo Heissmeyer;Fernando Macián;Fernando Macián;Sin Hyeog Im;Sin Hyeog Im;Rajat Varma.
Nature Immunology (2004)
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance.
Masatsugu Oh-hora;Megumi Yamashita;Patrick G Hogan;Sonia Sharma.
Nature Immunology (2008)
STIM1 Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity
Capucine Picard;Christie Ann McCarl;Alexander Papolos;Sara Khalil.
The New England Journal of Medicine (2009)
Biochemical and functional characterization of Orai proteins.
Yousang Gwack;Sonal Srikanth;Stefan Feske;Fernando Cruz-Guilloty.
Journal of Biological Chemistry (2007)
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
Yousang Gwack;Sonia Sharma;Julie Nardone;Bogdan Tanasa.
Profile was last updated on December 6th, 2021.
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