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Biology and Biochemistry

D-Index
77
Citations
22118
World Ranking
4763
National Ranking
2306

Medicine

D-Index
77
Citations
22185
World Ranking
18418
National Ranking
9187

Overview

Heike Wulff is affiliated with the University of California, Davis in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, medicine, and neuroscience. Their research spans a range of topics that include ion channel regulation and function, neuroscience and neuropharmacology, neuroinflammation and neurodegeneration mechanisms, cardiac electrophysiology and arrhythmias, nicotinic acetylcholine receptors, receptor mechanisms and signaling, as well as adenosine and purinergic signaling.

Wulff's publication record features key recent papers such as "A non-hallucinogenic psychedelic analogue with therapeutic potential" (2020, Nature), "THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels" (2021, British Journal of Pharmacology), "The Concise Guide to PHARMACOLOGY 2023/24: Ion channels" (2023, British Journal of Pharmacology), "Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease" (2020, Journal of Clinical Investigation), and "An artificial intelligence accelerated virtual screening platform for drug discovery" (2024, Nature Communications).

Their research has been disseminated in several frequent publication venues, including:

  • Biophysical Journal
  • Frontiers in Pharmacology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The FASEB Journal
  • Alzheimer's & Dementia

Regarding collaborative efforts, Wulff has co-authored works with several frequent collaborators, such as:

  • Hai M. Nguyen
  • Vladimir Yarov-Yarovoy
  • Vikrant Singh
  • Heesung Shim
  • Yi-Je Chen

Their work covers various subfields, including molecular biology, neurology, cellular and molecular neuroscience, cardiology and cardiovascular medicine, and physiology.

Best Publications

  • International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels

    Aguan D. Wei;George A. Gutman;Richard W Aldrich;K. George Chandy

  • Voltage-gated potassium channels as therapeutic targets

    Heike Wulff;Neil A. Castle;Luis A. Pardo

  • Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: A potential immunosuppressant

    Heike Wulff;Mark J. Miller;Wolfram Hänsel;Stephan Grissmer

  • Ion Channels in Innate and Adaptive Immunity

    Stefan Feske;Heike Wulff;Edward Y Skolnik

  • Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

    Christine Beeton;Heike Wulff;Nathan E. Standifer;Philippe Azam

  • International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels : potassium channels

    George A. Gutman;K. George Chandy;John P. Adelman;Jayashree Aiyar

  • K+ channels as targets for specific immunomodulation.

    K. George Chandy;Heike Wulff;Christine Beeton;Michael Pennington

  • The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS

    Heike Wulff;Peter A. Calabresi;Rameeza Allie;Sung Yun

  • Up-regulation of the IKCa1 Potassium Channel during T-cell Activation MOLECULAR MECHANISM AND FUNCTIONAL CONSEQUENCES

    Sanjiv Ghanshani;Heike Wulff;Mark J. Miller;Heike Rohm

  • Selective blockade of T lymphocyte K+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

    Christine Beeton;Heike Wulff;Jocelyne Barbaria;Olivier Clot-Faybesse

  • A non-hallucinogenic psychedelic analogue with therapeutic potential

    Lindsay P. Cameron;Robert J. Tombari;Ju Lu;Alexander J. Pell

  • Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases

    Christine Beeton;Michael W. Pennington;Heike Wulff;Satendra Singh

  • Molecular Properties and Physiological Roles of Ion Channels in the Immune System

    Michael D. Cahalan;Heike Wulff;K. George Chandy

  • Amyloid-β protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity

    Izumi Maezawa;Pavel I. Zimin;Heike Wulff;Lee-Way Jin

  • Blockade of the Intermediate-Conductance Calcium-Activated Potassium Channel as a New Therapeutic Strategy for Restenosis

    Ralf Köhler;Heike Wulff;Ines Eichler;Marlene Kneifel

  • Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a New Activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the Endothelium-Derived Hyperpolarizing Factor Response and Lowers Blood Pressure

    Ananthakrishnan Sankaranarayanan;Girija Raman;Christoph Busch;Tim Schultz

  • The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans

    Kazuyoshi Toyama;Heike Wulff;K. George Chandy;Philippe Azam

  • Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension

    Sebastian Brähler;Anuradha Kaistha;Volker J. Schmidt;Stephanie E. Wölfle

  • Design of PAP-1, a Selective Small Molecule Kv1.3 Blocker, for the Suppression of Effector Memory T Cells in Autoimmune Diseases

    Alexander Schmitz;Ananthakrishnan Sankaranarayanan;Philippe Azam;Kristina Schmidt-Lassen

  • K+ Channel Expression during B Cell Differentiation: Implications for Immunomodulation and Autoimmunity

    Heike Wulff;Hans Günther Knaus;Michael Pennington;K. George Chandy

Frequent Co-Authors

K. George Chandy
K. George Chandy Nanyang Technological University
Lee-Way Jin
Lee-Way Jin University of California, Davis
Michael W. Pennington
Michael W. Pennington University of Florida
Michael D. Cahalan
Michael D. Cahalan University of California, Irvine
George A. Gutman
George A. Gutman University of California, Irvine
Pamela J. Lein
Pamela J. Lein University of California, Davis
Peter Bradding
Peter Bradding University of Leicester
Bruce D. Hammock
Bruce D. Hammock University of California, Davis
Cristina Limatola
Cristina Limatola Sapienza University of Rome
Vikram G. Shakkottai
Vikram G. Shakkottai The University of Texas Southwestern Medical Center

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