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Biology and Biochemistry

D-Index
77
Citations
35533
World Ranking
4678
National Ranking
16

Overview

K. George Chandy is affiliated with Nanyang Technological University in Singapore, conducting research predominantly in the fields of biochemistry, genetics, molecular biology, and medicine. Their work spans multiple subfields including molecular biology, cardiology and cardiovascular medicine, cellular and molecular neuroscience, sensory systems, and immunology. The main research topics covered by Chandy focus on ion channel regulation and function, nicotinic acetylcholine receptor studies, cardiac electrophysiology and arrhythmias, ion channels and receptors, neuroscience and neuropharmacology research, toxin mechanisms and immunotoxins, as well as neuroscience and neural engineering.

Chandy has published extensively, contributing notably to scientific journals and research aggregators. Frequent publication venues include:

  • IUPHAR/BPS Guide to Pharmacology CITE
  • Zenodo (CERN European Organization for Nuclear Research)
  • ACS Pharmacology & Translational Science
  • Channels
  • Nature Communications

Selected recent papers authored or coauthored by Chandy and colleagues are:

  • "Structure of the voltage-gated potassium channel K V 1.3: Insights into the inactivated conformation and binding to therapeutic leads," 2023, published in Channels
  • "Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin," 2020, ACS Pharmacology & Translational Science
  • "Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel," 2025, Nature Communications
  • "Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis," 2021, Frontiers in Pharmacology
  • "Voltage-gated potassium channels (Kv) in GtoPdb v.2023.1," 2023, IUPHAR/BPS Guide to Pharmacology CITE

Their research collaboration includes frequent coauthors such as Heike Wulff, Raymond S. Norton, Stephan Grissmer, George A. Gutman, and Karoline Sanches. Each of these collaborators has been involved with Chandy on multiple publications, indicating sustained joint research efforts.

Best Publications

  • International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

    W. A. Catterall;K. G. Chandy;D. E. Clapham;G. A. Gutman

  • International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels

    Aguan D. Wei;George A. Gutman;Richard W Aldrich;K. George Chandy

  • Voltage-gated K + channels in human T lymphocytes: a role in mitogenesis?

    Thomas E. DeCoursey;K. George Chandy;Sudhir Gupta;Michael D. Cahalan

  • Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: A potential immunosuppressant

    Heike Wulff;Mark J. Miller;Wolfram Hänsel;Stephan Grissmer

  • The functional network of ion channels in T lymphocytes

    Michael D. Cahalan;K. George Chandy

  • Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

    Christine Beeton;Heike Wulff;Nathan E. Standifer;Philippe Azam

  • International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels : potassium channels

    George A. Gutman;K. George Chandy;John P. Adelman;Jayashree Aiyar

  • K+ channels as targets for specific immunomodulation.

    K. George Chandy;Heike Wulff;Christine Beeton;Michael Pennington

  • The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS

    Heike Wulff;Peter A. Calabresi;Rameeza Allie;Sung Yun

  • The Concise Guide to PHARMACOLOGY 2017/18: Overview

    Stephen P. H. Alexander;Eamonn Kelly;Neil V. Marrion;John A. Peters

  • Up-regulation of the IKCa1 Potassium Channel during T-cell Activation MOLECULAR MECHANISM AND FUNCTIONAL CONSEQUENCES

    Sanjiv Ghanshani;Heike Wulff;Mark J. Miller;Heike Rohm

  • A voltage-gated potassium channel in human T lymphocytes.

    M D Cahalan;K G Chandy;T E DeCoursey;S Gupta

  • A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies.

    Jan Tytgat;K.George Chandy;Maria L Garcia;George A Gutman

  • Voltage-gated potassium channels are required for human T lymphocyte activation.

    K G Chandy;T E DeCoursey;M D Cahalan;C McLaughlin

  • Selective blockade of T lymphocyte K+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

    Christine Beeton;Heike Wulff;Jocelyne Barbaria;Olivier Clot-Faybesse

  • Calmodulin Mediates Calcium-dependent Activation of the Intermediate Conductance KCa Channel,IKCa1 *

    Christopher M. Fanger;Sanjiv Ghanshani;Naomi J. Logsdon;Heiko Rauer

  • ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide

    Katalin Kalman;Michael W. Pennington;Mark D. Lanigan;Angela Nguyen

  • Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins

    Jayashree Aiyar;Jane M. Withka;James P. Rizzi;David H. Singleton

  • Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases

    Christine Beeton;Michael W. Pennington;Heike Wulff;Satendra Singh

  • Molecular Properties and Physiological Roles of Ion Channels in the Immune System

    Michael D. Cahalan;Heike Wulff;K. George Chandy

Frequent Co-Authors

George A. Gutman
George A. Gutman University of California, Irvine
Heike Wulff
Heike Wulff University of California, Davis
Michael D. Cahalan
Michael D. Cahalan University of California, Irvine
Michael W. Pennington
Michael W. Pennington University of Florida
Peter A. Calabresi
Peter A. Calabresi Johns Hopkins University School of Medicine
Raymond S. Norton
Raymond S. Norton Monash University
Mark J. Miller
Mark J. Miller Washington University in St. Louis
Vikram G. Shakkottai
Vikram G. Shakkottai The University of Texas Southwestern Medical Center
Sudhir Gupta
Sudhir Gupta University of California, Irvine
Maria L. Garcia
Maria L. Garcia MSD (United States)

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