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Medicine

D-Index
95
Citations
27076
World Ranking
10198
National Ranking
5241

Overview

Lu Cai is affiliated with the University of Louisville in the United States and has a substantial body of research centered primarily in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work encompasses various subfields, including Molecular Biology, Health, Toxicology and Mutagenesis, Cardiology and Cardiovascular Medicine, Nutrition and Dietetics, and Pulmonary and Respiratory Medicine.

The scientist's research spans several important topics, with notable focus on Heavy Metal Exposure and Toxicity, Trace Elements in Health, Cardiovascular Function and Risk Factors, Pulmonary Hypertension Research and Treatments, Metabolism, Diabetes, and Cancer, Liver Disease Diagnosis and Treatment, and Adipose Tissue and Metabolism.

Lu Cai has co-authored numerous papers with frequent collaborators, including Yi Tan, Jamie L. Young, Kupper A. Wintergerst, Qian Lin, and Jiapeng Huang. These partnerships have contributed to a broad range of investigative studies in their fields of focus.

Key publication venues for Lu Cai include Research Square (6 publications), Toxicology and Applied Pharmacology (5 publications), Frontiers in Endocrinology (5 publications), Life Sciences (5 publications), and World Journal of Diabetes (5 publications). These journals highlight an emphasis on toxicology, endocrinology, and metabolic disease research.

Among recent scholarly papers, significant works include:

  • "Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence," 2020, Nature Reviews Cardiology
  • "Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways," 2021, Acta Pharmaceutica Sinica B
  • "Current understanding of hexavalent chromium [Cr(VI)] neurotoxicity and new perspectives," 2021, Environment International
  • "The gut microbiota and its interactions with cardiovascular disease," 2020, Microbial Biotechnology
  • "Diabetic-induced alterations in hepatic glucose and lipid metabolism: The role of type 1 and type 2 diabetes mellitus (Review)," 2020, Molecular Medicine Reports

Lu Cai has contributed to book publications with Frontiers Media and Oxford University Press. Titles include two volumes in the series Cardiovascular Diseases Related to Diabetes and Obesity released in 2022 and 2024, as well as The Hsu-Tang Library of Classical Chinese Literature: The Misadventures of Master Mugwort: A Joke Book Trilogy from Imperial China, published in 2023.

Best Publications

  • Hyperglycemia-Induced Apoptosis in Mouse Myocardium: Mitochondrial Cytochrome c–Mediated Caspase-3 Activation Pathway

    Lu Cai;Wei Li;Guangwu Wang;Luping Guo

  • Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

    Edward J. Calabrese;Kenneth A. Bachmann;A. John Bailer;P. Michael Bolger

  • miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

    Shan-shan Zhou;Jing-peng Jin;Ji-qun Wang;Ji-qun Wang;Zhi-guo Zhang;Zhi-guo Zhang

  • Oxidative stress and diabetic cardiomyopathy: a brief review.

    L Cai;Y J Kang;Y J Kang

  • Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

    Yi Tan;Zhiguo Zhang;Chao Zheng;Kupper A. Wintergerst

  • Attenuation by Metallothionein of Early Cardiac Cell Death via Suppression of Mitochondrial Oxidative Stress Results in a Prevention of Diabetic Cardiomyopathy

    Lu Cai;Lu Cai;Yuehui Wang;Guihua Zhou;Teresa Chen

  • Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

    Yi Tan;Tomonaga Ichikawa;Jinqing Li;Qiusheng Si

  • Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

    Xiaoqing He;Hong Kan;Lu Cai;Qiang Ma

  • Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

    Yang Bai;Wenpeng Cui;Wenpeng Cui;Ying Xin;Ying Xin;Xiao Miao;Xiao Miao

  • Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

    Xiang Wang;Xiang Wang;Xinxin Chen;Wenqian Zhou;Wenqian Zhou;Hongbo Men;Hongbo Men

  • Cardiac Metallothionein Induction Plays the Major Role in the Prevention of Diabetic Cardiomyopathy by Zinc Supplementation

    Jianxun Wang;Ye Song;Laila Elsherif;Zhenyuan Song

  • Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly chinese.

    Liang(孙亮) Sun;Oscar H. Franco;Frank B. Hu;Lu Cai

  • Cell death and diabetic cardiomyopathy.

    Lu Cai;Yujian Kang

  • Oxidative Stress, Diabetes, and Diabetic Complications

    Wei Wei;Qiuju Liu;Yi Tan;Lucheng Liu

  • Advanced Glycation End-Products Induce Connective Tissue Growth Factor-Mediated Renal Fibrosis Predominantly through Transforming Growth Factor β-Independent Pathway

    Guihua Zhou;Cai Li;Lu Cai;Lu Cai

  • Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy

    Lu Cai;Jianxun Wang;Yan Li;Xuihua Sun

  • The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: therapeutic effects by chelators.

    Yang Zheng;Xiao-Kun Li;Yuehui Wang;Lu Cai

  • Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy

    Pan Y;Wang Y;Zhao Y;Peng K

  • Diabetic Cardiomyopathy and Its Mechanisms: Role of Oxidative Stress and Damage

    Quan Liu;Shudong Wang;Shudong Wang;Lu Cai

  • Essentiality, Toxicology and Chelation Therapy of Zinc and Copper

    Lu Cai;Xiao-Kun Li;Ye Song;M. G Cherian

Frequent Co-Authors

Xiaokun Li
Xiaokun Li Wenzhou Medical University
Jian Xiao
Jian Xiao Wenzhou Medical University
Xiang Zhang
Xiang Zhang University of Louisville
Subrata Chakrabarti
Subrata Chakrabarti University of Western Ontario
Robert C.G. Martin
Robert C.G. Martin University of Louisville
Moosa Mohammadi
Moosa Mohammadi New York University Langone Medical Center
Jon B. Klein
Jon B. Klein University of Louisville
David W. Hein
David W. Hein University of Louisville
Craig J. McClain
Craig J. McClain University of Louisville
David M. Diamond
David M. Diamond University of South Florida

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