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Biology and Biochemistry

D-Index
69
Citations
17429
World Ranking
7369
National Ranking
3371

Overview

David W. Hein is affiliated with the University of Louisville in the United States. Their research encompasses significant contributions to the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broader fields, their work focuses on subfields such as Molecular Biology, Cancer Research, Spectroscopy, Oncology, and Pharmacology.

The main topics addressed in their research include:

  • Carcinogens and Genotoxicity Assessment
  • Epigenetics and DNA Methylation
  • Polyamine Metabolism and Applications
  • Genomics, phytochemicals, and oxidative stress
  • DNA Repair Mechanisms
  • Mass Spectrometry Techniques and Applications
  • Metabolomics and Mass Spectrometry Studies

David W. Hein has published extensively, with prominent contributions to several frequent publication venues. These include:

  • Archives of Toxicology
  • Frontiers in Pharmacology
  • Toxicology Letters
  • Scientific Reports
  • Toxicology Reports

Examples of recent papers associated with their research are:

  • "Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review" (2020, Expert Opinion on Drug Metabolism & Toxicology)
  • "CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism" (2020, Scientific Reports)
  • "Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1" (2021, Archives of Toxicology)
  • "Association between cigarette smoking and ovarian reserve among women seeking fertility care" (2022, PLoS ONE)
  • "Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes" (2020, Scientific Reports)

Frequent co-authors collaborating with David W. Hein include:

  • Mark A. Doll
  • Kyung U. Hong
  • Raúl A. Salazar-González
  • Mariam R. Habil
  • Kennedy M. Walls

Best Publications

  • Metabolic gene polymorphism frequencies in control populations.

    S. Garte;L. Gaspari;A.K. Alexandrie;C. Ambrosone

  • Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.

    David W. Hein;Mark A. Doll;Adrian J. Fretland;Matthew A. Leff

  • N-acetylation pharmacogenetics.

    W W Weber;D W Hein

  • NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.

    Montserrat García-Closas;Núria Malats;Debra Silverman;Mustafa Dosemeci

  • Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis.

    David W Hein

  • Nomenclature for N-acetyltransferases.

    K P Vatsis;W W Weber;D A Bell;J M Dupret

  • Acetylator genotype and arylamine-induced carcinogenesis.

    David W. Hein

  • Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases

    David W. Hein;Mark A. Doll;Timothy D. Rustan;Kevin Gray

  • Clinical Pharmacokinetics of Isoniazid

    Wendell W. Weber;David W. Hein

  • Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice.

    Stephen E McKim;Erwin Gäbele;Fuyumi Isayama;Jason C Lambert

  • N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk.

    David W. Hein

  • Etiologic heterogeneity among non-Hodgkin lymphoma subtypes

    Lindsay M. Morton;Sophia S. Wang;Wendy Cozen;Martha S. Linet

  • Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.

    Adrian J. Fretland;Matthew A. Leff;Mark A. Doll;David W. Hein

  • A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions

    Timothy P. Reilly;Lawrence H. Lash;Mark A. Doll;David W. Hein

  • Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

    Yuehui Wang;Wenke Feng;Wanli Xue;Yi Ling Tan

  • N-Acetyltransferase-2 genetic polymorphism, well-done meat intake, and breast cancer risk among postmenopausal women.

    Anne C. Deitz;Wei Zheng;Matthew A. Leff;Myron Gross

  • N-acetyltransferase 1 genetic polymorphism, cigarette smoking, well-done meat intake, and breast cancer risk.

    Wei Zheng;Anne C. Deitz;Deborah R. Campbell;Wan-Qing Wen

  • Metabolic activation of aromatic and heterocyclic N -hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases

    David W. Hein;Timothy D. Rustan;Ronald J. Ferguson;Mark A. Doll

  • Metallothionein Suppresses Angiotensin II-Induced Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation, Nitrosative Stress, Apoptosis, and Pathological Remodeling in the Diabetic Heart

    Guihua Zhou;Xiaokun Li;David W. Hein;Xilin Xiang

  • Metabolic Activation of N-Hydroxyarylamines and N-Hydroxyarylamides by 16 Recombinant Human NAT2 Allozymes: Effects of 7 Specific NAT2 Nucleic Acid Substitutions

    David W. Hein;Mark A. Doll;Timothy D. Rustan;Ronald J. Ferguson

Frequent Co-Authors

Nathaniel Rothman
Nathaniel Rothman National Institutes of Health
William M. Pierce
William M. Pierce University of Louisville
Robert C.G. Martin
Robert C.G. Martin University of Louisville
Wei Zheng
Wei Zheng Vanderbilt University Medical Center
James H. Woods
James H. Woods University of Michigan–Ann Arbor
Edith Sim
Edith Sim University of Oxford
Montserrat Garcia-Closas
Montserrat Garcia-Closas National Institutes of Health
Qing Lan
Qing Lan National Institutes of Health
Stephen J. Chanock
Stephen J. Chanock National Institutes of Health
Debra T. Silverman
Debra T. Silverman National Institutes of Health

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