2026 Dean J. Naisbitt: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	67	2700	2486	237	230	265	13211

Overview

Dean J. Naisbitt is affiliated with the University of Liverpool in the United Kingdom. Their research primarily focuses on medicine, with significant contributions across several subfields including pharmacology, immunology, oncology, pathology and forensic medicine, and rheumatology.

The core topics addressed in Naisbitt's work encompass drug-induced adverse reactions, asthma and respiratory diseases, urticaria and related conditions, drug-induced hepatotoxicity and protection, autoimmune bullous skin diseases, T-cell and B-cell immunology, and mast cells and histamine.

Naisbitt has published extensively, with a notable presence in frequent publication venues such as:

Chemical Research in Toxicology
Toxicological Sciences
Allergy
Clinical & Experimental Allergy
Journal of Cystic Fibrosis

Their recent papers include:

"T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses," 2021, Nature Communications
"HLA-B*13:01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients," 2021, Frontiers in Immunology
"Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity," 2021, Toxicological Sciences
"Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation," 2020, Toxicological Sciences
"Drug hapten-specific T-cell activation: Current status and unanswered questions," 2021, PROTEOMICS

Frequent co-authors in Naisbitt's collaborative research efforts include Xiaoli Meng, Munir Pirmohamed, Paul Thomson, Monday O. Ogese, and Sean Hammond.

Best Publications

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen

1158
Citations
Managing the challenge of chemically reactive metabolites in drug development

B. Kevin Park;Alan Boobis;Stephen Clarke;Chris E P Goldring

517
Citations
Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

Gary Middleton;Paul Silcocks;Trevor Cox;Juan Valle

447
Citations
Idiosyncratic Adverse Drug Reactions: Current Concepts

Jack Uetrecht;Dean J. Naisbitt

358
Citations
Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones.

D. J. Naisbitt;M. Britschgi;G. Wong;J. Farrell

297
Citations
Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

Manal M. Monshi;Lee Faulkner;Andrew Gibson;Rosalind E. Jenkins

276
Citations
Characterization of drug-specific T cells in lamotrigine hypersensitivity

Dean J. Naisbitt;John Farrell;Gavin Wong;Jan p.H. Depta

254
Citations
Recognition of Sulfamethoxazole and Its Reactive Metabolites by Drug-Specific CD4+ T Cells from Allergic Individuals

Benno Schnyder;Christoph Burkhart;Karin Schnyder-Frutig;Salome von Greyerz

245
Citations
Immune pathomechanism of drug hypersensitivity reactions

Werner J. Pichler;Dean J. Naisbitt;B. Kevin Park

231
Citations
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.

Richard J Weaver;Eric A Blomme;Amy E Chadwick;Ian M Copple

229
Citations
The danger hypothesis--potential role in idiosyncratic drug reactions.

Munir Pirmohamed;Dean J Naisbitt;Fraser Gordon;B.Kevin Park

213
Citations
Challenges and approaches for the development of safer immunomodulatory biologics

Jean G. Sathish;Swaminathan Sethu;Marie Christine Bielsky;Lolke De Haan

197
Citations
Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment.

Dean J. Naisbitt;Sfraser Gordon;Munir Pirmohamed;Bkevin Park

189
Citations
Cellular and Molecular Pathophysiology of Cutaneous Drug Reactions

Werner J. Pichler;Nikhil Yawalkar;Markus Britschgi;Jan Depta

171
Citations
Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine.

Dominic P. Williams;Munir Pirmohamed;Dean J. Naisbitt;Jack P. Uetrecht

169
Citations
Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo

Dean J Naisbitt;S Fraser Gordon;Munir Pirmohamed;Christoph Burkhart

165
Citations
Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity.

Dean J Naisbitt;Sally J Hough;Helen J Gill;Munir Pirmohamed

161
Citations
Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation.

Dean J. Naisbitt;John Farrell;S. Fraser Gordon;James L. Maggs

160
Citations
Activation of T cells by carbamazepine and carbamazepine metabolites.

Ying Wu;Joseph P. Sanderson;John Farrell;Nicola S. Drummond

160
Citations
Metabolic activation in drug allergies.

B.K. Park;D.J. Naisbitt;S.F. Gordon;N.R. Kitteringham

159
Citations
Stimulation of human T cells with sulfonamides and sulfonamide metabolites.

J. Luis Castrejon;Neil Berry;Sabah El-Ghaiesh;Basil Gerber

154
Citations
T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays.

Stefan F. Martin;Philipp R. Esser;Philipp R. Esser;Sonja Schmucker;Lisa Dietz

154
Citations

Frequent Co-Authors

B. Kevin Park University of Liverpool

Munir Pirmohamed University of Liverpool

Neil French University of Liverpool

Rosalind E. Jenkins University of Liverpool

James L. Maggs University of Liverpool

Werner J. Pichler University Hospital of Bern

Paul M. O'Neill University of Liverpool

Neil G. Berry University of Liverpool

Ann K. Daly Newcastle University

Ian Kimber University of Manchester

External Links

Personal website of Dean J. Naisbitt

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