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Chemistry

D-Index
50
Citations
7286
World Ranking
14577
National Ranking
814

Overview

James L. Maggs is affiliated with the University of Liverpool in the United Kingdom. Their research primarily focuses on medicine, with specific attention to several subfields including hepatology, surgery, pulmonary and respiratory medicine, pediatrics, perinatology and child health, as well as psychiatry and mental health.

The scientist's recent work includes studies addressing liver diseases and immunity, pediatric hepatobiliary diseases and treatments, gallbladder and bile duct disorders, pharmacological effects and toxicity studies, epilepsy research and treatment, and drug-induced hepatotoxicity and protection.

Key recent publications by James L. Maggs include the following:

  • Greater Transplant-Free Survival in Patients Receiving Obeticholic Acid for Primary Biliary Cholangitis in a Clinical Trial Setting Compared to Real-World External Controls, 2022, Gastroenterology
  • Evaluation of Clinical and Genetic Factors in the Population Pharmacokinetics of Carbamazepine, 2020, British Journal of Clinical Pharmacology

Frequent publication venues for their work are:

  • Gastroenterology
  • British Journal of Clinical Pharmacology

James L. Maggs has collaborated with multiple co-authors, including:

  • David Jones
  • George Mells
  • Carla Fiorella Murillo Perez
  • Holly Fisher
  • Shaun Hiu

Best Publications

  • THE ROLE OF METABOLIC ACTIVATION IN DRUG-INDUCED HEPATOTOXICITY

    B. Kevin Park;Neil R. Kitteringham;James L. Maggs;Munir Pirmohamed

  • Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

    Amy E. Mercer;James L. Maggs;Xiao-Ming Sun;Gerald M. Cohen

  • Acyl Glucuronides: The Good, The Bad and The Ugly

    Sophie L. Regan;James L. Maggs;Thomas G. Hammond;Craig Lambert

  • The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

    Amy E. Mercer;Ian M. Copple;James L. Maggs;Paul M. O'Neill

  • Isoquine and Related Amodiaquine Analogues: A New Generation of Improved 4-Aminoquinoline Antimalarials

    Paul M O'Neill;Amira Mukhtar;Paul A Stocks;Laura E Randle

  • Drug-protein conjugates--XIV. Mechanisms of formation of protein-arylating intermediates from amodiaquine, a myelotoxin and hepatotoxin in man

    J.L. Maggs;M.D. Tingle;N.R. Kitteringham;B.K. Park

  • GLUCURONIDATION OF DIHYDROARTEMISININ IN VIVO AND BY HUMAN LIVER MICROSOMES AND EXPRESSED UDP-GLUCURONOSYLTRANSFERASES

    Kenneth F. Ilett;Brian T. Ethell;James L. Maggs;Timothy M. E. Davis

  • Acyl Glucuronides: Biological Activity, Chemical Reactivity, and Chemical Synthesis

    Andrew V Stachulski;John R Harding;John C Lindon;James L Maggs

  • Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation.

    Dean J. Naisbitt;John Farrell;S. Fraser Gordon;James L. Maggs

  • Neutrophil Cytotoxicity of the Chemically Reactive Metabolite(s) of Clozapine: Possible Role in Agranulocytosis

    D P Williams;M Pirmohamed;D J Naisbitt;J L Maggs

  • Comparison of the Modulatory Effects of Human and Rat Liver Microsomal Metabolism on the Estrogenicity of Bisphenol A: Implications for Extrapolation to Humans

    R Elsby;J L Maggs;J Ashby;B K Park

  • The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.

    J L Maggs;D Williams;M Pirmohamed;B K Park

  • Metabolism of Lamotrigine to a Reactive Arene Oxide Intermediate

    J L Maggs;D J Naisbitt;J N Tettey;M Pirmohamed

  • Role of reactive metabolites in drug-induced hepatotoxicity.

    A. Srivastava;J. L. Maggs;D. J. Antoine;D. P. Williams

  • Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation.

    D M Gentile;E S Tomlinson;J L Maggs;B K Park

  • Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.

    Jane R. Kenny;James L. Maggs;Xiaoli Meng;Deborah Sinnott

  • Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinine in vivo

    J.N.A. Tettey;J.L. Maggs;W.G. Rapeport;M. Pirmohamed

  • Multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: implications for hapten formation.

    Hayley E. Callan;Rosalind E. Jenkins;James L. Maggs;Sidonie N. Lavergne

  • Comparison of the Metabolism and Toxicity of Dapsone in Rat, Mouse and Man

    M D Tingle;R Mahmud;J L Maggs;M Pirmohamed

  • Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine

    H. Jewell;J. L. Maggs;A. C. Harrison;P. M. O'neill

  • An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin.

    RJ Riley;JL Maggs;C. Lambert;NR Kitteringham

Frequent Co-Authors

B. Kevin Park
B. Kevin Park University of Liverpool
Paul M. O'Neill
Paul M. O'Neill University of Liverpool
Munir Pirmohamed
Munir Pirmohamed University of Liverpool
Dean J. Naisbitt
Dean J. Naisbitt University of Liverpool
Stephen A. Ward
Stephen A. Ward Liverpool School of Tropical Medicine
Rosalind E. Jenkins
Rosalind E. Jenkins University of Liverpool
David Back
David Back University of Liverpool
Ian D. Wilson
Ian D. Wilson Imperial College London
Philip C. Bulman Page
Philip C. Bulman Page University of East Anglia
Neil G. Berry
Neil G. Berry University of Liverpool

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