World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
66
Citations
17345
World Ranking
7214
National Ranking
2145

Overview

Amit S. Kalgutkar is affiliated with Pfizer in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Molecular Biology, Infectious Diseases, Pharmacology, Computational Theory and Mathematics, and Biochemistry.

The scientist has contributed extensively to topics such as Pharmacogenetics and Drug Metabolism, SARS-CoV-2 and COVID-19 Research, Computational Drug Discovery Methods, Liver Disease Diagnosis and Treatment, Drug Transport and Resistance Mechanisms, Water Treatment and Disinfection, and Pancreatic function and diabetes.

Frequent publication venues for Amit S. Kalgutkar include:

  • Journal of Medicinal Chemistry
  • Chemical Research in Toxicology
  • Drug Metabolism Reviews
  • Drug Metabolism and Disposition
  • bioRxiv (Cold Spring Harbor Laboratory)

Notable recent papers authored by or involving Amit S. Kalgutkar include:

  • "An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19," 2021, published in Science
  • "A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor," 2022, Journal of Medicinal Chemistry
  • "Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans," 2022, Drug Metabolism and Disposition
  • "Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product N-Nitrosamine Impurities," 2022, Chemical Research in Toxicology
  • "Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose," 2020, Journal of Medicinal Chemistry

The scientist has collaborated frequently with other researchers, including Heather Eng, R. Scott Obach, Britton Boras, Li Di, and Nandini C. Patel.

Best Publications

  • Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.

    Antonia F. Stepan;Daniel P. Walker;Daniel P. Walker;Jonathan Bauman;Jonathan Bauman;David A. Price;David A. Price

  • A comprehensive listing of bioactivation pathways of organic functional groups.

    Amit S. Kalgutkar;Iain Gardner;R. Scott Obach;Christopher L. Shaffer

  • Arachidonic Acid Oxygenation by COX-1 and COX-2 MECHANISMS OF CATALYSIS AND INHIBITION

    Lawrence J. Marnett;Scott W. Rowlinson;Douglas C. Goodwin;Amit S. Kalgutkar

  • Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.

    Amit S. Kalgutkar;Alan B. Marnett;Brenda C. Crews;Rory P. Remmel

  • A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385*

    Scott W. Rowlinson;James R. Kiefer;Jeffery J. Prusakiewicz;Jennifer L. Pawlitz

  • On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

    Tina R White;Chad M Renzelman;Arthur C Rand;Taha Rezai;Taha Rezai

  • Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2

    Amit S. Kalgutkar;Brenda C. Crews;Brenda C. Crews;Scott W. Rowlinson;Scott W. Rowlinson;Carlos Garner;Carlos Garner

  • Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.

    Amit S. Kalgutkar;Brenda C. Crews;Scott W. Rowlinson;Alan B. Marnett

  • Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions.

    Amit S. Kalgutkar;R. Scott Obach;Tristan S. Maurer

  • Cyclooxygenase 2 inhibitors: discovery, selectivity and the future.

    Lawrence J. Marnett;Amit S. Kalgutkar

  • Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.

    R. Scott Obach;Amit S. Kalgutkar;John R. Soglia;Sabrina X. Zhao

  • Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

    Wishka Dg;Walker Dp;Yates Km;Reitz Sc

  • Minimising the potential for metabolic activation in drug discovery.

    Amit S Kalgutkar;John R Soglia

  • Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors.

    Amit S. Kalgutkar;Deepak K. Dalvie;Neal Castagnoli;Timothy J. Taylor

  • Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.

    Emily C. Cokorinos;Jake Delmore;Allan R. Reyes;Bina Albuquerque

  • Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks

    Suvi T. M. Orr;Sharon L. Ripp;T. Eric Ballard;Jaclyn L. Henderson

  • Drug discovery for a new generation of covalent drugs

    Amit S Kalgutkar;Deepak K Dalvie

  • Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction.

    Jonathon N Bauman;Joan M Kelly;Sakambari Tripathy;Sabrina X Zhao

  • BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4

    Amit S. Kalgutkar;Alfin D. N. Vaz;Mary E. Lame;Kirk R. Henne

  • Covalent Modification of Cyclooxygenase-2 (COX-2) by 2-Acetoxyphenyl Alkyl Sulfides, a New Class of Selective COX-2 Inactivators†

    Kalgutkar As;Kozak Kr;Crews Bc;Hochgesang Gp

Frequent Co-Authors

Lawrence J. Marnett
Lawrence J. Marnett Vanderbilt University
R. Scott Obach
R. Scott Obach Pfizer (United States)
David Price
David Price University of Aberdeen
Spiros Liras
Spiros Liras University of California, San Francisco
Li Di
Li Di Pfizer (United States)
Jeffrey A. Pfefferkorn
Jeffrey A. Pfefferkorn Pfizer (United States)
Matthew P. Jacobson
Matthew P. Jacobson University of California, San Francisco
Neal Castagnoli
Neal Castagnoli Virginia Tech
Marc Foretz
Marc Foretz Université Paris Cité
Benoit Viollet
Benoit Viollet Institut Cochin

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students studying Chemistry in the USA, exploring related fields can open new career avenues. One such pathway is forensic science, which combines chemical analysis with criminal investigation techniques. Pursuing a forensic science degree online offers flexibility and the opportunity to develop practical skills applicable in labs, law enforcement, and research.

Beyond forensic science, specialized fields like forensic psychology also complement a chemistry background, especially for those interested in the behavioral aspects of criminal investigations. Quality forensic psychology master's programs online provide advanced training that can broaden your expertise and career prospects.

Career options in forensic science are diverse, ranging from crime lab analysts to forensic toxicologists. Understanding the various forensic science careers available can help students align their education with their professional goals.

Finally, it’s important to consider the financial investment involved. Learning how much it costs to get a criminal justice degree can provide valuable insight into budgeting for education related to these interdisciplinary fields.

Best Scientists Citing Amit S. Kalgutkar

Trending Scientists