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Amit S. Kalgutkar

D-Index & Metrics

Chemistry

D-Index
66
Citations
17345
World Ranking
7212
National Ranking
2144

Amit S. Kalgutkar publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Amit S. Kalgutkar sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 223 publications — 41st percentile

41% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Amit S. Kalgutkar D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Amit S. Kalgutkar sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 66 D-Index — 60th percentile

60% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Amit S. Kalgutkar is affiliated with Pfizer in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Molecular Biology, Infectious Diseases, Pharmacology, Computational Theory and Mathematics, and Biochemistry.

The scientist has contributed extensively to topics such as Pharmacogenetics and Drug Metabolism, SARS-CoV-2 and COVID-19 Research, Computational Drug Discovery Methods, Liver Disease Diagnosis and Treatment, Drug Transport and Resistance Mechanisms, Water Treatment and Disinfection, and Pancreatic function and diabetes.

Frequent publication venues for Amit S. Kalgutkar include:

  • Journal of Medicinal Chemistry
  • Chemical Research in Toxicology
  • Drug Metabolism Reviews
  • Drug Metabolism and Disposition
  • bioRxiv (Cold Spring Harbor Laboratory)

Notable recent papers authored by or involving Amit S. Kalgutkar include:

  • "An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19," 2021, published in Science
  • "A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor," 2022, Journal of Medicinal Chemistry
  • "Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans," 2022, Drug Metabolism and Disposition
  • "Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product N-Nitrosamine Impurities," 2022, Chemical Research in Toxicology
  • "Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose," 2020, Journal of Medicinal Chemistry

The scientist has collaborated frequently with other researchers, including Heather Eng, R. Scott Obach, Britton Boras, Li Di, and Nandini C. Patel.

Best Publications

  • Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.

    Antonia F. Stepan;Daniel P. Walker;Daniel P. Walker;Jonathan Bauman;Jonathan Bauman;David A. Price;David A. Price

  • A comprehensive listing of bioactivation pathways of organic functional groups.

    Amit S. Kalgutkar;Iain Gardner;R. Scott Obach;Christopher L. Shaffer

  • Arachidonic Acid Oxygenation by COX-1 and COX-2 MECHANISMS OF CATALYSIS AND INHIBITION

    Lawrence J. Marnett;Scott W. Rowlinson;Douglas C. Goodwin;Amit S. Kalgutkar

  • Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.

    Amit S. Kalgutkar;Alan B. Marnett;Brenda C. Crews;Rory P. Remmel

  • A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385*

    Scott W. Rowlinson;James R. Kiefer;Jeffery J. Prusakiewicz;Jennifer L. Pawlitz

  • On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

    Tina R White;Chad M Renzelman;Arthur C Rand;Taha Rezai;Taha Rezai

  • Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2

    Amit S. Kalgutkar;Brenda C. Crews;Brenda C. Crews;Scott W. Rowlinson;Scott W. Rowlinson;Carlos Garner;Carlos Garner

  • Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.

    Amit S. Kalgutkar;Brenda C. Crews;Scott W. Rowlinson;Alan B. Marnett

  • Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions.

    Amit S. Kalgutkar;R. Scott Obach;Tristan S. Maurer

  • Cyclooxygenase 2 inhibitors: discovery, selectivity and the future.

    Lawrence J. Marnett;Amit S. Kalgutkar

  • Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.

    R. Scott Obach;Amit S. Kalgutkar;John R. Soglia;Sabrina X. Zhao

  • Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

    Wishka Dg;Walker Dp;Yates Km;Reitz Sc

  • Minimising the potential for metabolic activation in drug discovery.

    Amit S Kalgutkar;John R Soglia

  • Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors.

    Amit S. Kalgutkar;Deepak K. Dalvie;Neal Castagnoli;Timothy J. Taylor

  • Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.

    Emily C. Cokorinos;Jake Delmore;Allan R. Reyes;Bina Albuquerque

  • Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks

    Suvi T. M. Orr;Sharon L. Ripp;T. Eric Ballard;Jaclyn L. Henderson

  • Drug discovery for a new generation of covalent drugs

    Amit S Kalgutkar;Deepak K Dalvie

  • Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction.

    Jonathon N Bauman;Joan M Kelly;Sakambari Tripathy;Sabrina X Zhao

  • BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4

    Amit S. Kalgutkar;Alfin D. N. Vaz;Mary E. Lame;Kirk R. Henne

  • Covalent Modification of Cyclooxygenase-2 (COX-2) by 2-Acetoxyphenyl Alkyl Sulfides, a New Class of Selective COX-2 Inactivators†

    Kalgutkar As;Kozak Kr;Crews Bc;Hochgesang Gp

Frequent Co-Authors

Lawrence J. Marnett
Lawrence J. Marnett Vanderbilt University
R. Scott Obach
R. Scott Obach Pfizer (United States)
David Price
David Price University of Aberdeen
Spiros Liras
Spiros Liras University of California, San Francisco
Li Di
Li Di Pfizer (United States)
Jeffrey A. Pfefferkorn
Jeffrey A. Pfefferkorn Pfizer (United States)
Matthew P. Jacobson
Matthew P. Jacobson University of California, San Francisco
Neal Castagnoli
Neal Castagnoli Virginia Tech
Marc Foretz
Marc Foretz Université Paris Cité
Benoit Viollet
Benoit Viollet Institut Cochin

External Links

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Best Scientists Citing Amit S. Kalgutkar

Lawrence J. Marnett

Lawrence J. Marnett

Vanderbilt University

Publications: 85

Benoit Viollet

Benoit Viollet

Institut Cochin

Publications: 30

R. Scott Obach

R. Scott Obach

Pfizer (United States)

Publications: 26

Marc Foretz

Marc Foretz

Université Paris Cité

Publications: 24

Guang-Bo Ge

Guang-Bo Ge

Shanghai University

Publications: 16

David J. Craik

David J. Craik

University of Queensland

Publications: 15

B. Kevin Park

B. Kevin Park

University of Liverpool

Publications: 15

Horst Kessler

Horst Kessler

Technical University of Munich

Publications: 14

Mark T. D. Cronin

Mark T. D. Cronin

Liverpool John Moores University

Publications: 14

Thomas A. Baillie

Thomas A. Baillie

University of Washington

Publications: 14

F. Peter Guengerich

F. Peter Guengerich

Vanderbilt University

Publications: 13

William L. Smith

William L. Smith

University of Michigan–Ann Arbor

Publications: 13

Laurence J. Miller

Laurence J. Miller

Mayo Clinic

Publications: 12

Bruce E. Kemp

Bruce E. Kemp

Australian Catholic University

Publications: 12

Hiroaki Suga

Hiroaki Suga

University of Tokyo

Publications: 12

David P. Fairlie

David P. Fairlie

University of Queensland

Publications: 12

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