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Chemistry

D-Index
45
Citations
8241
World Ranking
16359
National Ranking
4075

Overview

Spiros Liras is affiliated with the University of California, San Francisco in the United States. Their work spans multiple fields of study including Medicine, Biochemistry, Genetics and Molecular Biology, as well as Materials Science. Within these broader disciplines, Liras has contributed to subfields such as Materials Chemistry, Genetics, Cell Biology, Hematology, and Epidemiology.

The primary topics of research addressed by Liras include Hemoglobinopathies and Related Disorders, Hemoglobin Structure and Function, Iron Metabolism and Disorders, Liver Disease Diagnosis and Treatment, Drug Transport and Resistance Mechanisms, Peroxisome Proliferator-Activated Receptors, and Crystallization and Solubility Studies.

Recent publications by Spiros Liras are:

  • PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease, 2020, Journal of Medicinal Chemistry
  • Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting, 2020, Journal of Medicinal Chemistry
  • CCDC 1002286: Experimental Crystal Structure Determination, 2023, The Cambridge Structural Database

Liras frequently publishes in venues such as the Journal of Medicinal Chemistry and The Cambridge Structural Database.

Collaborations form an important part of Liras's research output. Frequent coauthors include Shawn Cabral, Robert L. Dow, Benjamin A. Thuma, David J. Edmonds, and David A. Griffith, each having coauthored multiple works with Liras.

Best Publications

  • The Future of Peptide‐based Drugs

    David J. Craik;David P. Fairlie;Spiros Liras;David Price

  • On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

    Tina R White;Chad M Renzelman;Arthur C Rand;Taha Rezai;Taha Rezai

  • Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia

    Patrick R. Verhoest;Douglas S. Chapin;Michael Corman;Kari Fonseca

  • Enantioselective Intramolecular Cyclopropanations of Allylic and Homoallylic Diazoacetates and Diazoacetamides Using Chiral Dirhodium(II) Carboxamide Catalysts

    Michael P. Doyle;Richard E. Austin;A. Scott Bailey;Michael P. Dwyer

  • Comparative α‐Helicity of Cyclic Pentapeptides in Water

    Aline D. de Araujo;Huy N. Hoang;W. Mei Kok;Frederik Diness;Frederik Diness

  • Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

    Conan K. Wang;Susan E. Northfield;Barbara Colless;Stephanie Chaousis

  • Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.

    Romain Rouet;Benjamin A. Thuma;Marc D. Roy;Nathanael G. Lintner

  • Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

    Jeffrey A. Pfefferkorn;Angel Guzman-Perez;John Litchfield;Robert Aiello

  • Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.

    Cameron R. Pye;William M. Hewitt;Joshua Schwochert;Terra D. Haddad

  • A Mild Method for the Preparation of 1,3,4-Oxadiazoles: Triflic Anhydride Promoted Cyclization of Diacylhydrazines

    Spiros Liras;Martin P. Allen;Barb E. Segelstein

  • Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

    Daniel S. Nielsen;Huy N. Hoang;Rink-Jan Lohman;Timothy A. Hill

  • Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products

    Andrew T. Bockus;Katrina W. Lexa;Cameron R. Pye;Amit S. Kalgutkar

  • Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors.

    Thomas A. Chappie;John M. Humphrey;Martin P. Allen;Kimberly G. Estep

  • Use of 3D properties to characterize beyond rule-of-5 property space for passive permeation.

    Cristiano R. W. Guimarães;Alan M. Mathiowetz;Marina Shalaeva;Gilles Goetz

  • Peptidic macrocyclization via palladium-catalyzed chemoselective indole C-2 arylation.

    Huijun Dong;Chris Limberakis;Spiros Liras;David Price

  • Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

    Arthur C. Rand;Siegfried S. F. Leung;Heather Eng;Charles J. Rotter

  • Fmoc-based Synthesis of Disulfide-Rich Cyclic Peptides

    Olivier Cheneval;Christina I. Schroeder;Thomas Durek;Phillip Walsh

  • Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

    Nathanael G. Lintner;Kim F. McClure;Donna Petersen;Allyn T. Londregan

  • ENANTIO- AND DIASTEREOSELECTIVITY IN THE INTRAMOLECULAR CYCLOPROPANATION OF SECONDARY ALLYLIC DIAZOACETATES

    Stephen F. Martin;Mark R. Spaller;Spiros Liras;Benoit Hartmann

  • Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor

    Carlos A. Sanhueza;Carlos A. Sanhueza;Michael M. Baksh;Michael M. Baksh;Benjamin Thuma;Marc D. Roy

  • Applications of Vinylogous Mannich Reactions. Total Syntheses of the Ergot Alkaloids Rugulovasines A and B and Setoclavine

    Spiros Liras;Christopher L. Lynch;Andrew M. Fryer;Binh T. Vu

Frequent Co-Authors

David Price
David Price University of Aberdeen
Stephen F. Martin
Stephen F. Martin The University of Texas at Austin
David J. Craik
David J. Craik University of Queensland
David P. Fairlie
David P. Fairlie University of Queensland
Amit S. Kalgutkar
Amit S. Kalgutkar Pfizer (United States)
Jamie H. D. Cate
Jamie H. D. Cate University of California, Berkeley
Matthew P. Jacobson
Matthew P. Jacobson University of California, San Francisco
Jeffrey A. Pfefferkorn
Jeffrey A. Pfefferkorn Pfizer (United States)
Michael P. Doyle
Michael P. Doyle The University of Texas at San Antonio
Jennifer A. Doudna
Jennifer A. Doudna University of California, Berkeley

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