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Jeffrey A. Pfefferkorn

Jeffrey A. Pfefferkorn

D-Index & Metrics

Chemistry

D-Index
41
Citations
6065
World Ranking
17776
National Ranking
4340

Overview

Jeffrey A. Pfefferkorn is affiliated with Pfizer in the United States and has contributed extensively to the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their research focuses on multiple aspects of liver disease, metabolism, and molecular mechanisms relevant to therapy and diagnosis.

The main topics of their work include:

  • Liver Disease Diagnosis and Treatment
  • Peroxisome Proliferator-Activated Receptors
  • Drug Transport and Resistance Mechanisms
  • Diet, Metabolism, and Disease
  • Diet and metabolism studies
  • Pancreatic function and diabetes
  • Hepatitis C virus research

Pfefferkorn has published research in several key scientific journals. Frequent publication venues for their work include:

  • Journal of Medicinal Chemistry
  • Nature Medicine
  • Cellular and Molecular Gastroenterology and Hepatology
  • Molecular Metabolism
  • Nature Metabolism

Recent papers authored or co-authored by Pfefferkorn encompass significant topics related to metabolic disorders and liver disease. These include:

  • ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials, 2021, Nature Medicine
  • Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems, 2020, Cellular and Molecular Gastroenterology and Hepatology
  • Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction, 2021, Molecular Metabolism
  • Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose, 2020, Journal of Medicinal Chemistry
  • De novo lipogenesis is essential for platelet production in humans, 2020, Nature Metabolism

The scientist frequently collaborates with other researchers in the field. Notable frequent co-authors include:

  • Trenton T. Ross
  • Collin Crowley
  • William P. Esler
  • Gregory J. Tesz
  • Matthew Dowling

Pfefferkorn's research covers a range of subfields such as Epidemiology, Molecular Biology, Oncology, Endocrinology, Diabetes and Metabolism, and Physiology. This diverse involvement reflects the interdisciplinary nature of their work spanning disease mechanisms, metabolic regulation, and therapeutic development.

Best Publications

  • Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase Synthesis of Benzopyrans

    K. C. Nicolaou;J. A. Pfefferkorn;A. J. Roecker;G.-Q. Cao

  • Natural Product-like Combinatorial Libraries Based on Privileged Structures. 2. Construction of a 10 000-Membered Benzopyran Library by Directed Split-and-Pool Chemistry Using NanoKans and Optical Encoding

    K. C. Nicolaou;J. A. Pfefferkorn;H. J. Mitchell;A. J. Roecker

  • Natural Product-like Combinatorial Libraries Based on Privileged Structures. 3. The “Libraries from Libraries” Principle for Diversity Enhancement of Benzopyran Libraries

    K. C. Nicolaou;J. A. Pfefferkorn;S. Barluenga;H. J. Mitchell

  • SOLID AND SOLUTION PHASE SYNTHESIS AND BIOLOGICAL EVALUATION OF COMBINATORIAL SARCODICTYIN LIBRARIES

    K. C. Nicolaou;Nicolas Charles Winssinger;D. Vourloumis;T. Ohshima

  • Selenium‐Based Solid‐Phase Synthesis of Benzopyrans I: Applications to Combinatorial Synthesis of Natural Products

    K. C. Nicolaou;Jeffrey A. Pfefferkorn;Guo-Qiang Cao

  • Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

    Jeffrey A. Pfefferkorn;Angel Guzman-Perez;John Litchfield;Robert Aiello

  • Total Synthesis of Eleutherobin

    K. C. Nicolaou;K. C. Nicolaou;Floris van Delft;Floris van Delft;Takashi Ohshima;Takashi Ohshima;Dionisios Vourloumis;Dionisios Vourloumis

  • A Novel Strategy for the Solid-Phase Synthesis of Substituted Indolines

    K. C. Nicolaou;A. J. Roecker;and Jeffrey A. Pfefferkorn;Gou-Qiang Cao

  • Total Synthesis of Eleutherobin and Eleuthosides A and B

    K. C. Nicolaou;T. Ohshima;S. Hosokawa;F. L. Van Delft

  • Selenium-Based Solid-Phase Synthesis of Benzopyrans II: Applications to Combinatorial Synthesis of Medicinally Relevant Small Organic Molecules.

    K. C. Nicolaou;Guo-Qiang Cao;Jeffrey A. Pfefferkorn

  • Glycomimetic ligands for the human asialoglycoprotein receptor.

    Sreeman K Mamidyala;Sanjay Dutta;Boris A Chrunyk;Cathy Préville

  • SYNTHESIS OF THE TRICYCLIC CORE OF ELEUTHEROBIN AND SARCODICTYINS AND TOTAL SYNTHESIS OF SARCODICTYIN A

    K. C. Nicolau;J. Y. Xu;S. Kim;T. Ohshima

  • Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.

    Jessica E. C. Jones;William P. Esler;Rushi Patel;Adhiraj Lanba

  • Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).

    K. C. Nicolaou;Robert Hughes;Jeffrey A. Pfefferkorn;Sofia Barluenga

  • Total Synthesis of Sarcodictyins A and B

    K. C. Nicolaou;J. Y. Xu;S. Kim;J. Pfefferkorn

  • Solution and Solid‐Phase Synthesis of Functionalized 3‐Arylbenzofurans by a Novel Cyclofragmentation – Release Pathway

    K. C. Nicolaou;Scott A. Snyder;Antony Bigot;Jeffrey A. Pfefferkorn

  • Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase

    KC Nicolaou;KC Nicolaou;JA Pfefferkorn;F Schuler;AJ Roecker

  • Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

    Kentaro Futatsugi;Daniel W. Kung;Suvi T. M. Orr;Shawn Cabral

  • Synthesis of the Fully Functionalized Bicyclic Core of Garsubellin A

    K. C. Nicolaou;J. A. Pfefferkorn;and S. Kim;H. X. Wei

  • Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid

    Jeffrey A. Pfefferkorn;Richard Nugent;Rebecca J. Gross;Meredith Greene

  • A facile method for the solution and solid-phase synthesis of substituted [3.3.1] bicycles.

    K. C. Nicolaou;Jeffrey A. Pfefferkorn;Guo-Qiang Cao;Sanghee Kim

  • Total synthesis of sarcodictyins A and B: Solid- and solution-phase synthesis and biological evaluation of combinatorial sarcodictyin libraries

    K. C. Nicolaou;N. Winssinger;D. Vourloumis;T. Ohshima

Frequent Co-Authors

K. C. Nicolaou
K. C. Nicolaou Rice University
Scott D. Larsen
Scott D. Larsen University of Michigan–Ann Arbor
Takashi Ohshima
Takashi Ohshima Kyushu University
Sanghee Kim
Sanghee Kim Seoul National University
Dionisios Vourloumis
Dionisios Vourloumis Demokritos National Centre for Scientific Research
Amit S. Kalgutkar
Amit S. Kalgutkar Pfizer (United States)
Nicolas Winssinger
Nicolas Winssinger University of Geneva
Spiros Liras
Spiros Liras University of California, San Francisco
Li Di
Li Di Pfizer (United States)
David Price
David Price University of Aberdeen

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