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Jeffrey A. Pfefferkorn

Jeffrey A. Pfefferkorn

Pfizer (United States)
United States

D-Index & Metrics

Chemistry

D-Index
41
Citations
6065
World Ranking
17774
National Ranking
4339

Jeffrey A. Pfefferkorn publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Jeffrey A. Pfefferkorn sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 101 publications — 2nd percentile

2% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Jeffrey A. Pfefferkorn D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Jeffrey A. Pfefferkorn sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 41 D-Index — 2nd percentile

2% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

Jeffrey A. Pfefferkorn is affiliated with Pfizer in the United States and has contributed extensively to the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their research focuses on multiple aspects of liver disease, metabolism, and molecular mechanisms relevant to therapy and diagnosis.

The main topics of their work include:

  • Liver Disease Diagnosis and Treatment
  • Peroxisome Proliferator-Activated Receptors
  • Drug Transport and Resistance Mechanisms
  • Diet, Metabolism, and Disease
  • Diet and metabolism studies
  • Pancreatic function and diabetes
  • Hepatitis C virus research

Pfefferkorn has published research in several key scientific journals. Frequent publication venues for their work include:

  • Journal of Medicinal Chemistry
  • Nature Medicine
  • Cellular and Molecular Gastroenterology and Hepatology
  • Molecular Metabolism
  • Nature Metabolism

Recent papers authored or co-authored by Pfefferkorn encompass significant topics related to metabolic disorders and liver disease. These include:

  • ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials, 2021, Nature Medicine
  • Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems, 2020, Cellular and Molecular Gastroenterology and Hepatology
  • Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction, 2021, Molecular Metabolism
  • Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose, 2020, Journal of Medicinal Chemistry
  • De novo lipogenesis is essential for platelet production in humans, 2020, Nature Metabolism

The scientist frequently collaborates with other researchers in the field. Notable frequent co-authors include:

  • Trenton T. Ross
  • Collin Crowley
  • William P. Esler
  • Gregory J. Tesz
  • Matthew Dowling

Pfefferkorn's research covers a range of subfields such as Epidemiology, Molecular Biology, Oncology, Endocrinology, Diabetes and Metabolism, and Physiology. This diverse involvement reflects the interdisciplinary nature of their work spanning disease mechanisms, metabolic regulation, and therapeutic development.

Best Publications

  • Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase Synthesis of Benzopyrans

    K. C. Nicolaou;J. A. Pfefferkorn;A. J. Roecker;G.-Q. Cao

  • Natural Product-like Combinatorial Libraries Based on Privileged Structures. 2. Construction of a 10 000-Membered Benzopyran Library by Directed Split-and-Pool Chemistry Using NanoKans and Optical Encoding

    K. C. Nicolaou;J. A. Pfefferkorn;H. J. Mitchell;A. J. Roecker

  • Natural Product-like Combinatorial Libraries Based on Privileged Structures. 3. The “Libraries from Libraries” Principle for Diversity Enhancement of Benzopyran Libraries

    K. C. Nicolaou;J. A. Pfefferkorn;S. Barluenga;H. J. Mitchell

  • SOLID AND SOLUTION PHASE SYNTHESIS AND BIOLOGICAL EVALUATION OF COMBINATORIAL SARCODICTYIN LIBRARIES

    K. C. Nicolaou;Nicolas Charles Winssinger;D. Vourloumis;T. Ohshima

  • Selenium‐Based Solid‐Phase Synthesis of Benzopyrans I: Applications to Combinatorial Synthesis of Natural Products

    K. C. Nicolaou;Jeffrey A. Pfefferkorn;Guo-Qiang Cao

  • Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

    Jeffrey A. Pfefferkorn;Angel Guzman-Perez;John Litchfield;Robert Aiello

  • Total Synthesis of Eleutherobin

    K. C. Nicolaou;K. C. Nicolaou;Floris van Delft;Floris van Delft;Takashi Ohshima;Takashi Ohshima;Dionisios Vourloumis;Dionisios Vourloumis

  • A Novel Strategy for the Solid-Phase Synthesis of Substituted Indolines

    K. C. Nicolaou;A. J. Roecker;and Jeffrey A. Pfefferkorn;Gou-Qiang Cao

  • Total Synthesis of Eleutherobin and Eleuthosides A and B

    K. C. Nicolaou;T. Ohshima;S. Hosokawa;F. L. Van Delft

  • Selenium-Based Solid-Phase Synthesis of Benzopyrans II: Applications to Combinatorial Synthesis of Medicinally Relevant Small Organic Molecules.

    K. C. Nicolaou;Guo-Qiang Cao;Jeffrey A. Pfefferkorn

  • Glycomimetic ligands for the human asialoglycoprotein receptor.

    Sreeman K Mamidyala;Sanjay Dutta;Boris A Chrunyk;Cathy Préville

  • SYNTHESIS OF THE TRICYCLIC CORE OF ELEUTHEROBIN AND SARCODICTYINS AND TOTAL SYNTHESIS OF SARCODICTYIN A

    K. C. Nicolau;J. Y. Xu;S. Kim;T. Ohshima

  • Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.

    Jessica E. C. Jones;William P. Esler;Rushi Patel;Adhiraj Lanba

  • Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).

    K. C. Nicolaou;Robert Hughes;Jeffrey A. Pfefferkorn;Sofia Barluenga

  • Total Synthesis of Sarcodictyins A and B

    K. C. Nicolaou;J. Y. Xu;S. Kim;J. Pfefferkorn

  • Solution and Solid‐Phase Synthesis of Functionalized 3‐Arylbenzofurans by a Novel Cyclofragmentation – Release Pathway

    K. C. Nicolaou;Scott A. Snyder;Antony Bigot;Jeffrey A. Pfefferkorn

  • Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase

    KC Nicolaou;KC Nicolaou;JA Pfefferkorn;F Schuler;AJ Roecker

  • Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

    Kentaro Futatsugi;Daniel W. Kung;Suvi T. M. Orr;Shawn Cabral

  • Synthesis of the Fully Functionalized Bicyclic Core of Garsubellin A

    K. C. Nicolaou;J. A. Pfefferkorn;and S. Kim;H. X. Wei

  • Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid

    Jeffrey A. Pfefferkorn;Richard Nugent;Rebecca J. Gross;Meredith Greene

  • A facile method for the solution and solid-phase synthesis of substituted [3.3.1] bicycles.

    K. C. Nicolaou;Jeffrey A. Pfefferkorn;Guo-Qiang Cao;Sanghee Kim

  • Total synthesis of sarcodictyins A and B: Solid- and solution-phase synthesis and biological evaluation of combinatorial sarcodictyin libraries

    K. C. Nicolaou;N. Winssinger;D. Vourloumis;T. Ohshima

Frequent Co-Authors

K. C. Nicolaou
K. C. Nicolaou Rice University
Scott D. Larsen
Scott D. Larsen University of Michigan–Ann Arbor
Takashi Ohshima
Takashi Ohshima Kyushu University
Sanghee Kim
Sanghee Kim Seoul National University
Dionisios Vourloumis
Dionisios Vourloumis Demokritos National Centre for Scientific Research
Amit S. Kalgutkar
Amit S. Kalgutkar Pfizer (United States)
Nicolas Winssinger
Nicolas Winssinger University of Geneva
Spiros Liras
Spiros Liras University of California, San Francisco
Li Di
Li Di Pfizer (United States)
David Price
David Price University of Aberdeen

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Best Scientists Citing Jeffrey A. Pfefferkorn

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Publications: 13

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Publications: 10

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Publications: 10

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Publications: 10

Ming-Wei Wang

Ming-Wei Wang

Chinese Academy of Sciences

Publications: 10

Cesare Gennari

Cesare Gennari

University of Milan

Publications: 10

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Publications: 9

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Dhevalapally B. Ramachary

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Publications: 9

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Publications: 9

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