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Chemistry

D-Index
43
Citations
5338
World Ranking
17357
National Ranking
4247

Overview

Scott D. Larsen is affiliated with the University of Michigan-Ann Arbor in the United States, with a research focus spanning multiple interconnected fields of study. Their contributions primarily relate to medicine and biochemistry, genetics, and molecular biology, with notable attention to molecular biology and pulmonary and respiratory medicine as leading subfields.

The scientist has published extensively on topics related to cancer, hypoxia, and metabolism; interstitial lung diseases including idiopathic pulmonary fibrosis; lung cancer treatments and mutations; occupational and environmental lung diseases; tuberculosis research and epidemiology; Pneumocystis jirovecii pneumonia detection and treatment; and receptor mechanisms and signaling.

Scott D. Larsen's recent publications include:

  • A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor (2020) in Molecular Pharmacology
  • Optimization of Eliglustat-Based Glucosylceramide Synthase Inhibitors as Substrate Reduction Therapy for Gaucher Disease Type 3 (2020) in ACS Chemical Neuroscience
  • Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy (2020) in European Journal of Medicinal Chemistry
  • Prevention of bleomycin-induced lung fibrosis via inhibition of the MRTF/SRF transcription pathway (2022) in Pharmacology Research & Perspectives
  • Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS (2020) in ACS Chemical Neuroscience

Frequent publication venues for Larsen's work include bioRxiv (Cold Spring Harbor Laboratory), ACS Chemical Neuroscience, Molecular Pharmacology, European Journal of Medicinal Chemistry, and Pharmacology Research & Perspectives.

The scientist has collaborated with several frequent co-authors, namely:

  • Michael W. Wilson (5 publications)
  • Bo Wen (3 publications)
  • Duxin Sun (3 publications)
  • Ronald J. Buckanovich (3 publications)
  • Richard R. Neubig (3 publications)

Larsen's research integrates diverse approaches within medicine and molecular biology to explore disease mechanisms and therapeutic strategies. Their contributions span from inhibitor development targeting specific biochemical pathways to investigations on lung diseases and infectious disease epidemiology.

Best Publications

  • Aza Diels-Alder reactions in aqueous solution: cyclocondensation of dienes with simple iminium salts generated under Mannich conditions

    Scott D. Larsen;Paul A. Grieco

  • X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

    Yahira M. Báez-Santos;Scott J. Barraza;Michael W. Wilson;Michael P. Agius

  • Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

    Laura A. Johnson;Eva S. Rodansky;Andrew J. Haak;Scott D. Larsen

  • Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence.

    Huiqing Zheng;Christopher J Colvin;Benjamin K Johnson;Paul D Kirchhoff

  • A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.

    Ilana Chefetz;Edward Grimley;Kun Yang;Linda Hong

  • Structure of methylguanidinium dihydrogenorthophosphate. A model compound for arginine-phosphate hydrogen bonding.

    F. A. Cotton;V. W. Day;E. E. Hazen;S. Larsen

  • Investigation of Potential Bioisosteric Replacements for the Carboxyl Groups of Peptidomimetic Inhibitors of Protein Tyrosine Phosphatase 1B: Identification of a Tetrazole-Containing Inhibitor with Cellular Activity

    Charlotta Liljebris;Scott D. Larsen;Derek Ogg;Barbara J. Palazuk

  • Targeting the myofibroblast genetic switch: Inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury

    Andrew J. Haak;Pei Suen Tsou;Mohammad A. Amin;Jeffrey H. Ruth

  • Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.

    J.E Bleasdale;D Ogg;B.J Palazuk;C.S Jacob

  • Reactions of Allylsilanes with Simple Iminium Salts in Water: A Facile Route to Piperidines via an Aminomethano Desilylation-Cyclization Process.

    S. D. Larsen;P. A. Grieco;W. F. Fobare

  • Reactions of allylsilanes with simple iminium salts in water: a facile route to piperidines via an aminomethano desilylation-cyclization process

    Scott D. Larsen;Paul A. Grieco;William F. Fobare

  • Heterocycle carboxamides as antiviral agents

    Gordon L. Bundy;Fred L. Ciske;Michael J. Genin;Steven E. Heasley

  • Nonstabilized imidate ylides by the desilylation method: a route to the pyrrolizidine alkaloids retronecine and indicine

    Edwin Vedejs;Scott Larsen;Frederick G. West

  • Synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent.

    S D Larsen;M A Connell;M M Cudahy;B R Evans

  • Aza Diels-Alder reactions in water: Cyclocondensation of C-acyl iminium ions with cyclopentadiene

    Paul A. Grieco;Scott D. Larsen;William F. Fobare

  • Synthesis and Biological Activity of a Novel Class of Small Molecular Weight Peptidomimetic Competitive Inhibitors of Protein Tyrosine Phosphatase 1B

    Scott D. Larsen;Tjeerd Barf;Charlotta Liljebris;Paul D. May

  • Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.

    Jessica L. Bell;Andrew J. Haak;Susan M. Wade;Paul D. Kirchhoff

  • Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer's disease.

    Michael W. Beck;Jeffrey S. Derrick;Richard A. Kerr;Shin Bi Oh

  • Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.

    Jeffrey A. Pfefferkorn;Yuntao Song;Kuai Lin Sun;Steven R. Miller

  • Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423.

    Chris R. Evelyn;Jessica L. Bell;Jenny G. Ryu;Susan M. Wade

  • Thermodynamic and Structure Guided Design of Statin Based Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase

    Ronald W. Sarver;Elizabeth Bills;Gary Bolton;Larry D. Bratton

  • Structure of bis(methylguanidinium) monohydrogen orthophosphate. A model for the arginine-phosphate interactions at the active site of staphylococcal nuclease and other phosphohydrolytic enzymes.

    F. A. Cotton;V. W. Day;E. E. Hazen;S. Larsen

  • Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis

    Cynthia Yu-Wai-Man;Cynthia Yu-Wai-Man;Bradley Spencer-Dene;Richard M. H. Lee;Kim Hutchings

Frequent Co-Authors

Richard R. Neubig
Richard R. Neubig Michigan State University
John J. G. Tesmer
John J. G. Tesmer Purdue University West Lafayette
Jeffrey A. Pfefferkorn
Jeffrey A. Pfefferkorn Pfizer (United States)
Duxin Sun
Duxin Sun University of Michigan–Ann Arbor
Richard F. Keep
Richard F. Keep University of Michigan–Ann Arbor
Thomas D. Hurley
Thomas D. Hurley Indiana University
David A. Fox
David A. Fox University of Michigan–Ann Arbor
Victor W. Day
Victor W. Day University of Kansas
Joseph Y. Cheung
Joseph Y. Cheung Temple University
James A. Shayman
James A. Shayman University of Michigan–Ann Arbor

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