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Best Scientists
2025
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Biology and Biochemistry
USA
2026

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Best Scientists

D-Index
167
Citations
119194
World Ranking
970
National Ranking
576

Biology and Biochemistry

D-Index
170
Citations
124239
World Ranking
90
National Ranking
68

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award

Overview

Randal J. Kaufman is affiliated with the Sanford Burnham Prebys Medical Discovery Institute in the United States. Their research primarily concentrates on areas within biochemistry, genetics, and molecular biology, with a significant portion of work also classified under medicine. The scientist's contributions span numerous subfields including cell biology, molecular biology, surgery, genetics, and epidemiology.

The research topics Kaufman focuses on include:

  • Endoplasmic Reticulum Stress and Disease
  • Pancreatic function and diabetes
  • Diabetes and associated disorders
  • RNA regulation and disease
  • Hemophilia Treatment and Research
  • Autophagy in Disease and Therapy
  • Heat shock proteins research

Kaufman has authored papers that have appeared in prominent publication venues. Frequent venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Gastroenterology
  • Diabetes
  • Molecular Therapy
  • Journal of Clinical Investigation

Some notable recent papers with publication year and venue are:

  • Mechanisms, regulation and functions of the unfolded protein response, 2020, Nature Reviews Molecular Cell Biology
  • Endoplasmic reticulum stress in liver diseases, 2022, Hepatology
  • ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis, 2023, Journal of Hepatology
  • Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus, 2021, Nature Reviews Endocrinology
  • IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis, 2020, Gastroenterology

Kaufman has collaborated frequently with a group of coauthors who contribute repeatedly to their publications. Frequent coauthors include:

  • Jing Yong
  • Peter Arvan
  • Cynthia Lebeaupin
  • Zhouji Chen
  • Pamela Itkin-Ansari

Best Publications

  • THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

    Martin Schröder;Randal J Kaufman

  • Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

    Randal J. Kaufman

  • From endoplasmic-reticulum stress to the inflammatory response

    Kezhong Zhang;Randal J. Kaufman

  • ER stress and the unfolded protein response.

    Martin Schröder;Randal J. Kaufman

  • Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?

    Jyoti D. Malhotra;Randal J. Kaufman

  • Orchestrating the unfolded protein response in health and disease

    Randal J. Kaufman

  • Mechanisms, regulation and functions of the unfolded protein response.

    Claudio Hetz;Kezhong Zhang;Randal J. Kaufman

  • A trip to the ER: coping with stress.

    D.Thomas Rutkowski;Randal J. Kaufman

  • A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

    Michael Boyce;Kevin F. Bryant;Céline Jousse;Kai Long

  • Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

    Nancy Kedersha;Georg Stoecklin;Maranatha Ayodele;Patrick Yacono

  • Protein misfolding in the endoplasmic reticulum as a conduit to human disease

    Miao Wang;Randal J. Kaufman

  • ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

    Jaeseok Han;Sung Hoon Back;Junguk Hur;Yu Hsuan Lin

  • Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

    Donalyn Scheuner;Benbo Song;Edward McEwen;Chuan Liu

  • Isolation and characterization of genomic and cDNA clones of human erythropoietin

    Kenneth Jacobs;Charles Shoemaker;Richard Rudersdorf;Suzanne D. Neill

  • Endoplasmic reticulum stress in liver disease

    Harmeet Malhi;Randal J. Kaufman

  • Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins

    Gordon G. Wong;JoAnn S. Witek;Patricia A. Temple;Kathleen M. Wilkens

  • Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival.

    Sara B. Cullinan;Donna Zhang;Mark Hannink;Edward Arvisais

  • Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

    Stewart Siyan Cao;Randal J. Kaufman

  • The endoplasmic reticulum and the unfolded protein response.

    Jyoti D. Malhotra;Randal J. Kaufman

  • A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

    Witoon Tirasophon;Ajith A. Welihinda;Randal J. Kaufman

Frequent Co-Authors

Debra D. Pittman
Debra D. Pittman Pfizer (United States)
Kezhong Zhang
Kezhong Zhang Wayne State University
David Ginsburg
David Ginsburg University of Michigan–Ann Arbor
Alnawaz Rehemtulla
Alnawaz Rehemtulla University of Michigan–Ann Arbor
David Ron
David Ron University of Cambridge
Antonis E. Koromilas
Antonis E. Koromilas McGill University
Maria Hatzoglou
Maria Hatzoglou Case Western Reserve University
Heather P. Harding
Heather P. Harding University of Cambridge
Kazutoshi Mori
Kazutoshi Mori Kyoto University
John M. Wozney
John M. Wozney Pfizer (Canada)

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