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Molecular Biology

D-Index
60
Citations
12339
World Ranking
1968
National Ranking
980

Overview

Maria Hatzoglou is affiliated with Case Western Reserve University in the United States. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology, Cell Biology, Physiology, Immunology, and Cancer Research. Their scientific work is distributed across several specialized topics including Endoplasmic Reticulum Stress and Disease, RNA modifications and cancer, RNA and protein synthesis mechanisms, RNA Research and Splicing, RNA regulation and disease, Mitochondrial Function and Pathology, and Adipose Tissue and Metabolism.

Maria Hatzoglou has contributed a substantial number of publications in various academic venues. The most frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory) with nine publications, Nature Communications with four, Cell Reports with three, Science Advances with one, and FEBS Journal with one publication. This diverse dissemination reflects a broad engagement with the scientific community focused on molecular and cellular biology.

Recent papers authored or co-authored by Maria Hatzoglou include the following:

  • Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR, 2021, Science Advances
  • Translational control of breast cancer plasticity, 2020, Nature Communications
  • Adaptation to chronic ER stress enforces pancreatic β-cell plasticity, 2022, Nature Communications
  • The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer, 2021, Nature Communications
  • A tale of two proteins: PACT and PKR and their roles in inflammation, 2021, FEBS Journal

Frequent collaborators in Maria Hatzoglou's research include Bo-Jhih Guan, Zhaofeng Gao, Ivan Topisirović, Raul Jobava, and Chien-Wen Chen. These collaborations often involve multiple projects and appear to have contributed significantly to their body of work.

The main scientific topics covered encompass:

  • Endoplasmic Reticulum Stress and Disease
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • RNA regulation and disease
  • Mitochondrial Function and Pathology
  • Adipose Tissue and Metabolism

Maria Hatzoglou's research thus consistently engages with complex biological stress responses and molecular pathways relevant to cancer, cellular plasticity, and metabolism, emphasizing RNA biology and mitochondrial function within these contexts.

Best Publications

  • ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

    Jaeseok Han;Sung Hoon Back;Junguk Hur;Yu Hsuan Lin

  • Cellular IRES-mediated translation: the war of ITAFs in pathophysiological states.

    Anton A Komar;Maria Hatzoglou

  • Internal ribosome entry sites in cellular mRNAs: Mystery of their existence

    Anton A. Komar;Maria Hatzoglou

  • Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β

    Li Ke Qu;Shirley Huang;Dionissios Baltzis;Ana Maria Rivas-Estilla

  • A stress-responsive RNA switch regulates VEGFA expression.

    Partho Sarothi Ray;Jie Jia;Peng Yao;Mithu Majumder

  • Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

    Mridusmita Saikia;Raul Jobava;Marc Parisien;Andrea Putnam

  • Regulation of Internal Ribosomal Entry Site-mediated Translation by Phosphorylation of the Translation Initiation Factor eIF2α

    James M. Fernandez;Ibrahim Yaman;Peter Sarnow;Martin D. Snider

  • The Zipper Model of Translational Control: A Small Upstream ORF Is the Switch that Controls Structural Remodeling of an mRNA Leader

    Ibrahim Yaman;James Fernandez;Haiyan Liu;Mark Caprara

  • Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

    Yujun Hao;Yardena Samuels;Qingling Li;Dawid Krokowski

  • Regulation of cationic amino acid transport: the story of the CAT-1 transporter.

    Maria Hatzoglou;James Fernandez;Ibrahim Yaman;Ellen Closs

  • Genome-wide Identification and Quantitative Analysis of Cleaved tRNA Fragments Induced by Cellular Stress

    Mridusmita Saikia;Dawid Krokowski;Bo Jhih Guan;Pavel Ivanov

  • Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation

    Alex J. Bott;I-Chen Peng;I-Chen Peng;Yongjun Fan;Brandon Faubert

  • Internal ribosome entry site-mediated translation of a mammalian mRNA is regulated by amino acid availability.

    James Fernandez;Ibrahim Yaman;Rangnath Mishra;William C. Merrick

  • Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response.

    Xing Huang Gao;Dawid Krokowski;Bo Jhih Guan;Ilya Bederman

  • DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer

    Callie R. Merry;Megan E. Forrest;Jessica N. Sabers;Lydia Beard

  • A Unique ISR Program Determines Cellular Responses to Chronic Stress

    Bo-Jhih Guan;Vincent van Hoef;Raul Jobava;Orna Elroy-Stein

  • Nutritional Control of mRNA Stability Is Mediated by a Conserved AU-rich Element That Binds the Cytoplasmic Shuttling Protein HuR

    Ibrahim Yaman;James Fernandez;Bedabrata Sarkar;Robert J. Schneider

  • Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.

    Bo Jhih Guan;Dawid Krokowski;Mithu Majumder;Christine L. Schmotzer

  • Hepatic gene transfer in animals using retroviruses containing the promoter from the gene for phosphoenolpyruvate carboxykinase.

    Maria Hatzoglou;Wouter Lamers;Fatima Bosch;Anthony Wynshaw-Boris

  • Expression of the neomycin-resistance (neo) gene induces alterations in gene expression and metabolism.

    Alfons Valera;Jose Carlos Perales;Jose Carlos Perales;Maria Hatzoglou;Fatima Bosch

Frequent Co-Authors

Antonis E. Koromilas
Antonis E. Koromilas McGill University
Anton A. Komar
Anton A. Komar Cleveland State University
William C. Merrick
William C. Merrick Case Western Reserve University
Randal J. Kaufman
Randal J. Kaufman Sanford Burnham Prebys Medical Discovery Institute
Richard W. Hanson
Richard W. Hanson Case Western Reserve University
Ivan Topisirovic
Ivan Topisirovic McGill University
Anthony Wynshaw-Boris
Anthony Wynshaw-Boris Case Western Reserve University
Belinda Willard
Belinda Willard Cleveland Clinic
Fatima Bosch
Fatima Bosch Autonomous University of Barcelona
David Danielpour
David Danielpour Case Western Reserve University

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