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Molecular Biology

D-Index
79
Citations
19393
World Ranking
1050
National Ranking
84

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Anne E. Willis is a researcher affiliated with the University of Cambridge in the United Kingdom. Their work spans several fields within biochemistry, genetics, molecular biology, and medicine, focusing on molecular and cellular mechanisms related to RNA and protein synthesis, cancer, and respiratory diseases.

Their recent publications include studies on ribosomal frameshifting and translation control with the following notable papers:

  • "N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting," 2023, Nature
  • "Control of translation elongation in health and disease," 2020, Disease Models & Mechanisms
  • "ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging," 2023, Science
  • "MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression," 2020, Cancer Discovery
  • "Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress," 2022, Molecular Cell

The frequent co-authors collaborating with Anne E. Willis include:

  • Marion MacFarlane
  • Robert F. Harvey
  • Mark Stoneley
  • C. Mark Smales
  • Owen J. Sansom

Research venues where Willis regularly publishes their work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Nucleic Acids Research
  • Scientific Reports
  • Biochemical Journal

Their primary fields of study consist of biochemistry, genetics, and molecular biology with a significant portion of research also situated in medicine. Subfields of study related to their work include:

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Immunology
  • Biotechnology
  • Oncology

Main research topics covered by Anne E. Willis are:

  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Occupational and environmental lung diseases
  • Cancer Research and Treatments
  • CRISPR and Genetic Engineering
  • PI3K/AKT/mTOR signaling in cancer

Anne E. Willis has been recognized as a Member of the European Molecular Biology Organization (EMBO), reflecting their involvement in the molecular biology research community.

Best Publications

  • Translational Regulation of Gene Expression during Conditions of Cell Stress

    Keith A. Spriggs;Martin Bushell;Anne E. Willis

  • Sustained translational repression by eIF2α-P mediates prion neurodegeneration

    Julie A. Moreno;Helois Radford;Diego Peretti;Joern R. Steinert

  • Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

    Julie A. Moreno;Mark Halliday;Colin Molloy;Helois Radford

  • Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression.

    Mark Stoneley;Anne E Willis

  • C-Myc 5′ untranslated region contains an internal ribosome entry segment

    Stoneley M;Paulin Fe;Le Quesne Jp;Chappell Sa

  • The implications of structured 5′ untranslated regions on translation and disease

    Becky M Pickering;Anne E Willis

  • Multiple display of foreign peptides on a filamentous bacteriophage: Peptides from Plasmodium falciparum circumsporozoite protein as antigens

    Judith Greenwood;Anne E. Willis;Richard N. Perham

  • Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein

    Kirsty Sawicka;Martin Bushell;Keith A. Spriggs;Anne E. Willis

  • Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation.

    H. A. Meijer;Y. W. Kong;W. T. Lu;A. Wilczynska

  • Re-programming of translation following cell stress allows IRES-mediated translation to predominate

    Keith A. Spriggs;Mark Stoneley;Martin Bushell;Anne E. Willis

  • The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.

    Sally A. Mitchell;Keith A. Spriggs;Mark J. Coldwell;Richard J. Jackson

  • mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

    William J. Faller;Thomas J. Jackson;John R. P. Knight;Rachel A. Ridgway

  • Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo.

    Joanne R Evans;Sally A Mitchell;Keith A Spriggs;Jerzy Ostrowski

  • c-Myc Protein Synthesis Is Initiated from the Internal Ribosome Entry Segment during Apoptosis

    Mark Stoneley;Stephen A. Chappell;Catherine L. Jopling;Martin Dickens

  • Comprehensive identification of RNA-protein interactions in any organism using orthogonal organic phase separation (OOPS).

    Rayner M.L. Queiroz;Tom Smith;Eneko Villanueva;Maria Marti-Solano

  • Initiation of Apaf-1 translation by internal ribosome entry

    Mark J Coldwell;Sally A Mitchell;Mark Stoneley;Marion MacFarlane

  • Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment

    Mark Stoneley;Tatyana Subkhankulova;John P. C. Le Quesne;Mark J. Coldwell

  • Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway.

    Michelle J West;Mark Stoneley;Anne E Willis

  • The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene

    Yi Wen Kong;Ian G. Cannell;Cornelia H. de Moor;Kirsti Hill

  • A perspective on mammalian upstream open reading frame function.

    Joanna Somers;Tuija Pöyry;Anne E. Willis

Frequent Co-Authors

Martin Bushell
Martin Bushell University of Glasgow
Marion MacFarlane
Marion MacFarlane University of Cambridge
David Dinsdale
David Dinsdale University of Leicester
Carolyn J.P. Jones
Carolyn J.P. Jones University of Manchester
Gerry Melino
Gerry Melino University of Rome Tor Vergata
Graham Packham
Graham Packham University of Southampton
David A. Barrett
David A. Barrett University of Nottingham
Kathryn S. Lilley
Kathryn S. Lilley University of Cambridge
Owen J. Sansom
Owen J. Sansom University of Glasgow
Richard A. Knight
Richard A. Knight University College London

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