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Molecular Biology

D-Index
61
Citations
13687
World Ranking
1907
National Ranking
154

Overview

Martin Bushell is affiliated with the University of Glasgow in the United Kingdom. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with a strong emphasis on Molecular Biology as a subfield. Additional areas of study include Cancer Research, Pulmonary and Respiratory Medicine, Cell Biology, and Epidemiology.

Their work spans several key topics in molecular and cellular research such as RNA Research and Splicing, RNA and protein synthesis mechanisms, RNA modifications and cancer, DNA Repair Mechanisms, PI3K/AKT/mTOR signaling in cancer, CRISPR and Genetic Engineering, and MicroRNA in disease regulation.

Martin Bushell has contributed to a number of research papers published in high-impact journals. Selected recent publications include:

  • The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer, 2021, Nature Genetics
  • Chromatin compartmentalization regulates the response to DNA damage, 2023, Nature
  • The roles of RNA in DNA double-strand break repair, 2020, British Journal of Cancer
  • MNK Inhibition Sensitizes KRAS -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression, 2020, Cancer Discovery
  • DNA:RNA hybrids form at DNA double-strand breaks in transcriptionally active loci, 2020, Cell Death and Disease

Frequent collaborators with Martin Bushell include Joseph A. Waldron, Owen J. Sansom, Aldo S. Bader, Ania Wilczynska, and Anne E. Willis. The scientist has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nucleic Acids Research, Nature Communications, Nature, and eLife.

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • Nature Communications
  • Nature
  • eLife

Martin Bushell's contributions encompass techniques and mechanisms fundamental to understanding RNA biology and cancer progression, including RNA splicing, synthesis, and modifications, as well as DNA repair pathways and signaling related to cancer biology.

Best Publications

  • microRNAs in cancer management.

    Yi W Kong;David Ferland-McCollough;Thomas J Jackson;Thomas J Jackson;Martin Bushell

  • Translational Regulation of Gene Expression during Conditions of Cell Stress

    Keith A. Spriggs;Martin Bushell;Anne E. Willis

  • Sustained translational repression by eIF2α-P mediates prion neurodegeneration

    Julie A. Moreno;Helois Radford;Diego Peretti;Joern R. Steinert

  • The complexity of miRNA-mediated repression.

    A Wilczynska;M Bushell

  • How do microRNAs regulate gene expression

    Ian G. Cannell;Yi Wen Kong;Martin Bushell

  • Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein

    Kirsty Sawicka;Martin Bushell;Keith A. Spriggs;Anne E. Willis

  • Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation.

    H. A. Meijer;Y. W. Kong;W. T. Lu;A. Wilczynska

  • Re-programming of translation following cell stress allows IRES-mediated translation to predominate

    Keith A. Spriggs;Mark Stoneley;Martin Bushell;Anne E. Willis

  • Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells

    M J Clemens;M Bushell;I W Jeffrey;V M Pain

  • mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

    William J. Faller;Thomas J. Jackson;John R. P. Knight;Rachel A. Ridgway

  • Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.

    Mark Halliday;Helois Radford;Karlijn A. M. Zents;Collin Molloy

  • Hijacking the translation apparatus by RNA viruses.

    Martin Bushell;Peter Sarnow

  • The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene

    Yi Wen Kong;Ian G. Cannell;Cornelia H. de Moor;Kirsti Hill

  • Internal ribosome entry segment-mediated translation during apoptosis: the role of IRES-trans-acting factors.

    K A Spriggs;M Bushell;S A Mitchell;A E Willis

  • Regulation of miRNA strand selection: follow the leader?

    Hedda A. Meijer;Ewan M. Smith;Martin Bushell

  • Polypyrimidine Tract Binding Protein Regulates IRES-Mediated Gene Expression during Apoptosis

    Martin Bushell;Mark Stoneley;Yi Wen Kong;Tiffany L. Hamilton

  • p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

    Ian G. Cannell;Yi W. Kong;Samantha J. Johnston;Melissa L. Chen

  • Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair.

    Wei-Ting Lu;Ben R. Hawley;George L. Skalka;Robert A. Baldock;Robert A. Baldock

  • Degradation of eukaryotic polypeptide chain initiation factor (eIF) 4G in response to induction of apoptosis in human lymphoma cell lines

    Michael J Clemens;Martin Bushell;Simon J Morley

  • Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes

    Ian R. Powley;Alexander Kondrashov;Lucy A. Young;Helen C. Dobbyn

Frequent Co-Authors

Anne E. Willis
Anne E. Willis University of Cambridge
Simon J. Morley
Simon J. Morley University of Sussex
Michael J. Clemens
Michael J. Clemens University of Sussex
Susan E. Ozanne
Susan E. Ozanne University of Cambridge
Marion MacFarlane
Marion MacFarlane University of Cambridge
David Dinsdale
David Dinsdale University of Leicester
Owen J. Sansom
Owen J. Sansom University of Glasgow
Nahum Sonenberg
Nahum Sonenberg McGill University
Kenneth Siddle
Kenneth Siddle University of Cambridge
Peter Sarnow
Peter Sarnow Stanford University

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