Kenneth Siddle

Overview

Best Publications

• PHOSPHOINOSITIDE 3-KINASE : THE KEY SWITCH MECHANISM IN INSULIN SIGNALLING

  Peter R. Shepherd;Dominic J. Withers;Kenneth Siddle

  1244
  Citations

• Signalling by insulin and IGF receptors: supporting acts and new players

  Kenneth Siddle

  579
  Citations

• Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity

  Yousuke Ebina;Eiichi Araki;Masato Taira;Fumio Shimada

  539
  Citations

• Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins

  W J Sobey;S F Beer;C A Carrington;P M Clark

  473
  Citations

• Tumor necrosis factor-alpha induces apoptosis of human adipose cells.

  Johannes B Prins;Carola U Niesler;Clay M Winterford;Nicholas A Bright

  467
  Citations

• Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting

  Elaine M. Bailyes;Barbara T. Navé;Maria A. Soos;Stephen R. Orr

  401
  Citations

• Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase.

  P R Shepherd;B T Navé;K Siddle

  363
  Citations

• Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation.

  Samira Benyoucef;Katharina H. Surinya;Dirk Hadaschik;Kenneth Siddle

  264
  Citations

• Grb10 and Grb14: enigmatic regulators of insulin action--and more?

  Lowenna J. Holt;Kenneth Siddle

  199
  Citations

• A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity.

  M. A. Soos;C. E. Field;R. Lammers;A. Ullrich

  197
  Citations

• Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances.

  Kenneth Siddle

  185
  Citations

• Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function.

  P A Wilden;C R Kahn;K Siddle;M F White

  184
  Citations

• Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.

  D Ferland-McCollough;Denise Fernandez-Twinn;IG Cannell;H David

  167
  Citations

• Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene.

  Yumiko Okubo;Ken Siddle;Helen Firth;Steve O’Rahilly

  165
  Citations

• Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants.

  R. Schumacher;M.A. Soos;J. Schlessinger;D. Brandenburg

  163
  Citations

• Human Preadipocytes Display a Depot-Specific Susceptibility to Apoptosis

  Carola U Niesler;Kenneth Siddle;Johannes B Prins

  159
  Citations

• The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins Gi and Go

  Richard M. O'Brien;Miles D. Houslay;Graeme Milligan;Kenneth Siddle

  156
  Citations

• Transdominant Inhibition of Tyrosine Kinase Activity in Mutant Insulin/ Insulin-Like Growth Factor I Hybrid Receptors

  Judith L. Treadway;Brian D. Morrison;Maria A. Soos;Kenneth Siddle

  137
  Citations

• The involvement of microRNAs in Type 2 diabetes.

  David Ferland-McCollough;Susan E. Ozanne;Kenneth Siddle;Anne E. Willis

  131
  Citations

• Two Naturally Occurring Insulin Receptor Tyrosine Kinase Domain Mutants Provide Evidence That Phosphoinositide 3-Kinase Activation Alone Is Not Sufficient for the Mediation of Insulin’s Metabolic and Mitogenic Effects

  Anna Krook;Jonathan P. Whitehead;Stephen P. Dobson;Matthew R. Griffiths

  130
  Citations