Richard M. O'Brien

Overview

Best Publications

• Regulation of gene expression by insulin.

  R. M. O'Brien;D. K. Granner

  1011
  Citations

• Characterization and immunobiology of house dust mite allergens.

  Wayne R. Thomas;Wendy-Anne Smith;Belinda J. Hales;Kristina L. Mills

  518
  Citations

• Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription

  Richard M. O'Brien;Peter C. Lucas;Claude D. Forest;Mark A. Magnuson

  410
  Citations

• Regulation of Phosphoenolpyruvate Carboxykinase and Insulin-like Growth Factor-binding Protein-1 Gene Expression by Insulin: THE ROLE OF WINGED HELIX/FORKHEAD PROTEINS

  Robert K. Hall;Tomoyuki Yamasaki;Tomas Kucera;Mary Waltner-Law

  340
  Citations

• Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes.

  R. M. O'brien;E. L. Noisin;Adisak Suwanichkul;T. Yamasaki

  281
  Citations

• Insulin-regulated gene expression.

  R. M. O'Brien;R. S. Streeper;J. E. Ayala;B. T. Stadelmaier

  276
  Citations

• Glucose-6-phosphatase Catalytic Subunit Gene Family

  John C. Hutton;Richard M. O'Brien

  225
  Citations

• Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

  Lynley D. Pound;Suparna A. Sarkar;Richard K. P. Benninger;Yingda Wang

  214
  Citations

• Phosphatidylinositol 3-Kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin: dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression

  Calum Sutherland;Richard M. O'Brien;Daryl K. Granner

  211
  Citations

• A Multicomponent Insulin Response Sequence Mediates a Strong Repression of Mouse Glucose-6-phosphatase Gene Transcription by Insulin

  Ryan S. Streeper;Christina A. Svitek;Stacey Chapman;Linda E. Greenbaum

  202
  Citations

• The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements.

  Beth T. Vander Kooi;Hiroshi Onuma;James K. Oeser;Christina A. Svitek

  185
  Citations

• Insulin Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression Does Not Require Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway

  Robert A. Gabbay;Calum Sutherland;Luigi Gnudi;Barbara B. Kahn

  179
  Citations

• A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene.

  Peter C. Lucas;Richard M. O'Brien;John A. Mitchell;Charles M. Davis

  175
  Citations

• Zinc transporter 8 (ZnT8) and β cell function.

  Howard W. Davidson;Janet M. Wenzlau;Richard M. O’Brien

  174
  Citations

• Molecular Physiology and Genetics of NIDDM: Importance of Metabolic Staging

  Daryl K Granner;Richard M O'Brien

  170
  Citations

• Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein.

  S D Arden;T Zahn;S Steegers;S Webb

  165
  Citations

• Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.

  J E Ayala;R S Streeper;J S Desgrosellier;S K Durham

  162
  Citations

• The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins Gi and Go

  Richard M. O'Brien;Miles D. Houslay;Graeme Milligan;Kenneth Siddle

  156
  Citations

• Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence.

  Claude D. Forest;Richard M. O'Brien;Peter C. Lucas;Mark A. Magnuson

  146
  Citations

• Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein

  CC Martin;JK Oeser;CA Svitek;SI Hunter

  128
  Citations