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Richard M. O'Brien

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
9661
World Ranking
16211
National Ranking
6717

Richard M. O'Brien publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Richard M. O'Brien sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 127 publications — 15th percentile

15% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Richard M. O'Brien D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Richard M. O'Brien sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 53 D-Index — 19th percentile

19% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Richard M. O'Brien is affiliated with Vanderbilt University in the United States. Their research primarily revolves around biochemistry, genetics, and molecular biology, with a particular focus on metabolism, diabetes, and pancreatic function. Their work spans related subfields such as molecular biology, genetics, surgery, and rheumatology.

The scientist has contributed extensively to the study of pancreatic function and diabetes, as well as glycogen storage diseases and myoclonus. Additional areas of research include genetics and neurodevelopmental disorders, ion transport and channel regulation, epigenetics, and DNA methylation.

Frequent publication venues where Richard M. O'Brien's work appears include the Journal of Molecular Endocrinology, the Journal of Biological Chemistry, Harvard Dataverse, Molecular Metabolism, and Diabetes.

Their recent papers encompass the following:

  • Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation, 2020, Endocrinology
  • Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose, 2020, Journal of Molecular Endocrinology
  • Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells, 2022, Journal of Biological Chemistry
  • Biophysical and functional properties of purified glucose-6-phosphatase catalytic subunit 1, 2021, Journal of Biological Chemistry
  • Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose, 2021, Journal of Biological Chemistry

Frequent coauthors collaborating with Richard M. O'Brien consist of:

  • James K. Oeser
  • Karin J. Bosma
  • Derek P. Claxton
  • Emily M. Hawes
  • Mohsin Rahim

The main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of focus are:

  • Molecular Biology
  • Genetics
  • Surgery
  • Rheumatology
  • Public Health, Environmental and Occupational Health

Their key research topics cover:

  • Metabolism, Diabetes, and Cancer
  • Pancreatic function and diabetes
  • Glycogen Storage Diseases and Myoclonus
  • Genetics and Neurodevelopmental Disorders
  • Diabetes and associated disorders
  • Ion Transport and Channel Regulation
  • Epigenetics and DNA Methylation

Best Publications

  • Regulation of gene expression by insulin.

    R. M. O'Brien;D. K. Granner

  • Characterization and immunobiology of house dust mite allergens.

    Wayne R. Thomas;Wendy-Anne Smith;Belinda J. Hales;Kristina L. Mills

  • Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription

    Richard M. O'Brien;Peter C. Lucas;Claude D. Forest;Mark A. Magnuson

  • Regulation of Phosphoenolpyruvate Carboxykinase and Insulin-like Growth Factor-binding Protein-1 Gene Expression by Insulin: THE ROLE OF WINGED HELIX/FORKHEAD PROTEINS

    Robert K. Hall;Tomoyuki Yamasaki;Tomas Kucera;Mary Waltner-Law

  • Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes.

    R. M. O'brien;E. L. Noisin;Adisak Suwanichkul;T. Yamasaki

  • Insulin-regulated gene expression.

    R. M. O'Brien;R. S. Streeper;J. E. Ayala;B. T. Stadelmaier

  • Glucose-6-phosphatase Catalytic Subunit Gene Family

    John C. Hutton;Richard M. O'Brien

  • Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

    Lynley D. Pound;Suparna A. Sarkar;Richard K. P. Benninger;Yingda Wang

  • Phosphatidylinositol 3-Kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin: dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression

    Calum Sutherland;Richard M. O'Brien;Daryl K. Granner

  • A Multicomponent Insulin Response Sequence Mediates a Strong Repression of Mouse Glucose-6-phosphatase Gene Transcription by Insulin

    Ryan S. Streeper;Christina A. Svitek;Stacey Chapman;Linda E. Greenbaum

  • The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements.

    Beth T. Vander Kooi;Hiroshi Onuma;James K. Oeser;Christina A. Svitek

  • Insulin Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression Does Not Require Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway

    Robert A. Gabbay;Calum Sutherland;Luigi Gnudi;Barbara B. Kahn

  • A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene.

    Peter C. Lucas;Richard M. O'Brien;John A. Mitchell;Charles M. Davis

  • Zinc transporter 8 (ZnT8) and β cell function.

    Howard W. Davidson;Janet M. Wenzlau;Richard M. O’Brien

  • Molecular Physiology and Genetics of NIDDM: Importance of Metabolic Staging

    Daryl K Granner;Richard M O'Brien

  • Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein.

    S D Arden;T Zahn;S Steegers;S Webb

  • Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.

    J E Ayala;R S Streeper;J S Desgrosellier;S K Durham

  • The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins Gi and Go

    Richard M. O'Brien;Miles D. Houslay;Graeme Milligan;Kenneth Siddle

  • Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence.

    Claude D. Forest;Richard M. O'Brien;Peter C. Lucas;Mark A. Magnuson

  • Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein

    CC Martin;JK Oeser;CA Svitek;SI Hunter

Frequent Co-Authors

Daryl K. Granner
Daryl K. Granner Vanderbilt University
John C. Hutton
John C. Hutton University of Colorado Denver
Wayne R. Thomas
Wayne R. Thomas Telethon Kids Institute
Kenneth Siddle
Kenneth Siddle University of Cambridge
Philippe Froguel
Philippe Froguel Imperial College London
Miles D. Houslay
Miles D. Houslay King's College London
Calum Sutherland
Calum Sutherland University of Dundee
Graeme Milligan
Graeme Milligan University of Glasgow
Jeremy M. Tavaré
Jeremy M. Tavaré University of Bristol
David W. Piston
David W. Piston Washington University in St. Louis

External Links

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Best Scientists Citing Richard M. O'Brien

Daryl K. Granner

Daryl K. Granner

Vanderbilt University

Publications: 42

Wayne R. Thomas

Wayne R. Thomas

Telethon Kids Institute

Publications: 29

Terry G. Unterman

Terry G. Unterman

University of Illinois at Chicago

Publications: 28

Guy A. Rutter

Guy A. Rutter

Imperial College London

Publications: 28

Richard W. Hanson

Richard W. Hanson

Case Western Reserve University

Publications: 27

Rudolf Valenta

Rudolf Valenta

Medical University of Vienna

Publications: 23

Leif Groop

Leif Groop

Lund University

Publications: 23

Calum Sutherland

Calum Sutherland

University of Dundee

Publications: 22

Morris F. White

Morris F. White

Boston Children's Hospital

Publications: 21

C. Ronald Kahn

C. Ronald Kahn

Harvard University

Publications: 19

Mark I. McCarthy

Mark I. McCarthy

Genentech

Publications: 19

Hideoki Ogawa

Hideoki Ogawa

Juntendo University

Publications: 17

Ko Okumura

Ko Okumura

Juntendo University

Publications: 17

Susanne Vrtala

Susanne Vrtala

Medical University of Vienna

Publications: 17

Domenico Accili

Domenico Accili

Columbia University

Publications: 17

Klaus H. Kaestner

Klaus H. Kaestner

University of Pennsylvania

Publications: 17

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