World's Best Scientists 2026 revealed!
Award Badge
Molecular Biology
USA
2026

D-Index & Metrics

Genetics

D-Index
135
Citations
57604
World Ranking
220
National Ranking
113

Molecular Biology

D-Index
135
Citations
57604
World Ranking
150
National Ranking
97

Medicine

D-Index
136
Citations
60219
World Ranking
1998
National Ranking
1137

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award

Overview

Klaus H. Kaestner is affiliated with the University of Pennsylvania in the United States. Their research spans multiple fields with a primary focus on Biochemistry, Genetics, and Molecular Biology as well as Medicine. They have contributed extensively to subfields including Molecular Biology, Genetics, Surgery, Endocrinology, Diabetes and Metabolism, and Immunology.

Their work covers several key topics such as pancreatic function and diabetes, diabetes and associated disorders, single-cell and spatial transcriptomics, diabetes management and research, epigenetics and DNA methylation, telomeres, telomerase, and senescence, and pancreatic and hepatic oncology research.

Kaestner has published numerous articles in various scientific journals. Some notable recent papers include:

  • Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis, 2020, Nature Genetics
  • β-Hydroxybutyrate suppresses colorectal cancer, 2022, Nature
  • Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets, 2021, Nature Communications
  • Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy, 2021, Nature Communications
  • SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells, 2020, Cell Metabolism

Their research output is frequently published in several venues that include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Diabetes
  • Nature Communications
  • Cellular and Molecular Gastroenterology and Hepatology
  • Gastroenterology

Kaestner collaborates regularly with a group of frequent co-authors, consisting of:

  • Ali Naji
  • Jonathan Schug
  • Daniel Traum
  • Catherine Lee May
  • Golnaz Vahedi

Best Publications

  • Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

    Han Cho;James Mu;Jason K. Kim;Jason K. Kim;Joanne L. Thorvaldsen

  • Unified nomenclature for the winged helix/forkhead transcription factors

    Klaus H. Kaestner;Walter Knöchel;Daniel E. Martínez

  • DNA binding of the glucocorticoid receptor is not essential for survival

    Holger M Reichardt;Klaus H Kaestner;Jan Tuckermann;Oliver Kretz

  • Cytoplasmic chromatin triggers inflammation in senescence and cancer

    Zhixun Dou;Kanad Ghosh;Maria Grazia Vizioli;Jiajun Zhu

  • Klf family members regulate intrinsic axon regeneration ability

    Jeffrey L. Goldberg;Vance P. Lemmon;John Bixby;Darcie Moore

  • Krüppel-like factor 4 regulates macrophage polarization

    Xudong Liao;Nikunj Sharma;Fehmida Kapadia;Guangjin Zhou

  • The evolution of Fox genes and their role in development and disease.

    Sridhar Hannenhalli;Klaus H. Kaestner

  • Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

    A.P. Monaghan;K.H. Kaestner;E. Grau;G. Schutz

  • Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis.

    Fereshteh Parviz;Christine Matullo;Wendy D Garrison;Laura Savatski

  • The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.

    Jonathan P. Katz;Nathalie Perreault;Bree G. Goldstein;Catherine S. Lee

  • The initiation of liver development is dependent on Foxa transcription factors.

    Catherine S. Lee;Joshua R. Friedman;James T. Fulmer;Klaus H. Kaestner

  • Severe impairment of spermatogenesis in mice lacking the CREM gene

    Julie A. Blendy;Klaus H. Kaestner;Gerhard F. Weinbauer;Eberhard Nieschlag

  • The Foxa family of transcription factors in development and metabolism

    J. R. Friedman;K. H. Kaestner

  • Cdx2 Ectopic Expression Induces Gastric Intestinal Metaplasia in Transgenic Mice

    Debra G. Silberg;Jessica Sullivan;Eugene Kang;Gary P. Swain

  • CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes.

    R J Christy;K H Kaestner;D E Geiman;M D Lane

  • Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase.

    J M Ntambi;S A Buhrow;K H Kaestner;R J Christy

  • Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.

    Luca Pellegrinet;Veronica Rodilla;Zhenyi Liu;Shuang Chen

  • Subepithelial telocytes are an important source of Wnts that supports intestinal crypts

    Michal Shoshkes-Carmel;Yue J Wang;Kirk J Wangensteen;Beáta Tóth

  • Expansion of β-cell mass in response to pregnancy

    Sebastian Rieck;Klaus H. Kaestner

  • Epigenomic plasticity enables human pancreatic α to β cell reprogramming

    Nuria C. Bramswig;Logan J. Everett;Jonathan Schug;Craig Dorrell

Frequent Co-Authors

Jonathan Schug
Jonathan Schug University of Pennsylvania
Ali Naji
Ali Naji University of Pennsylvania
Günther Schütz
Günther Schütz German Cancer Research Center
Alvin C. Powers
Alvin C. Powers Vanderbilt University Medical Center
Benjamin Glaser
Benjamin Glaser Hebrew University of Jerusalem
Franz M. Matschinsky
Franz M. Matschinsky University of Pennsylvania
Markus Grompe
Markus Grompe Oregon Health & Science University
Christian J. Stoeckert
Christian J. Stoeckert University of Pennsylvania
Vincent W. Yang
Vincent W. Yang Stony Brook University
Lori Sussel
Lori Sussel University of Colorado Denver

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring a career in molecular biology can open doors to diverse healthcare and research opportunities. Many students interested in this field also look into flexible degree options, such as direct entry MSN programs for non nurses online. These accelerated programs enable individuals from non-nursing backgrounds to transition into advanced nursing roles, drawing on biological sciences knowledge.

For those currently holding an RN license and considering further education, comparing wgu vs chamberlain for RN to BSN programs can help identify the best fit for your career goals and budget. Many students also pursue bridge options, and the rn to bsn to msn online programs pathway is a popular, cost-effective route to an advanced degree.

When choosing an online program, accreditation matters. Consider enrolling in courses from the non profit online universities ranked for academic quality and credibility. These institutions often offer robust science curricula and valuable career support for molecular biology graduates.

Best Scientists Citing Klaus H. Kaestner

Trending Scientists

Recently Published Articles