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C. A. A. Van Boeckel

C. A. A. Van Boeckel

D-Index & Metrics

Chemistry

D-Index
48
Citations
8335
World Ranking
15236
National Ranking
275

Overview

C. A. A. Van Boeckel is affiliated with Leiden University in the Netherlands and conducts research primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Pharmacology, Surgery, Endocrinology, Diabetes and Metabolism, Molecular Biology, and Physiology.

The scientist's research focuses on topics that include Cannabis and Cannabinoid Research, Pancreatic function and diabetes, Sleep and Wakefulness Research, Diet, Metabolism, and Disease, Cancer therapeutics and mechanisms, Antibiotic Resistance in Bacteria, and Antibiotics Pharmacokinetics and Efficacy.

They have published research in several notable scientific journals. Frequent publication venues are:

  • Journal of Medicinal Chemistry
  • Nature Chemical Biology
  • Nature Communications
  • Nature Chemistry
  • ACS Central Science

Recent publications authored or co-authored by Van Boeckel include:

  • "Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice," 2020, Nature Chemical Biology
  • "A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence," 2023, Nature Communications
  • "Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria," 2024, Nature Chemistry
  • "Structure-Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N-Acylphosphatidylethanolamine Phospholipase D," 2020, Journal of Medicinal Chemistry
  • "Structure-Activity Relationship Studies of Aryl Sulfoxides as Reversible Monoacylglycerol Lipase Inhibitors," 2024, Journal of Medicinal Chemistry

Van Boeckel frequently collaborates with several researchers, among whom are:

  • Mario van der Stelt
  • Ioli Kotsogianni
  • Tom van der Wel
  • Ming Jiang
  • Antonius P. A. Janssen

Best Publications

  • Chiral selection in poly(C)-directed synthesis of oligo(G)

    G. F. Joyce;G. M. Visser;C. A. A. van Boeckel;J. H. van Boom

  • The Unique Antithrombin III Binding Domain of Heparin: A Lead to New Synthetic Antithrombotics

    Constant A. A. van Boeckel;Maurice Petitou

  • USE OF THE CATIONIC IRIDIUM COMPLEX 1,5-CYCLOOCTADIENE-BIS(METHYLDIPHENYLPHOSPHINE)-IRIDIUM HEXAFLUOROPHOSPHATE IN CARBOHYDRATE CHEMISTRY: SMOOTH ISOMERIZATION OF ALLYL ETHERS TO 1-PROPENYL ETHERS

    J. J. Oltvoort;C. A. A. Van Boeckel;J. H. De Koning;J. H. Van Boom

  • Synthesis of a Pentasaccharide Corresponding to the Antithrombin III Binding Fragment of Heparin.

    C. A. A. Van Boeckel;T. Beetz;J. N. Vos;A. J. M. De Jong

  • Synthesis of a Pentasaccharide Corresponding to the Antithrombin III Binding Fragment of Heparin

    C. A.A. van Boeckel;T. Beetz;J. N. Vos;A. J.M. de Jong

  • Fondaparinux, a Synthetic Pentasaccharide: The First in a New Class of Antithrombotic Agents — The Selective Factor Xa Inhibitors

    Kenneth A Bauer;David W Hawkins;Paul C Peters;Maurice Petitou

  • A new approach to the synthesis of phosphotriester intermediates of nucleosides and nucleic acids

    G. van der Marel;C.A.A. van Boeckel;G. Wille;J.H. van Boom

  • A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy.

    Jeroen D. C. Codée;Bas Stubba;Marialuisa Schiattarella;Herman S. Overkleeft

  • Double Stereodifferentiation in Carbohydrate Coupling Reactions: The Mismatched Interaction of Donor and Acceptor as an Unprecedented Factor Governing the α/β Ratio of Glycoside Formation

    Unknown

  • Substituent effects on carbohydrate coupling reactions promoted by insoluble silver salts

    C.A.A. Van Boeckel;T. Beetz;S.F. Van Aelst

  • Chemoselective glycosylations using sulfonium triflate activator systems

    Jeroen D.C Codée;Leendert J van den Bos;Remy E.J.N Litjens;Herman S Overkleeft

  • Constructing a molecular model of the interaction between Antithrombin-III and a potent synthetic heparin Analogue.

    Pdj Grootenhuis;van Caa Constant Boeckel

  • The First Orally Active Low Molecular Weight Agonists for the LH Receptor: Thienopyr(im)idines with Therapeutic Potential for Ovulation Induction

    N. C. R. van Straten;G. G. Schoonus-Gerritsma;R. G. van Someren;J. Draaijer

  • Specific recognition of antibody-oligonucleotide conjugates by radiolabeled antisense nucleotides: a novel approach for two-step radioimmunotherapy of cancer.

    Wha Will Kuijpers;ES Bos;WS Kaspersen;GH Veeneman

  • SR 90107A/Org 31540, a Novel Anti‐Factor Xa Antithrombotic Agent

    J. M. Herbert;M. Petitou;J. C. Lormeau;R. Cariou

  • Hydrazinedithiocarbonate (HDTC) as a new reagent for the improved removal of chloroacetyl and bromoacetyl protective groups.

    C.A.A. van Boeckel;T. Beetz

  • The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

    Elma Mons;Elma Mons;Ineke D. C. Jansen;Jure Loboda;Bjorn R. van Doodewaerd

  • A mechanism for heparin-induced potentiation of antithrombin III

    C.A.A. van Boeckel;P.D.J. Grootenhuis;A. Visser

  • Conformational analysis of synthetic heparin-like oligosaccharides containing α-L-idopyranosyluronic acid†

    C. A. A. van Boeckel;S. F. van Aelst;G. N. Wagenaars;J.-R. Mellema

  • A review of the methods of chemical synthesis of sulphate and glucuronide conjugates

    F. M. Kaspersen;C. A. A. Van Boeckel

  • Synthetic trimer and tetramer of 3-beta-D-ribose-(1-1)-D-ribitol-5-phosphate conjugated to protein induce antibody responses to Haemophilus influenzae type b capsular polysaccharide in mice and monkeys.

    C. C. A. M. Peeters;D. Evenberg;P. Hoogerhout;H. Käyhty

  • Syntheses of heparin - like pentamers containing “opened” uronic acid moieties

    H. Lucas;J.E.M. Hasten;Th.G. van Dinther;D.G. Meuleman

Frequent Co-Authors

J. H. Van Boom
J. H. Van Boom Leiden University
G. A. Van Der Marel
G. A. Van Der Marel Leiden University
Jan Poolman
Jan Poolman Janssen (Belgium)
Hans Paulsen
Hans Paulsen Universität Hamburg
Frank Miedema
Frank Miedema Utrecht University
Hidde L. Ploegh
Hidde L. Ploegh Boston Children's Hospital
Andrew H.-J. Wang
Andrew H.-J. Wang Academia Sinica
H. van Bekkum
H. van Bekkum Delft University of Technology
Cornelis Altona
Cornelis Altona Leiden University
Jurriaan Huskens
Jurriaan Huskens University of Twente

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