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Chemistry

D-Index
66
Citations
15048
World Ranking
7303
National Ranking
422

Overview

Maurice Petitou is affiliated with the University of Cambridge in the United Kingdom. Their research spans several fields including biochemistry, genetics, molecular biology, and chemistry. They have contributed to various subfields such as organic chemistry, molecular biology, cell biology, infectious diseases, and immunology. Their work focuses extensively on carbohydrate chemistry and synthesis, proteoglycans and glycosaminoglycans research, glycosylation and glycoproteins research, SARS-CoV-2 and COVID-19 research, immunotherapy and immune responses, animal virus infections studies, and chemical synthesis and reactions.

Recent publications by Maurice Petitou include:

  • Evidence for Multiple Binding Modes in the Initial Contact Between SARS-CoV-2 Spike S1 Protein and Cell Surface Glycans, 2022, Chemistry - A European Journal
  • Degeneracy of the Antithrombin Binding Sequence in Heparin: 2-O-Sulfated Iduronic Acid Can Replace the Critical Glucuronic Acid, 2020, Chemistry - A European Journal
  • Efficient selective deacetylation of complex oligosaccharides using the neutral organotin catalyst [tBu2SnOH(Cl)]2, 2020, Carbohydrate Research
  • Synthetic glycol-split heparin tri- and tetrasaccharides provide new insights into structural peculiarities for antiheparanase activity, 2024, Bioorganic & Medicinal Chemistry
  • Chemoenzymatic Synthesis of D-Glucaro-δ-lactam Containing Oligosaccharides as Putative Heparanase Inhibitors, 2021, ChemistrySelect

Frequent coauthors collaborating with Maurice Petitou include:

  • Marco Guerrini
  • Minghong Ni
  • Stefano Elli
  • Annamaria Naggi
  • Michela Parafioriti

The scientist commonly publishes in venues such as:

  • Chemistry - A European Journal
  • Carbohydrate Research
  • Bioorganic & Medicinal Chemistry
  • ChemistrySelect
  • SSRN Electronic Journal

The research topics Maurice Petitou addresses cover:

  • Carbohydrate Chemistry and Synthesis
  • Proteoglycans and Glycosaminoglycans Research
  • Glycosylation and Glycoproteins Research
  • SARS-CoV-2 and COVID-19 Research
  • Immunotherapy and Immune Responses
  • Animal Virus Infections Studies
  • Chemical Synthesis and Reactions

Best Publications

  • Structure-activity relationship in heparin : a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

    J. Choay;M. Petitou;J.C. Lormeau;P. Sinaÿ

  • The anticoagulant activation of antithrombin by heparin.

    Lei Jin;Jan Pieter Abrahams;Jan Pieter Abrahams;Richard Skinner;Maurice Petitou

  • The Unique Antithrombin III Binding Domain of Heparin: A Lead to New Synthetic Antithrombotics

    Constant A. A. van Boeckel;Maurice Petitou

  • Synthesis of thrombin-inhibiting heparin mimetics without side effects

    Maurice Petitou;Jean-Pascal Hérault;André Bernat;Pierre-Alexandre Driguez

  • The structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence. Chemical and 13C nuclear-magnetic-resonance studies.

    B Casu;P Oreste;G Torri;G Zoppetti

  • Conformational flexibility: a new concept for explaining binding and biological properties of iduronic acid-containing glycosaminoglycans

    B. Casu;M. Petitou;M. Provasoli;P. Sinaÿ

  • Contribution of monosaccharide residues in heparin binding to antithrombin III.

    Donald H. Atha;Jean Claude Lormeau;Maurice Petitou;Robert D. Rosenberg

  • Structural studies on a biologically active hexasaccharide obtained from heparin.

    Jean Choay;Jean-Claude Lormeau;Maurice Petitou;Pierre Sinay

  • 1976-1983, a critical period in the history of heparin: the discovery of the antithrombin binding site.

    Maurice Petitou;Benito Casu;Ulf Lindahl

  • Total synthesis of a heparin pentasaccharide fragment having high affinity for antithrombin III

    Pierre Sinaÿ;Jean-Claude Jacquinet;Maurice Petitou;Philippe Duchaussoy

  • Conformer populations of L-iduronic acid residues in glycosaminoglycan sequences.

    Dino R. Ferro;Augusto Provasoli;Massimo Ragazzi;Benito Casu

  • Evidence for conformational equilibrium of the sulfated L-iduronate residue in heparin and in synthetic heparin mono- and oligo-saccharides: NMR and force-field studies

    Dino R. Ferro;Augusto. Provasoli;Massimo. Ragazzi;Giangiacomo. Torri

  • Mechanism of Heparin Activation of Antithrombin ROLE OF INDIVIDUAL RESIDUES OF THE PENTASACCHARIDE ACTIVATING SEQUENCE IN THE RECOGNITION OF NATIVE AND ACTIVATED STATES OF ANTITHROMBIN

    Umesh R. Desai;Maurice Petitou;Ingemar Björk;Steven T. Olson

  • Effect of fondaparinux on platelet activation in the presence of heparin-dependent antibodies: a blinded comparative multicenter study with unfractionated heparin

    Pierre Savi;Beng H. Chong;Andreas Greinacher;Yves Gruel

  • Large, tissue-regulated domain diversity of heparan sulfates demonstrated by phage display antibodies.

    Michel A.B.A. Dennissen;Guido J. Jenniskens;Martijn Pieffers;Elly M.M. Versteeg

  • Structural Determinants of the Capacity of Heparin to Inhibit the Proliferation of Vascular Smooth Muscle Cells. II. Evidence for a Pentasaccharide Sequence That Contains a 3-O-Sulfate Group

    John J. Castellot;Jean Choay;Jean-Claude Lormeau;Maurice Petitou

  • Fondaparinux, a Synthetic Pentasaccharide: The First in a New Class of Antithrombotic Agents — The Selective Factor Xa Inhibitors

    Kenneth A Bauer;David W Hawkins;Paul C Peters;Maurice Petitou

  • Binding and endocytosis of heparin by human endothelial cells in culture.

    Unknown

  • Synthesis of heparin fragments: A methyl α-pentaoside with high affinity for antithrombin III☆

    Maurice Petitou;Philippe Duchaussoy;Isidore Lederman;Jean Choay

  • Inhibition of leucocyte elastase by heparin and its derivatives.

    F Redini;J M Tixier;M Petitou;J Choay

  • Contribution of 3-O- and 6-O-sulfated glucosamine residues in the heparin-induced conformational change in antithrombin III.

    Donald H. Atha;Jean Claude Lormeau;Maurice Petitou;Robert D. Rosenberg

Frequent Co-Authors

Jean Choay
Jean Choay Centre national de la recherche scientifique, CNRS
Pierre Sinaÿ
Pierre Sinaÿ École Normale Supérieure
Jean-Marc Herbert
Jean-Marc Herbert Centre Hospitalier Universitaire de Tours
Giangiacomo Torri
Giangiacomo Torri Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni
Benito Casu
Benito Casu Istituto G. Ronzoni
Jawed Fareed
Jawed Fareed Loyola University Chicago
Robin W. Carrell
Robin W. Carrell University of Cambridge
Marco Guerrini
Marco Guerrini Istituto G. Ronzoni
Ingemar Björk
Ingemar Björk Swedish University of Agricultural Sciences
Anne Imberty
Anne Imberty Grenoble Alpes University

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