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Michael R. Eccles

Michael R. Eccles

D-Index & Metrics

Molecular Biology

D-Index
54
Citations
11537
World Ranking
2319
National Ranking
2

Overview

Michael R. Eccles is affiliated with the University of Otago in New Zealand. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Within these broader areas, their work focuses on subfields including Molecular Biology, Oncology, Cancer Research, Immunology, and Genetics.

The main topics of their scientific investigation include:

  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Cancer Immunotherapy and Biomarkers
  • RNA modifications and cancer
  • Cancer-related gene regulation
  • Immunotherapy and Immune Responses
  • Cancer Cells and Metastasis

Eccles has contributed to a variety of recent publications with a focus on cancer biology and epigenetics. Some notable papers include:

  • "Promoter DNA Hypermethylation and Paradoxical Gene Activation" (2020), published in Trends in Cancer
  • "Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy" (2020), published in Molecules
  • "Phenotype Switching and the Melanoma Microenvironment; Impact on Immunotherapy and Drug Resistance" (2023), published in International Journal of Molecular Sciences
  • "EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma" (2020), published in Journal of Investigative Dermatology
  • "Epigenetic basis and targeting of cancer metastasis" (2021), published in Trends in Cancer

Frequent co-authors who have collaborated with Eccles include:

  • Aniruddha Chatterjee
  • Euan J. Rodger
  • Peter A. Stockwell
  • Grégory Gimenez
  • Suzan Almomani

Eccles publishes regularly in several scientific venues with multiple works appearing in:

  • International Journal of Molecular Sciences
  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Oncology
  • Trends in Cancer

Best Publications

  • Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour

    Osamu Ogawa;Michael R. Eccles;Jenny Szeto;Leslie A. McNoe

  • Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux

    Phaikasame Sanyanusin;Lisa A. Schimmenti;Leslie A. McNoe;Teresa A. Ward

  • Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2

    Ethylin Wang Jabs;Xiang Li;Alan F. Scott;Gregory Meyers

  • Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells.

    Aleksandra Muratovska;Michael R Eccles

  • Expression of insulin-like growth factor-II transcripts in Wilms' tumour

    Anthony E. Reeve;Michael R. Eccles;Richard J. Wilkins;Graeme I. Bell

  • A PANorama of PAX genes in cancer and development

    Ewan J. D. Robson;Shu-Jie He;Michael R. Eccles

  • Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival

    Aleksandra Muratovska;Chaoming Zhou;Shuji He;Paul Goodyer

  • Epigenetic drivers of tumourigenesis and cancer metastasis.

    Aniruddha Chatterjee;Euan J. Rodger;Michael R. Eccles

  • Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media

    Britt Kunnen;Britt Kunnen;Callum Macdonald;Alexander Doronin;Steven Jacques

  • A Third Wilms' Tumor Locus on Chromosome 16q

    Marion A. Maw;Paul E. Grundy;Lynn J. Millow;Michael R. Eccles

  • Disruption of ROBO2 Is Associated with Urinary Tract Anomalies and Confers Risk of Vesicoureteral Reflux

    Weining Lu;Weining Lu;Albertien M. Van Eerde;Xueping Fan;Fabiola Quintero-Rivera

  • Primary renal hypoplasia in humans and mice with PAX2 mutations: evidence of increased apoptosis in fetal kidneys of Pax21Neu +/– mutant mice

    Sarah Porteous;Elena Torban;Nam-Pyo Cho;Heather Cunliffe

  • Mutation of PAX2 in two siblings with renal-coloboma syndrome

    Phaikasame Sanyanusin;L. A. Mcnoe;M. J. Sullivan;R. G. Weaver

  • Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy

    Abdullah Al Emran;Aniruddha Chatterjee;Euan J. Rodger;Jessamy C. Tiffen

  • Expression of the PAX2 gene in human fetal kidney and Wilms' tumor.

    Eccles Mr;Wallis Lj;Fidler Ae;Spurr Nk

  • Renal-coloboma syndrome: a multi-system developmental disorder caused by PAX2 mutations.

    Michael R Eccles;Lisa A Schimmenti

  • Promoter DNA Hypermethylation and Paradoxical Gene Activation

    Jim Smith;Swapnoleena Sen;Robert J. Weeks;Michael R. Eccles

  • Biallelic DICER1 mutations occur in Wilms tumours

    M.K. Wu;N. Sabbaghian;B. Xu;S. Addidou-Kalucki

  • Further delineation of renal-coloboma syndrome in patients with extreme variability of phenotype and identical PAX2 mutations.

    Lisa A. Schimmenti;Heather E. Cunliffe;Leslie A. McNoe;Teresa A. Ward

  • Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy

    Francesco Mainini;Michael R. Eccles

Frequent Co-Authors

Peter Hersey
Peter Hersey University of Sydney
Antony W. Braithwaite
Antony W. Braithwaite University of Otago
Osamu Ogawa
Osamu Ogawa Kyoto University
Bruce C. Baguley
Bruce C. Baguley University of Auckland
Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen
Ethylin Wang Jabs
Ethylin Wang Jabs Icahn School of Medicine at Mount Sinai
William B. Dobyns
William B. Dobyns University of Minnesota
Han G. Brunner
Han G. Brunner Radboud University
James F. Gusella
James F. Gusella Harvard University

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