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Biology and Biochemistry
New Zealand
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
23026
World Ranking
2750
National Ranking
5

Medicine

D-Index
87
Citations
22476
World Ranking
13801
National Ranking
27

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in New Zealand Leader Award
  • 2025 - Research.com Biology and Biochemistry in New Zealand Leader Award
  • 2023 - Research.com Biology and Biochemistry in New Zealand Leader Award
  • 2022 - Research.com Biology and Biochemistry in New Zealand Leader Award
  • 1991 - Fellow of the Royal Society of New Zealand

Overview

Bruce C. Baguley is affiliated with the University of Auckland in New Zealand. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with significant contributions also in medicine. Their subfields of study include molecular biology, oncology, immunology, cancer research, and cell biology.

The scientist's recent scholarly output encompasses diverse topics, reflecting a broad interest in molecular and cellular mechanisms relevant to disease. Notable research themes include epigenetics and DNA methylation, RNA regulation and disease, phagocytosis and immune regulation, autophagy in disease and therapy, cancer therapeutics and mechanisms, melanoma and MAPK pathways, and cutaneous melanoma detection and management.

Bruce C. Baguley has coauthored work frequently with several collaborators, including Euphemia Leung, Wayne R. Joseph, Maria L. Lotsberg, Salem Chouaïb, and James B. Lorens.

Their research has been published in various scientific venues, with multiple papers appearing in BMC Cancer and the journal Sci. Other journals featuring their work include bioRxiv (Cold Spring Harbor Laboratory), Journal of Thoracic Oncology, and Molecules.

Selected recent papers authored by or involving Bruce C. Baguley are:

  • AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells (2020, Journal of Thoracic Oncology)
  • Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer (2020, BMC Cancer)
  • DNA-Binding Anticancer Drugs: One Target, Two Actions (2021, Molecules)
  • Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK (2021, BMC Cancer)
  • Comparison of Global DNA Methylation Patterns in Human Melanoma Tissues and Their Derivative Cell Lines (2021, Cancers)

Bruce C. Baguley was awarded the status of Fellow of the Royal Society of New Zealand in 1991.

Best Publications

  • Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-intercalating agents which may not act via topoisomerase II.

    William A. Denny;Gordon W. Rewcastle;Bruce C. Baguley

  • POTENTIAL ANTITUMOR AGENTS. 34. QUANTITATIVE RELATIONSHIPS BETWEEN DNA BINDING AND MOLECULAR STRUCTURE FOR 9-ANILINOACRIDINES SUBSTITUTED IN THE ANILINO RING

    B. C. Baguley;W. A. Denny;G. J. Atwell;B. F. Cain

  • Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.

    Graham J. Atwell;Gordon W. Rewcastle;Bruce C. Baguley;William A. Denny

  • Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA).

    Christopher J. Portier;Bruce K Armstrong;Bruce C Baguley;Xaver Baur

  • Potential antitumor agents. 28. Deoxyribonucleic acid polyintercalating agents

    Bruce F. Cain;Bruce C. Baguley;William A. Denny

  • In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake.

    Johnson J. Liu;Peter Galettis;Alistair Farr;Lenushka Maharaj

  • DNA-Directed Alkylating Agents. 6. Synthesis and Antitumor Activity of DNA Minor Groove-Targeted Aniline Mustard Analogs of Pibenzimol (Hoechst 33258)

    Gravatt Gl;Baguley Bc;Wilson Wr;Denny Wa

  • Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma

    Christin E. Burd;Wenjin Liu;Minh V. Huynh;Meriam A. Waqas

  • Dual topoisomerase I/II inhibitors in cancer therapy.

    William A Denny;Bruce C Baguley

  • Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.

    Swarna A. Gamage;Julie A. Spicer;Graham J. Atwell;Graeme J. Finlay

  • Nucleolar damage correlates with neurotoxicity induced by different platinum drugs

    M J McKeage;T Hsu;D Screnci;G Haddad

  • Blood Flow Failure as a Major Determinant in the Antitumor Action of Flavone Acetic Acid

    L. Jonathan Zwi;Bruce C. Baguley;John B. Gavin;William R. Wilson

  • A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

    Stephen Jamieson;Jack U. Flanagan;Sharada Kolekar;Christina Buchanan

  • Papulacandin B: an inhibitor of glucan synthesis in yeast spheroplasts.

    Bruce C. Baguley;Günter Römmele;Johannes Gruner;Walter Wehrli

  • Multidrug resistance in cancer.

    Bruce C. Baguley

  • A mathematical model for analysis of the cell cycle in cell lines derived from human tumors.

    Britta Basse;Bruce C. Baguley;Elaine S. Marshall;Wayne R. Joseph

  • Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer.

    Mark J. McKeage;Bruce C. Baguley

  • Potential antitumor agents. 51. Synthesis and antitumor activity of substituted phenazine-1-carboxamides.

    Gordon W. Rewcastle;William A. Denny;Bruce C. Baguley

  • Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo.

    Gordon W. Rewcastle;Graham J. Atwell;Bruce C. Baguley;Stephen B. Calveley

  • Early stages of the apoptotic pathway in plant cells are reversible

    Iona E. W. O’brien;Bruce C. Baguley;Brian G. Murray;Bret A. M. Morris

Frequent Co-Authors

William A. Denny
William A. Denny University of Auckland
William R. Wilson
William R. Wilson University of Auckland
Lynnette R. Ferguson
Lynnette R. Ferguson University of Auckland
Brian D. Palmer
Brian D. Palmer University of Auckland
Peter R. Shepherd
Peter R. Shepherd University of Auckland
Shu-Feng Zhou
Shu-Feng Zhou Huaqiao University
Antony W. Braithwaite
Antony W. Braithwaite University of Otago
Michael R. Eccles
Michael R. Eccles University of Otago
Guangji Wang
Guangji Wang China Pharmaceutical University
Jun Lu
Jun Lu Zhejiang University

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