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Biology and Biochemistry

D-Index
55
Citations
19855
World Ranking
14763
National Ranking
6171

Overview

Florian L. Muller is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research focuses extensively on biochemistry, genetics, and molecular biology, with a total of 108 publications in this broad field. Additionally, Muller has an active body of work in medicine, contributing to 58 publications in this area.

Their subfields of study include molecular biology, infectious diseases, cancer research, genetics, and epidemiology. This diverse expertise supports research efforts spanning various biological mechanisms and disease contexts.

Key research topics addressed by Muller comprise:

  • Cancer, Hypoxia, and Metabolism
  • ATP Synthase and ATPases Research
  • SARS-CoV-2 and COVID-19 Research
  • Mitochondrial Function and Pathology
  • Biochemical and Molecular Research
  • COVID-19 Clinical Research Studies
  • Epigenetics and DNA Methylation

Muller has contributed to several frequently published venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Antimicrobial Agents and Chemotherapy
  • ACS Medicinal Chemistry Letters
  • Nature Metabolism

Their recent published papers illustrate the range of their research interests and impact:

  • NASH limits anti-tumour surveillance in immunotherapy-treated HCC, 2021, Nature
  • KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer, 2020, Cancer Cell
  • NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis, 2021, Cell Metabolism
  • Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment, 2020, ACS Medicinal Chemistry Letters
  • Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase, 2023, Science

Frequent collaborators in Muller's research include Victoria C. Yan, Yasaman Barekatain, Sunada Khadka, Cong-Dat Pham, and Yu-Hsi Lin. These partnerships reflect interconnected research networks spanning various scientific focuses.

Best Publications

  • Genomic Classification of Cutaneous Melanoma

    Rehan Akbani;Kadir C. Akdemir;B. Arman Aksoy;Monique Albert

  • Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.

    Qianghu Wang;Baoli Hu;Xin Hu;Xin Hu;Hoon Kim

  • Telomere dysfunction induces metabolic and mitochondrial compromise

    Ergiin Sahin;Simona Colla;Marc Liesa;Javid Moslehi

  • Trends in oxidative aging theories

    Florian L. Muller;Michael S. Lustgarten;Youngmok Jang;Arlan Richardson;Arlan Richardson

  • Complex III Releases Superoxide to Both Sides of the Inner Mitochondrial Membrane

    Florian L. Muller;Yuhong Liu;Holly Van Remmen

  • Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

    Andrea Viale;Piergiorgio Pettazzoni;Costas A. Lyssiotis;Haoqiang Ying

  • Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

    Mariela Jaskelioff;Florian L. Muller;Ji Hye Paik;Emily Thomas

  • An inhibitor of oxidative phosphorylation exploits cancer vulnerability.

    Jennifer R. Molina;Yuting Sun;Marina Protopopova;Sonal Gera

  • Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

    Florian L. Muller;Wook Song;Yuhong Liu;Asish Chaudhuri;Asish Chaudhuri

  • FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

    Ji hye Paik;Zhihu Ding;Rujuta Narurkar;Shakti Ramkissoon

  • Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

    Hoon Kim;Siyuan Zheng;Seyed S. Amini;Selene M. Virk

  • Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production.

    Florian L. Muller;Wook Song;Wook Song;Youngmok C. Jang;Yuhong Liu

  • Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

    Lawrence N Kwong;James C Costello;Huiyun Liu;Shan Jiang;Shan Jiang

  • Passenger deletions generate therapeutic vulnerabilities in cancer

    Florian L. Muller;Simona Colla;Elisa Aquilanti;Veronica E. Manzo

  • Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

    Youngmok C. Jang;Michael S. Lustgarten;Yuhong Liu;Florian L. Muller

  • The nature and mechanism of superoxide production by the electron transport chain: Its relevance to aging

    Florian Muller

  • The in vivo gene expression signature of oxidative stress

    Eun Soo Han;Florian L. Muller;Viviana I. Pérez;Wenbo Qi

  • Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging

    Abdellah Mansouri;Florian L. Muller;Yuhong Liu;Rainer Ng

  • Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

    Prasenjit Dey;Joelle Baddour;Florian Muller;Chia-Chin Wu

  • Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer.

    Yonathan Lissanu Deribe;Yuting Sun;Christopher Terranova;Fatima Khan

Frequent Co-Authors

Ronald A. DePinho
Ronald A. DePinho The University of Texas MD Anderson Cancer Center
Holly Van Remmen
Holly Van Remmen Oklahoma Medical Research Foundation
Arlan Richardson
Arlan Richardson University of Oklahoma Health Sciences Center
Giulio Draetta
Giulio Draetta The University of Texas MD Anderson Cancer Center
John M. Asara
John M. Asara Beth Israel Deaconess Medical Center
Edward F. Chang
Edward F. Chang University of California, San Francisco
Timothy P. Heffernan
Timothy P. Heffernan The University of Texas MD Anderson Cancer Center
Roel G.W. Verhaak
Roel G.W. Verhaak The Jackson Laboratory
Carlo Toniatti
Carlo Toniatti The University of Texas MD Anderson Cancer Center
Haoqiang Ying
Haoqiang Ying The University of Texas MD Anderson Cancer Center

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