World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
39062
World Ranking
2509
National Ranking
1319

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Giulio Draetta is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research primarily focuses on the intersection of biochemistry, genetics, and molecular biology, with 139 publications in these broad fields. Medicine is another main area of study, represented by 54 publications.

Their work spans several subfields, including molecular biology, cancer research, oncology, immunology, and cell biology. Molecular biology accounts for the largest portion with 82 publications, followed by cancer research with 44, and oncology with 24. Immunology and cell biology are also significant subfields of their scholarly activity.

The research topics explored by Giulio Draetta include:

  • Cancer Genomics and Diagnostics
  • Cancer, Hypoxia, and Metabolism
  • Single-cell and spatial transcriptomics
  • Pancreatic and Hepatic Oncology Research
  • Immune cells in cancer
  • Ubiquitin and proteasome pathways
  • RNA modifications and cancer

Some of their recent papers are:

  • Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells, 2020, The Journal of Experimental Medicine
  • Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells, 2021, Journal of Clinical Investigation
  • Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis, 2021, Science
  • Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer, 2021, Cancer Research
  • Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib, 2020, Cancer Research

Frequent coauthors who have collaborated extensively with Giulio Draetta include:

  • Giannicola Genovese
  • Timothy P. Heffernan
  • Alessandro Carugo
  • Ningping Feng
  • Luigi Perelli

Their most common publication venues are:

  • Cancer Research (35 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (11 publications)
  • Nature Communications (4 publications)
  • Journal of Medicinal Chemistry (3 publications)
  • Nature (2 publications)

Giulio Draetta is a member of the European Molecular Biology Organization (EMBO), reflecting recognition within the scientific community.

Best Publications

  • Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

    Michele Pagano;Sun W. Tam;Anne M. Theodoras;Peggy Beer-Romero

  • Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

    Véronique Baldin;Jiri Lukas;María Jesús Marcote;Michele Pagano

  • Cyclin A is required at two points in the human cell cycle.

    M. Pagano;R. Pepperkok;F. Verde;W. Ansorge

  • Genetics and biology of pancreatic ductal adenocarcinoma

    Haoqiang Ying;Prasenjit Dey;Wantong Yao;Alec C. Kimmelman

  • Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

    Loda M;Cukor B;Tam Sw;Lavin P

  • Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

    Andrea Viale;Piergiorgio Pettazzoni;Costas A. Lyssiotis;Haoqiang Ying

  • Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

    Giulio Draetta;David Beach

  • An inhibitor of oxidative phosphorylation exploits cancer vulnerability.

    Jennifer R. Molina;Yuting Sun;Marina Protopopova;Sonal Gera

  • Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis

    I Hoffmann;P R Clarke;M J Marcote;E Karsenti

  • Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF.

    Giulio Draetta;Frank Luca;Joanne Westendorf;Leonardo Brizuela

  • FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

    Jennifer O'Neil;Jonathan Grim;Peter Strack;Sudhir Rao

  • Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

    Alessia Montagnoli;Francesca Fiore;Esther Eytan;Andrea C. Carrano

  • Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

    Avnish Kapoor;Wantong Yao;Haoqiang Ying;Sujun Hua

  • CDC25 Phosphatases as Potential Human Oncogenes

    Konstantin Galaktionov;Arthur K. Lee;Jens Eckstein;Giulio Draetta

  • Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition.

    Ingrid Hoffmann;Giulio Draetta;Eric Karsenti

  • Regulating mammalian checkpoints through Cdc25 inactivation.

    Maddalena Donzelli;Giulio F Draetta

  • SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

    Luca Busino;Florian Bassermann;Alessio Maiolica;Choogon Lee

  • Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis

    Alex O. Morla;Giulio Draetta;David Beach;Jean Y.J. Wang

  • Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

    Luca Busino;Maddalena Donzelli;Massimo Chiesa;Daniele Guardavaccaro

  • The Cell Cycle Inhibitor p27 Is an Independent Prognostic Marker in Small (T1a,b) Invasive Breast Carcinomas

    Puay Tan;Blake Cady;Molly Wanner;Peter Worland

Frequent Co-Authors

Timothy P. Heffernan
Timothy P. Heffernan The University of Texas MD Anderson Cancer Center
Carlo Toniatti
Carlo Toniatti The University of Texas MD Anderson Cancer Center
Michele Pagano
Michele Pagano New York University
Ronald A. DePinho
Ronald A. DePinho The University of Texas MD Anderson Cancer Center
Haoqiang Ying
Haoqiang Ying The University of Texas MD Anderson Cancer Center
David Beach
David Beach Cold Spring Harbor Laboratory
Jason B. Fleming
Jason B. Fleming The University of Texas MD Anderson Cancer Center
Huamin Wang
Huamin Wang The University of Texas MD Anderson Cancer Center
Florian L. Muller
Florian L. Muller The University of Texas MD Anderson Cancer Center
Edward F. Chang
Edward F. Chang University of California, San Francisco

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