Her main research concerns Cell biology, Cell cycle, Ubiquitin ligase, Biochemistry and Cyclin-dependent kinase. Michele Pagano combines subjects such as Ubiquitin ligase complex, CUL1, Ubiquitin and DNA damage with her study of Cell biology. Her CUL1 study combines topics from a wide range of disciplines, such as Skp1, SCF ubiquitin ligase complex, S-Phase Kinase-Associated Proteins and SCF complex.
The Ubiquitin study which covers Proteolysis that intersects with Proteasome and Binding site. Her Cell cycle research is multidisciplinary, incorporating elements of Cancer research, Disease, Cell growth and Protein kinase A. Her Cyclin A2 research includes themes of Cyclin-dependent kinase complex and Cyclin E.
Her scientific interests lie mostly in Cell biology, Ubiquitin ligase, Ubiquitin, Cell cycle and Molecular biology. Her Cell biology study combines topics in areas such as Cyclin-dependent kinase, Cyclin A, Biochemistry and F-box protein. Michele Pagano combines subjects such as Cyclin-dependent kinase 1, Cyclin A2, Cyclin B, Cyclin E and Cyclin D with her study of Cyclin A.
Ubiquitin ligase is closely attributed to Protein subunit in her research. Her work deals with themes such as Protein degradation, Transcription factor, Proteolysis, Proteasome and Phosphorylation, which intersect with Ubiquitin. Her Cell cycle research includes elements of Cancer research, DNA damage and Cell growth.
Michele Pagano focuses on Cell biology, Ubiquitin ligase, Ubiquitin, Cyclin and Molecular biology. Michele Pagano interconnects Cell cycle, Gene silencing, Gene and DNA damage in the investigation of issues within Cell biology. Her Cell cycle research is multidisciplinary, incorporating elements of Cell growth, Activator and F-box protein.
Her Ubiquitin ligase research includes themes of Cancer cell, Protein subunit, Circadian clock, Metastasis and Repressor. Her Ubiquitin study integrates concerns from other disciplines, such as Protein degradation, SLBP, Proteasome, Regulation of gene expression and Cell fusion. Her study looks at the intersection of Cyclin and topics like Cyclin-dependent kinase with Cyclin B, Cell cycle checkpoint and SKP2.
Her primary areas of investigation include Cell biology, Ubiquitin ligase, Ubiquitin, Molecular biology and Cyclin. The concepts of her Cell biology study are interwoven with issues in Ubiquitin ligase complex, Cell cycle and DNA damage. Her study looks at the relationship between Cell cycle and topics such as F-box protein, which overlap with Degron, Casein kinase 2, G2-M DNA damage checkpoint and Cell division.
Michele Pagano has included themes like Ligand, Biophysics, Tensin, Calcium signaling and Protein structure in her Ubiquitin ligase study. Her Ubiquitin research is multidisciplinary, relying on both Proteolysis, Cancer research, Homologous recombination and Proteasome. Her studies deal with areas such as Polyadenylation, Messenger RNA and Gene as well as Molecular biology.
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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
Michele Pagano;Sun W. Tam;Anne M. Theodoras;Peggy Beer-Romero.
Cyclin D1 is a nuclear protein required for cell cycle progression in G1.
Véronique Baldin;Jiri Lukas;María Jesús Marcote;Michele Pagano.
Genes & Development (1993)
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.
Andrea C. Carrano;Esther Eytan;Avram Hershko;Michele Pagano.
Nature Cell Biology (1999)
Cyclin A is required at two points in the human cell cycle.
M. Pagano;R. Pepperkok;F. Verde;W. Ansorge.
The EMBO Journal (1992)
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Ning Zheng;Brenda A. Schulman;Brenda A. Schulman;Langzhou Song;Julie J. Miller.
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition.
Motoaki Ohtsubo;Anne M. Theodoras;Jill Schumacher;James M. Roberts.
Molecular and Cellular Biology (1995)
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.
Loda M;Cukor B;Tam Sw;Lavin P.
Nature Medicine (1997)
The SCF ubiquitin ligase: insights into a molecular machine
Timothy Cardozo;Michele Pagano.
Nature Reviews Molecular Cell Biology (2004)
Regulation of the Cdk Inhibitor p27 and Its Deregulation in Cancer
J. Slingerland;M. Pagano.
Journal of Cellular Physiology (2000)
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.
David Frescas;Michele Pagano.
Nature Reviews Cancer (2008)
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