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Molecular Biology

D-Index
114
Citations
62678
World Ranking
314
National Ranking
190

Biology and Biochemistry

D-Index
117
Citations
64309
World Ranking
711
National Ranking
452

Overview

Michele Pagano is affiliated with New York University in the United States and has made significant contributions in the fields of Biochemistry, Genetics, Molecular Biology, and Medicine. Their research spans over 100 publications, with notable focus areas including Molecular Biology, Cell Biology, Oncology, Epidemiology, and Pulmonary and Respiratory Medicine.

Their main topics of work cover a range of biological and medical subjects, such as:

  • Ubiquitin and proteasome pathways
  • Cancer-related molecular pathways
  • RNA modifications and cancer
  • Microtubule and mitosis dynamics
  • DNA repair mechanisms
  • Autophagy in disease and therapy
  • Endoplasmic reticulum stress and disease

Pagano has published extensively in several prominent journals. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances
  • Molecular Cell
  • Cell
  • eLife

Some of the scientist's recent papers include:

  • PHOTACs enable optical control of protein degradation (2020) in Science Advances
  • FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster (2020) in Molecular Cell
  • CRL4AMBRA1 is a master regulator of D-type cyclins (2021) in Nature
  • A membrane-associated MHC-I inhibitory axis for cancer immune evasion (2023) in Cell
  • AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity (2021) in Nature

Their frequent collaborators include Gergely Róna, Daniele Simoneschi, Antonio Marzio, Beatrix Ueberheide, and Qingyue Zhang. Collaboration often spans multiple publications demonstrating ongoing research partnerships.

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

    Michele Pagano;Sun W. Tam;Anne M. Theodoras;Peggy Beer-Romero

  • Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

    Véronique Baldin;Jiri Lukas;María Jesús Marcote;Michele Pagano

  • SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.

    Andrea C. Carrano;Esther Eytan;Avram Hershko;Michele Pagano

  • Cyclin A is required at two points in the human cell cycle.

    M. Pagano;R. Pepperkok;F. Verde;W. Ansorge

  • Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.

    Ning Zheng;Brenda A. Schulman;Brenda A. Schulman;Langzhou Song;Julie J. Miller

  • Human cyclin E, a nuclear protein essential for the G1-to-S phase transition.

    Motoaki Ohtsubo;Anne M. Theodoras;Jill Schumacher;James M. Roberts

  • Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

    Loda M;Cukor B;Tam Sw;Lavin P

  • The SCF ubiquitin ligase: insights into a molecular machine

    Timothy Cardozo;Michele Pagano

  • Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.

    David Frescas;Michele Pagano

  • Regulation of the Cdk Inhibitor p27 and Its Deregulation in Cancer

    J. Slingerland;M. Pagano

  • The F-box protein family.

    Edward T Kipreos;Michele Pagano

  • S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth

    N. Valerio Dorrello;Angelo Peschiaroli;Daniele Guardavaccaro;Nancy H. Colburn

  • Systematic analysis and nomenclature of mammalian F-box proteins

    Jianping Jin;Timothy Cardozo;Ruth C. Lovering;Stephen J. Elledge

  • Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

    Alessia Montagnoli;Francesca Fiore;Esther Eytan;Andrea C. Carrano

  • Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.

    Brenda A. Schulman;Andrea C. Carrano;Philip D. Jeffrey;Zachary Bowen

  • Mechanisms and function of substrate recruitment by F-box proteins

    Jeffrey R. Skaar;Julia K. Pagan;Michele Pagano

  • The cell-cycle regulatory protein Cks1 is required for SCF Skp2 -mediated ubiquitinylation of p27

    Dvora Ganoth;Gil Bornstein;Tun K. Ko;Brett Larsen

  • Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.

    Tarig Bashir;N. Valerio Dorrello;Virginia Amador;Daniele Guardavaccaro

  • Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase.

    Gil Bornstein;Joanna Bloom;Danielle Sitry-Shevah;Keiko Nakayama

Frequent Co-Authors

Michael P. Washburn
Michael P. Washburn University of Kansas
Giulio Draetta
Giulio Draetta The University of Texas MD Anderson Cancer Center
Massimo Loda
Massimo Loda Cornell University
Laurence Florens
Laurence Florens Stowers Institute for Medical Research
Yasusei Kudo
Yasusei Kudo University of Tokushima
Giorgio Inghirami
Giorgio Inghirami Cornell University
Roberto Chiarle
Roberto Chiarle Harvard University
Gerry Melino
Gerry Melino University of Rome Tor Vergata
Avram Hershko
Avram Hershko Technion – Israel Institute of Technology
Stephen J. Elledge
Stephen J. Elledge Harvard University

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