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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
11266
World Ranking
13253
National Ranking
5642

Overview

Hiroyuki Inuzuka is affiliated with Beth Israel Deaconess Medical Center in the United States. Their research spans multiple intersecting fields including Biochemistry, Genetics and Molecular Biology, with significant work also in Medicine. Within these broad domains, their primary subfields of study include Molecular Biology, Materials Chemistry, Oncology, Epidemiology, and Immunology.

Notably, Hiroyuki Inuzuka's research emphasizes several key topics such as ubiquitin and proteasome pathways, protein degradation and inhibitors, crystallization and solubility studies, X-ray diffraction in crystallography, autophagy in disease and therapy, crystallography and molecular interactions, and peptidase inhibition and analysis.

The scientist's publication record highlights recent papers that cover various aspects of molecular and cellular biology. These include:

  • Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy, 2020, Nature Cell Biology
  • Delayed fluorescence from inverted singlet and triplet excited states, 2022, Nature
  • Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle, 2020, Cell Research
  • Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1, 2023, Science
  • Necroptosis pathways in tumorigenesis, 2022, Seminars in Cancer Biology

Hiroyuki Inuzuka collaborates frequently with other researchers, indicating a strong network in their domain. Their most recurring co-authors include:

  • Wenyi Wei
  • Daigo Miyajima
  • Atsuko Nihonyanagi
  • Daisuke Hashizume
  • Jing Liu

Publication venues where Hiroyuki Inuzuka most frequently contributes research include The Cambridge Structural Database, Journal of the American Chemical Society, Seminars in Cancer Biology, Acta Materia Medica, and Cell Research. These venues reflect a significant focus on structural and chemical biology as well as cancer-related studies.

Best Publications

  • SCF FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

    Hiroyuki Inuzuka;Shavali Shaik;Ichiro Onoyama;Darning Gao

  • Roles of F-box proteins in cancer

    Zhiwei Wang;Pengda Liu;Hiroyuki Inuzuka;Wenyi Wei

  • Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

    Pengda Liu;Michael Begley;Wojciech Michowski;Hiroyuki Inuzuka

  • STO-609, a Specific Inhibitor of the Ca2+/Calmodulin-dependent Protein Kinase Kinase

    Hiroshi Tokumitsu;Hiroyuki Inuzuka;Yumi Ishikawa;Masahiko Ikeda

  • R-cadherin: A novel Ca2+-dependent cell-cell adhesion molecule expressed in the retina

    Hiroyuki Inuzuka;Seiji Miyatani;Masatoshi Takeichi

  • Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

    Daming Gao;Hiroyuki Inuzuka;Alan Tseng;Rebecca Y. Chin

  • Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

    Pengda Liu;Wenjian Gan;Hiroyuki Inuzuka;Adam S. Lazorchak

  • Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.

    Xiangpeng Dai;Wenjian Gan;Xiaoning Li;Xiaoning Li;Shangqian Wang

  • mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

    Daming Gao;Hiroyuki Inuzuka;Meng Kwang Marcus Tan;Hidefumi Fukushima

  • Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

    Yang Gao;Yang Gao;Naoe Taira Nihira;Naoe Taira Nihira;Naoe Taira Nihira;Xia Bu;Chen Chu

  • Phosphorylation by Casein Kinase I promotes the turnover of the Mdm2 oncoprotein via the SCFβ-TRCP ubiquitin ligase

    Hiroyuki Inuzuka;Alan Tseng;Daming Gao;Bo Zhai

  • Acetylation-Dependent Regulation of Skp2 Function

    Hiroyuki Inuzuka;Daming Gao;Lydia W.S. Finley;Wen Yang

  • SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression

    Wenjian Gan;Xiangpeng Dai;Andrea Lunardi;Zhen Li

  • SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.

    Jessica A. Gasser;Hiroyuki Inuzuka;Alan W. Lau;Wenyi Wei

  • pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.

    Jianping Guo;Abhishek A. Chakraborty;Pengda Liu;Wenjian Gan

  • Tumor Suppressor Functions of FBW7 in Cancer Development and Progression

    Zhiwei Wang;Hiroyuki Inuzuka;Jiateng Zhong;Jiateng Zhong;Lixin Wan

  • Proteomic Analysis of β1-Adrenergic Receptor Interactions with PDZ Scaffold Proteins

    Junqi He;Michele Bellini;Hiroyuki Inuzuka;Jianguo Xu

  • Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase

    Sang Hyun Min;Alan W. Lau;Tae Ho Lee;Hiroyuki Inuzuka

  • Cyclin C is a haploinsufficient tumour suppressor

    Na Li;Anne Fassl;Joel Chick;Hiroyuki Inuzuka

  • LMO3 Interacts with Neuronal Transcription Factor, HEN2, and Acts as an Oncogene in Neuroblastoma

    Mineyoshi Aoyama;Toshinori Ozaki;Hiroyuki Inuzuka;Daihachiro Tomotsune

Frequent Co-Authors

Wenyi Wei
Wenyi Wei Beth Israel Deaconess Medical Center
Satoshi Fukumoto
Satoshi Fukumoto Tohoku University
John M. Asara
John M. Asara Beth Israel Deaconess Medical Center
Hiroshi Tokumitsu
Hiroshi Tokumitsu Okayama University
Steven P. Gygi
Steven P. Gygi Harvard University
Alex Toker
Alex Toker Beth Israel Deaconess Medical Center
Pier Paolo Pandolfi
Pier Paolo Pandolfi Beth Israel Deaconess Medical Center
William G. Kaelin
William G. Kaelin Harvard University
Fazlul H. Sarkar
Fazlul H. Sarkar Wayne State University
Marc W. Kirschner
Marc W. Kirschner Harvard University

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