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Marc W. Kirschner

Marc W. Kirschner

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Best Scientists
2025
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Biology and Biochemistry
USA
2026

D-Index & Metrics

Best Scientists

D-Index
185
Citations
141863
World Ranking
511
National Ranking
331

Biology and Biochemistry

D-Index
187
Citations
146071
World Ranking
56
National Ranking
47

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2003 - E.B. Wilson Medal, American Society for Cell Biology
  • 2001 - Canada Gairdner International Award
  • 2000 - Member of Academia Europaea
  • 1999 - Fellow of the Royal Society, United Kingdom
  • 1996 - ASCB Public Service Award, The American Society for Cell Biology
  • 1991 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for elucidating key steps in the cell cycle chromosome movement cell cycle timing nucleus breakdown and reformation and microtubule control of cell polarity and mitosis.
  • 1989 - Fellow of the American Academy of Arts and Sciences
  • 1989 - Member of the National Academy of Sciences

Overview

Marc W. Kirschner is affiliated with Harvard University in the United States and specializes in Biochemistry, Genetics, and Molecular Biology. Their research spans several subfields including Molecular Biology, Biophysics, Cell Biology, Aging, and Genetics.

The scientist's recent publication record includes work in various highly regarded journals. Key papers include:

  • Noncanonical open reading frames encode functional proteins essential for cancer cell survival (2021, Nature Biotechnology)
  • Protein and lipid mass concentration measurement in tissues by stimulated Raman scattering microscopy (2022, Proceedings of the National Academy of Sciences)
  • Computational Models for Clinical Applications in Personalized Medicine-Guidelines and Recommendations for Data Integration and Model Validation (2022, Journal of Personalized Medicine)
  • Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss (2020, Molecular Cell)
  • Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation (2020, Proceedings of the National Academy of Sciences)

Frequent co-authors include:

  • Leonid Peshkin (20 joint publications)
  • Xili Liu (9 joint publications)
  • Seungeun Oh (7 joint publications)
  • Elizabeth Van Itallie (7 joint publications)
  • Matthew Sonnett (7 joint publications)

Marc W. Kirschner publishes often in several primary venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory) with 20 publications
  • Proceedings of the National Academy of Sciences with 4 publications
  • eLife with 3 publications
  • Developmental Biology with 2 publications
  • Biophysical Journal with 2 publications

The scientist's research topics focus on:

  • Wnt/β-catenin signaling in development and cancer
  • Microtubule and mitosis dynamics
  • RNA and protein synthesis mechanisms
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Cancer-related gene regulation
  • Cell Image Analysis Techniques
  • Genetics, Aging, and Longevity in Model Organisms

Marc W. Kirschner is also an author of at least one notable book publication: Normal Table of Xenopus Laevis (Daudin), published in 2020 by Garland Science eBooks, which has been cited extensively in the literature.

Their career recognition includes several awards and honors such as:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2009
  • E.B. Wilson Medal, American Society for Cell Biology, 2003
  • Canada Gairdner International Award, 2001
  • Member of Academia Europaea, 2000
  • Fellow of the Royal Society, United Kingdom, 1999
  • ASCB Public Service Award, The American Society for Cell Biology, 1996
  • Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences, 1991, for elucidating key steps in cell cycle chromosome movement, cell cycle timing, nucleus breakdown and reformation, and microtubule control of cell polarity and mitosis
  • Member of the National Academy of Sciences, 1989
  • Fellow of the American Academy of Arts and Sciences, 1989

Best Publications

  • Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

    Don W. Cleveland;Stuart G. Fischer;Marc W. Kirschner;Ulrich K. Laemmli

  • Dynamic instability of microtubule growth

    Tim Mitchison;Marc Kirschner

  • A protein factor essential for microtubule assembly

    Murray D. Weingarten;Arthur H. Lockwood;Shu-Ying Hwo;Marc W. Kirschner

  • Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

    Allon M. Klein;Linas Mazutis;Linas Mazutis;Ilke Akartuna;Naren Tallapragada

  • Cyclin is degraded by the ubiquitin pathway

    Michael Glotzer;Andrew W. Murray;Marc W. Kirschner

  • Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS

    Scott A. Gerber;John Rush;Olaf Stemman;Marc W. Kirschner

  • Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

    Shih Min A Huang;Yuji M. Mishina;Shanming Liu;Atwood Cheung

  • Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

    Don W. Cleveland;Margaret A. Lopata;Raymond J. MacDonald;Nicholas J. Cowan

  • A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage

    John Newport;Marc Kirschner

  • Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

    Srinivas Kothakota;Toshifumi Azuma;Toshifumi Azuma;Toshifumi Azuma;Christoph Reinhard;Christoph Reinhard;Christoph Reinhard;Anke Klippel;Anke Klippel;Anke Klippel

  • How proteolysis drives the cell cycle

    Randall W. King;Raymond J. Deshaies;Jan-Michael Peters;Marc W. Kirschner

  • The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.

    Rajat Rohatgi;Le Ma;Hiroaki Miki;Marco Lopez

  • Beyond self-assembly: from microtubules to morphogenesis

    Marc Kirschner;Tim Mitchison

  • Cyclin synthesis drives the early embryonic cell cycle.

    Andrew W. Murray;Marc W. Kirschner

  • Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

    Mohit Jain;Roland Nilsson;Sonia Sharma;Nikhil Madhusudhan;Nikhil Madhusudhan

  • Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos

    E. Amaya;T.J. Musci;M.W. Kirschner

  • The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

    Andrew W. Murray;Mark J. Solomon;Marc W. Kirschner

  • Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis

    Thomas J McGarry;Marc W Kirschner

  • Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

    D. N. Drechsel;A. A. Hyman;Melanie H Cobb;M. W. Kirschner

  • A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription.

    John Newport;Marc Kirschner

Frequent Co-Authors

John C. Gerhart
John C. Gerhart University of California, Berkeley
Timothy J. Mitchison
Timothy J. Mitchison Harvard University
Steven P. Gygi
Steven P. Gygi Harvard University
Randall W. King
Randall W. King Harvard University
Don W. Cleveland
Don W. Cleveland University of California, San Diego
P. Todd Stukenberg
P. Todd Stukenberg University of Virginia
Allon M. Klein
Allon M. Klein Harvard University
Michael Rape
Michael Rape University of California, Berkeley
Jan-Michael Peters
Jan-Michael Peters Research Institute of Molecular Pathology
Victor C. Li
Victor C. Li University of Michigan–Ann Arbor

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