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Biology and Biochemistry

D-Index
53
Citations
19729
World Ranking
15899
National Ranking
6604

Overview

Michael Rape is affiliated with the University of California, Berkeley in the United States and conducts research primarily in the field of Biochemistry, Genetics, and Molecular Biology. Their work spans several key subfields including Molecular Biology, Cell Biology, Epidemiology, Oncology, and Genetics.

The scientist has contributed notably to topics such as:

  • Ubiquitin and proteasome pathways
  • Protein Degradation and Inhibitors
  • Mitochondrial Function and Pathology
  • Genomics, phytochemicals, and oxidative stress
  • Microtubule and mitosis dynamics
  • Genomics and Chromatin Dynamics
  • Endoplasmic Reticulum Stress and Disease

Michael Rape frequently publishes in several scientific venues, with the most common including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Cell
  • Trends in Biochemical Sciences
  • Molecular Cell

Recent significant papers authored in collaboration with others are as follows:

  • Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications, 2022, Journal of the American Chemical Society
  • A Cellular Mechanism to Detect and Alleviate Reductive Stress, 2020, Cell
  • Structural basis and regulation of the reductive stress response, 2021, Cell
  • An E3 ligase guide to the galaxy of small-molecule-induced protein degradation, 2021, Cell chemical biology
  • Gene expression and cell identity controlled by anaphase-promoting complex, 2020, Nature

Frequent collaborators of Michael Rape include:

  • Kevin G. Mark
  • Andrew G. Manford
  • Diane L. Haakonsen
  • Brenda Martínez-González
  • David Akopian

Best Publications

  • The Ubiquitin Code

    David Komander;Michael Rape

  • Building ubiquitin chains: E2 enzymes at work.

    Yihong Ye;Michael Rape

  • The increasing complexity of the ubiquitin code

    Richard Yau;Michael Rape

  • Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing

    Thorsten Hoppe;Kai Matuschewski;Michael Rape;Stephan Schlenker

  • A Series of Ubiquitin Binding Factors Connects CDC48/p97 to Substrate Multiubiquitylation and Proteasomal Targeting

    Holger Richly;Michael Rape;Sigurd Braun;Sebastian Rumpf

  • Mechanism of Ubiquitin-Chain Formation by the human Anaphase-Promoting Complex

    Lingyan Jin;Adam Williamson;Sudeep Banerjee;Isabelle Philipp

  • Mobilization of Processed, Membrane-Tethered SPT23 Transcription Factor by CDC48UFD1/NPL4, a Ubiquitin-Selective Chaperone

    Michael Rape;Thorsten Hoppe;Ingo Gorr;Marian Kalocay

  • Ubiquitylation at the crossroads of development and disease.

    Michael Rape

  • Enhanced protein degradation by branched ubiquitin chains

    Hermann-Josef Meyer;Michael Rape

  • K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

    Marissa L. Matsumoto;Katherine E. Wickliffe;Ken C. Dong;Christine Yu

  • Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

    Frank Stegmeier;Michael Rape;Michael Rape;Viji M. Draviam;Viji M. Draviam;Grzegorz Nalepa

  • Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

    S. K. Reddy;M. Rape;M. Rape;W. A. Margansky;M. W. Kirschner

  • Role of the ubiquitin‐selective CDC48UFD1/NPL4 chaperone (segregase) in ERAD of OLE1 and other substrates

    Sigurd Braun;Kai Matuschewski;Michael Rape;Sven Thoms;Sven Thoms

  • Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry

    Michael Rape;Marc W. Kirschner

  • Ubiquitin-dependent regulation of COPII coat size and function

    Lingyan Jin;Kanika Bajaj Pahuja;Katherine E. Wickliffe;Amita Gorur

  • Principles of Ubiquitin-Dependent Signaling.

    Eugene Oh;David Akopian;Michael Rape

  • The Processivity of Multiubiquitination by the APC Determines the Order of Substrate Degradation

    Michael Rape;Sashank K. Reddy;Marc W. Kirschner

  • Identification of a physiological E2 module for the human anaphase-promoting complex.

    Adam Williamson;Katherine E. Wickliffe;Barbara G. Mellone;Ling Song

  • The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

    Katherine E. Wickliffe;Sonja Lorenz;David E. Wemmer;David E. Wemmer;John Kuriyan

  • Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.

    Richard G. Yau;Richard G. Yau;Kerstin Doerner;Erick R. Castellanos;Diane L. Haakonsen;Diane L. Haakonsen

Frequent Co-Authors

Marc W. Kirschner
Marc W. Kirschner Harvard University
Stefan Jentsch
Stefan Jentsch Max Planck Society
John Kuriyan
John Kuriyan Vanderbilt University
Titia K. Sixma
Titia K. Sixma Antoni van Leeuwenhoek Hospital
J. Wade Harper
J. Wade Harper Harvard Medical School
Stephen J. Elledge
Stephen J. Elledge Harvard University
Daniel K. Nomura
Daniel K. Nomura University of California, Berkeley
Anthony T. Iavarone
Anthony T. Iavarone University of California, Berkeley
Donald C. Rio
Donald C. Rio University of California, Berkeley

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