Michael Rape mostly deals with Cell biology, Ubiquitin, Biochemistry, Anaphase-promoting complex and Ubiquitin ligase. His Ubiquitin research incorporates themes from Cell signaling, Signal transduction and Cell division. Ubiquitin-conjugating enzyme, Transcription factor, Proteasome and Enzyme are subfields of Biochemistry in which his conducts study.
His Ubiquitin-conjugating enzyme study incorporates themes from Deubiquitinating enzyme and SUMO enzymes. His Anaphase-promoting complex study combines topics from a wide range of disciplines, such as Spindle checkpoint and Mitotic checkpoint complex. The Ubiquitin ligase study which covers Plasma protein binding that intersects with Nuclear protein, Cell membrane and Regulon.
Michael Rape spends much of his time researching Cell biology, Ubiquitin, Ubiquitin ligase, Biochemistry and Ubiquitin-conjugating enzyme. His Cell biology research includes themes of Cell cycle, Cell division and Anaphase-promoting complex. Particularly relevant to Deubiquitinating enzyme is his body of work in Ubiquitin.
His Ubiquitin ligase research is multidisciplinary, incorporating elements of Plasma protein binding, Protein degradation, Cell fate determination and Neural crest. Within one scientific family, he focuses on topics pertaining to Crystal structure under Biochemistry, and may sometimes address concerns connected to Stereochemistry. His Ubiquitin-conjugating enzyme research incorporates elements of Processivity, Ubiquitin-Protein Ligases, Ubiquitins and Active site.
His primary areas of investigation include Ubiquitin, Cell biology, Ubiquitin ligase, Biophysics and Mitosis. His research in Ubiquitin focuses on subjects like Transcription factor, which are connected to Medulloblastoma and Pediatric cancer. He works in the field of Cell biology, namely Proteasome.
His Ubiquitin ligase study combines topics from a wide range of disciplines, such as Small molecule, Protein degradation and Drug discovery. Michael Rape interconnects Proteostasis and Protein folding in the investigation of issues within Biophysics. His study in Mitosis is interdisciplinary in nature, drawing from both Receptor, Mitotic exit, Cell cycle and Cell division.
His main research concerns Cell biology, Ubiquitin, Branching, Virulence and Bacterial outer membrane. The study incorporates disciplines such as Anaphase-promoting complex and Small molecule in addition to Cell biology. His Anaphase-promoting complex study integrates concerns from other disciplines, such as Mitosis and Proteasome.
The Small molecule study combines topics in areas such as Rational design, Enhancer, Transcription factor, DNA ligase and Substrate Interaction. Michael Rape combines topics linked to Ubiquitin ligase with his work on Rational design. Michael Rape has researched Virulence in several fields, including Immune system and Intracellular parasite.
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The Ubiquitin Code
David Komander;Michael Rape.
Annual Review of Biochemistry (2012)
Building ubiquitin chains: E2 enzymes at work.
Yihong Ye;Michael Rape.
Nature Reviews Molecular Cell Biology (2009)
The increasing complexity of the ubiquitin code
Richard Yau;Michael Rape.
Nature Cell Biology (2016)
Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing
Thorsten Hoppe;Kai Matuschewski;Michael Rape;Stephan Schlenker.
A Series of Ubiquitin Binding Factors Connects CDC48/p97 to Substrate Multiubiquitylation and Proteasomal Targeting
Holger Richly;Michael Rape;Sigurd Braun;Sebastian Rumpf.
Mechanism of Ubiquitin-Chain Formation by the human Anaphase-Promoting Complex
Lingyan Jin;Adam Williamson;Sudeep Banerjee;Isabelle Philipp.
Mobilization of Processed, Membrane-Tethered SPT23 Transcription Factor by CDC48UFD1/NPL4, a Ubiquitin-Selective Chaperone
Michael Rape;Thorsten Hoppe;Ingo Gorr;Marian Kalocay.
K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody
Marissa L. Matsumoto;Katherine E. Wickliffe;Ken C. Dong;Christine Yu.
Molecular Cell (2010)
Enhanced protein degradation by branched ubiquitin chains
Hermann-Josef Meyer;Michael Rape.
Role of the ubiquitin‐selective CDC48UFD1/NPL4 chaperone (segregase) in ERAD of OLE1 and other substrates
Sigurd Braun;Kai Matuschewski;Michael Rape;Sven Thoms;Sven Thoms.
The EMBO Journal (2002)
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