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Biology and Biochemistry

D-Index
50
Citations
15814
World Ranking
17430
National Ranking
1203

Overview

Thomas Sommer is affiliated with the Max Delbrück Center for Molecular Medicine in Germany. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a significant focus on medicine. Within these areas, Sommer's work touches on several specialized subfields, including molecular biology, cell biology, epidemiology, oncology, and cardiology and cardiovascular medicine.

The scientist's publications emphasize a range of biological processes and mechanisms. Main topics covered in their research include:

  • Ubiquitin and proteasome pathways
  • Autophagy in disease and therapy
  • Muscle physiology and disorders
  • Endoplasmic reticulum stress and disease
  • Protein degradation and inhibitors
  • Peptidase inhibition and analysis
  • Photosynthetic processes and mechanisms

Sommer has contributed to a diverse set of peer-reviewed articles, often collaborating with a core group of frequent co-authors. These include Ernst Jarosch, Oliver Popp, Lukas Pluska, Anita Waltho, and Volker Dötsch.

Key recent publications reflect a focus on protein degradation pathways and ubiquitin biology:

  • "Mechanisms of substrate processing during ER-associated protein degradation," 2023, Nature Reviews Molecular Cell Biology
  • "Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly-ubiquitylation," 2020, The EMBO Journal
  • "The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63-branched ubiquitin chains," 2021, The EMBO Journal
  • "The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies," 2023, Clinical Research in Cardiology
  • "K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors," 2024, Life Science Alliance

Sommer's articles have appeared in several publication venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The EMBO Journal
  • Methods in molecular biology
  • Nature Reviews Molecular Cell Biology
  • Clinical Research in Cardiology

Best Publications

  • ERAD: the long road to destruction

    Birgit Meusser;Christian Hirsch;Ernst Jarosch;Thomas Sommer

  • Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

    Yasuyuki Fujita;Gerd Krause;Martin Scheffner;Dietmar Zechner

  • Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

    Richard K. Plemper;Sigrun Böhmler;Javier Bordallo;Thomas Sommer

  • Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

    Ernst Jarosch;Christof Taxis;Corinna Volkwein;Javier Bordallo

  • Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms.

    Alexander Buchberger;Bernd Bukau;Thomas Sommer

  • A regulatory link between ER-associated protein degradation and the unfolded-protein response.

    Ruth Friedlander;Ernst Jarosch;Jörg Urban;Corinna Volkwein

  • Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system.

    Ingo Amm;Thomas Sommer;Dieter H. Wolf

  • Role of Cue1p in Ubiquitination and Degradation at the ER Surface

    Thomas Biederer;Corinna Volkwein;Thomas Sommer

  • Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor

    Ping Chen;Phoebe Johnson;Thomas Sommer;Stefan Jentsch

  • The Ubiquitin–Proteasome System of Saccharomyces cerevisiae

    Daniel Finley;Helle D. Ulrich;Thomas Sommer;Peter Kaiser

  • The ubiquitylation machinery of the endoplasmic reticulum

    Christian Hirsch;Robert Gauss;Sabine C. Horn;Oliver Neuber;Oliver Neuber

  • A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

    Thomas Sommer;Stefan Jentsch

  • Ubx2 links the Cdc48 complex to ER-associated protein degradation

    Oliver Neuber;Ernst Jarosch;Corinna Volkwein;Jan Walter;Jan Walter

  • Evolutionary conservation of components of the protein translocation complex

    Enno Hartmann;Thomas Sommer;Siegfried Prehn;Dirk Görlich

  • Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.

    T Biederer;C Volkwein;T Sommer

  • Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum

    Simone Clerc;Christian Hirsch;Daniela Maria Oggier;Paola Deprez

  • Endoplasmic reticulum degradation: reverse protein flow of no return.

    Thomas Sommer;Dieter H. Wolf

  • A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery

    Robert Gauss;Ernst Jarosch;Thomas Sommer;Christian Hirsch

  • A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae.

    K. Finke;K. Plath;S. Panzner;S. Prehn

  • Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life

    Martin S. Denzel;Nadia J. Storm;Aljona Gutschmidt;Ruth Baddi

Frequent Co-Authors

Aaron Ciechanover
Aaron Ciechanover Technion – Israel Institute of Technology
Dieter H. Wolf
Dieter H. Wolf University of Stuttgart
Peter Güntert
Peter Güntert ETH Zurich
Stefan Jentsch
Stefan Jentsch Max Planck Society
Udo Heinemann
Udo Heinemann Max Delbrück Center for Molecular Medicine
Gunnar Dittmar
Gunnar Dittmar Luxembourg Institute of Health
Enno Hartmann
Enno Hartmann University of Lübeck
Volker Dötsch
Volker Dötsch Goethe University Frankfurt
Daniel Finley
Daniel Finley Harvard University
Michael H. Glickman
Michael H. Glickman Technion – Israel Institute of Technology

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