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Biology and Biochemistry

D-Index
41
Citations
7876
World Ranking
19548
National Ranking
7966

Overview

Jagesh V. Shah is a researcher affiliated with Harvard University in the United States. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on Molecular Biology, Genetics, Oncology, Cell Biology, and Physiology as subfields of study.

Their research topics include virus-based gene therapy, CAR-T cell therapy, viral infectious diseases and gene expression in insects, erythrocyte function and pathophysiology, ion channel regulation and function, ubiquitin and proteasome pathways, and microtubule and mitosis dynamics.

Jagesh V. Shah has contributed to several recent papers, including:

  • Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence (2020, BMC Cancer)
  • Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles (2024, Molecular Therapy - Nucleic Acids)
  • Piezo mechanosensory channels regulate centrosome integrity and mitotic entry (2022, Proceedings of the National Academy of Sciences)
  • In vivo chimeric antigen receptor (CAR)-T cell therapy (2025, Nature Reviews Drug Discovery)
  • CD8-Targeted, Integrating Viral Vectors Transduce Resting T Cells and Enable Extracorporeal Delivery (ECD) for Rapid CAR T Cell Therapies (2022, Blood)

Frequent co-authors in their publications include Terry J. Fry, Shirisha Amatya, Albert Ruzo, Kutlu G. Elpek, and Lauren R. Pepper.

Jagesh V. Shah has published notably in the journal Blood, with six publications, as well as in bioRxiv (Cold Spring Harbor Laboratory), Molecular Therapy - Nucleic Acids, Proceedings of the National Academy of Sciences, and Nature Reviews Drug Discovery.

Best Publications

  • Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury.

    Li Yang;Tatiana Y Besschetnova;Tatiana Y Besschetnova;Craig R Brooks;Jagesh V Shah;Jagesh V Shah;Jagesh V Shah

  • Waiting for Anaphase: Mad2 and the Spindle Assembly Checkpoint

    Jagesh V. Shah;Don W. Cleveland

  • THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

    Pamela V Tran;Courtney J Haycraft;Tatiana Y Besschetnova;Annick Turbe-Doan

  • Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation

    Tatiana Y. Besschetnova;Elona Kolpakova-Hart;Yinghua Guan;Yinghua Guan;Jing Zhou

  • Dynamics of Centromere and Kinetochore Proteins: Implications for Checkpoint Signaling and Silencing

    Jagesh V Shah;Elliot Botvinick;Elliot Botvinick;Zahid Bonday;Frank Furnari

  • Centromere Identity Maintained by Nucleosomes Assembled with Histone H3 Containing the CENP-A Targeting Domain

    Ben E. Black;Lars E.T. Jansen;Lars E.T. Jansen;Paul S. Maddox;Paul S. Maddox;Daniel R. Foltz;Daniel R. Foltz

  • Defects in the IFT-B Component IFT172 Cause Jeune and Mainzer-Saldino Syndromes in Humans

    Jan Halbritter;Albane A. Bizet;Miriam Schmidts;Jonathan D. Porath

  • Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

    Nicholas Kwiatkowski;Nannette Jelluma;Panagis Filippakopoulos;Meera Soundararajan

  • The quantitative architecture of centromeric chromatin

    Dani L. Bodor;João F. Mata;Mikhail Sergeev;Mikhail Sergeev;Ana Filipa David

  • Bidirectional Translocation of Neurofilaments along Microtubules Mediated in Part by Dynein/Dynactin

    Jagesh V. Shah;Jagesh V. Shah;Lisa A. Flanagan;Paul A. Janmey;Jean-François Leterrier

  • The ciliary transition zone: from morphology and molecules to medicine

    Peter G. Czarnecki;Jagesh V. Shah;Jagesh V. Shah

  • Nuclear Pores Protect Genome Integrity by Assembling a Premitotic and Mad1-Dependent Anaphase Inhibitor

    Veronica Rodriguez-Bravo;John Maciejowski;Jennifer Corona;Håkon Kirkeby Buch;Håkon Kirkeby Buch

  • Strain hardening of fibrin gels and plasma clots

    Jagesh V. Shah;Paul A. Janmey

  • Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli.

    Xingjian Jin;Ashraf M. Mohieldin;Brian S. Muntean;Jill A. Green

  • Activation and control of p53 tetramerization in individual living cells.

    Giorgio Gaglia;Yinghua Guan;Yinghua Guan;Jagesh V. Shah;Jagesh V. Shah;Galit Lahav

  • Unstable microtubule capture at kinetochores depleted of the centromere‐associated protein CENP‐F

    Pascale Bomont;Paul Samuel Maddox;Jagesh V. Shah;Arshad B. Desai

  • Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks

    Dong-Hyun Lee;Sanket S. Acharya;Mijung Kwon;Pascal Drane

  • Slow axonal transport: fast motors in the slow lane

    Jagesh V Shah;Don W Cleveland

  • Controlled Ablation of Microtubules Using a Picosecond Laser

    E.L. Botvinick;E.L. Botvinick;V. Venugopalan;J.V. Shah;L.H. Liaw

  • Systematic VCP-UBXD Adaptor Network Proteomics Identifies a Role for UBXN10 in Regulating Ciliogenesis

    Malavika Raman;Mikhail Sergeev;Maija Garnaas;John R. Lydeard

Frequent Co-Authors

Michael W. Berns
Michael W. Berns University of California, Irvine
Don W. Cleveland
Don W. Cleveland University of California, San Diego
Paul A. Janmey
Paul A. Janmey University of Pennsylvania
Joseph V. Bonventre
Joseph V. Bonventre Brigham and Women's Hospital
Victor S. Goldmacher
Victor S. Goldmacher ImmunoGen (United States)
David R. Beier
David R. Beier Seattle Children's Hospital
Paul S. Maddox
Paul S. Maddox University of North Carolina at Chapel Hill
Ben E. Black
Ben E. Black University of Pennsylvania
Arshad Desai
Arshad Desai University of California, San Diego
Emma L. Duncan
Emma L. Duncan University of Queensland

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