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Biology and Biochemistry

D-Index
58
Citations
12899
World Ranking
13115
National Ranking
5592

Overview

Ben E. Black is a researcher affiliated with the University of Pennsylvania in the United States. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology and Plant Science as key subfields. Their scientific investigations also extend into Cell Biology, Oncology, and Genetics.

Their research topics cover several areas, including:

  • Chromosomal and Genetic Variations
  • Genomics and Chromatin Dynamics
  • Microtubule and mitosis dynamics
  • PARP inhibition in cancer therapy
  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • RNA Research and Splicing

Ben E. Black has contributed extensively to the scientific literature, with notable recent publications including:

  • Structural basis for allosteric PARP-1 retention on DNA breaks (2020) published in Science
  • Rapid Detection and Signaling of DNA Damage by PARP-1 (2021) published in Trends in Biochemical Sciences
  • The centromere comes into focus: from CENP-A nucleosomes to kinetochore connections with the spindle (2020) published in Open Biology
  • HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications (2021) published in Nature Communications
  • Epigenetic, genetic and maternal effects enable stable centromere inheritance (2022) published in Nature Cell Biology

Frequent collaborators in their research include Michael A. Lampson, Kathryn Kixmoeller, Praveen Kumar Allu, Craig W. Gambogi, and Glennis A. Logsdon.

Their work has appeared in several publication venues, with multiple contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Nature Communications
  • Current Biology
  • The FASEB Journal

This profile reflects a research portfolio characterized by interdisciplinary approaches linking molecular mechanisms with cellular dynamics and genetic regulation. The scientist's work addresses fundamental questions in DNA damage response, chromosome biology, and genetic engineering technologies.

Best Publications

  • The human CENP-A centromeric nucleosome-associated complex

    Daniel R. Foltz;Lars E. T. Jansen;Ben E. Black;Aaron O. Bailey

  • Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

    Daniel R. Foltz;Daniel R. Foltz;Lars E.T. Jansen;Lars E.T. Jansen;Aaron O. Bailey;John R. Yates

  • Propagation of centromeric chromatin requires exit from mitosis

    Lars E.T. Jansen;Ben E. Black;Ben E. Black;Daniel R. Foltz;Don W. Cleveland

  • Structural determinants for generating centromeric chromatin

    Ben E. Black;Daniel R. Foltz;Daniel R. Foltz;Srinivas Chakravarthy;Karolin Luger

  • Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality

    Michael J. Mina;Michael J. Mina;C. Jessica E. Metcalf;C. Jessica E. Metcalf;Rik L. de Swart;A. D. M. E. Osterhaus

  • Epigenetic Centromere Propagation and the Nature of CENP-A Nucleosomes

    Ben E. Black;Don W. Cleveland

  • HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore

    Meghan C. Barnhart;P. Henning J. L. Kuich;Madison E. Stellfox;Jared A. Ward

  • Calreticulin Is a receptor for nuclear export.

    James M. Holaska;Ben E. Black;Dona C. Love;John A. Hanover

  • PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

    Jennine M. Dawicki-McKenna;Marie-France Langelier;Jamie E. DeNizio;Amanda A. Riccio

  • Centromere Identity Maintained by Nucleosomes Assembled with Histone H3 Containing the CENP-A Targeting Domain

    Ben E. Black;Lars E.T. Jansen;Lars E.T. Jansen;Paul S. Maddox;Paul S. Maddox;Daniel R. Foltz;Daniel R. Foltz

  • The structure of (CENP-A–H4) 2 reveals physical features that mark centromeres

    Nikolina Sekulic;Emily A. Bassett;Danielle J. Rogers;Ben E. Black

  • The octamer is the major form of CENP-A nucleosomes at human centromeres

    Dan Hasson;Tanya Panchenko;Kevan J Salimian;Mishah U Salman

  • Structural basis for allosteric PARP-1 retention on DNA breaks.

    Levani Zandarashvili;Marie-France Langelier;Uday Kiran Velagapudi;Mark A. Hancock

  • CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere

    Samantha J. Falk;Lucie Y. Guo;Nikolina Sekulic;Evan M. Smoak

  • DNA binding domains in diverse nuclear receptors function as nuclear export signals.

    Ben E. Black;James M. Holaska;Fraydoon Rastinejad;Bryce M. Paschal

  • Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization.

    Daniel Gioeli;Ben E. Black;Vicki Gordon;Adam Spencer

  • The quantitative architecture of centromeric chromatin

    Dani L. Bodor;João F. Mata;Mikhail Sergeev;Mikhail Sergeev;Ana Filipa David

  • The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.

    Kara L. McKinley;Nikolina Sekulic;Lucie Y. Guo;Tonia Tsinman

  • Protein dynamics viewed by hydrogen exchange

    John J. Skinner;Woon K. Lim;Sabrina Bédard;Ben E. Black

  • Retrotranslocation of the Chaperone Calreticulin from the Endoplasmic Reticulum Lumen to the Cytosol

    Nima Afshar;Ben E. Black;Bryce M. Paschal

Frequent Co-Authors

Don W. Cleveland
Don W. Cleveland University of California, San Diego
Bryce M. Paschal
Bryce M. Paschal University of Virginia
Michael A. Lampson
Michael A. Lampson University of Pennsylvania
Jagesh V. Shah
Jagesh V. Shah Harvard University
Benjamin A. Garcia
Benjamin A. Garcia Washington University in St. Louis
S. Walter Englander
S. Walter Englander University of Pennsylvania
Karolin Luger
Karolin Luger University of Colorado Boulder
Donald F. Hunt
Donald F. Hunt University of Virginia
Jeffrey C. Hansen
Jeffrey C. Hansen Colorado State University

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