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Biology and Biochemistry

D-Index
61
Citations
12964
World Ranking
11377
National Ranking
4919

Overview

Bryce M. Paschal is affiliated with the University of Virginia in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a notable focus on Molecular Biology, Oncology, and Pulmonary and Respiratory Medicine. Additional subfields of study include Cancer Research and Epidemiology.

The main topics covered in their work center on PARP inhibition in cancer therapy, prostate cancer treatment and research, DNA repair mechanisms, nuclear structure and function, RNA research and splicing, ubiquitin and proteasome pathways, and autophagy in disease and therapy.

Paschal's recent papers include:

  • ADP-ribosyltransferases, an update on function and nomenclature (2021, FEBS Journal)
  • Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly (2021, Nature Communications)
  • Reconstitution of the DTX3L-PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly (2022, Biochemical Journal)
  • Post-Transcriptional Regulation of PARP7 Protein Stability Is Controlled by Androgen Signaling (2021, Cells)
  • PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus (2021, Biochemical Journal)

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Biochemical Journal, FEBS Journal, Nature Communications, and Cells.

Key frequent co-authors in their research include:

  • Chunsong Yang
  • Aakrosh Ratan
  • Krzysztof Wierbiłowicz
  • L. Lehtiö
  • Natalia M. Dworak

Best Publications

  • Mechanisms of receptor-mediated nuclear import and nuclear export.

    Lucy F. Pemberton;Bryce M. Paschal

  • Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis

    Christophe de Jesus Echeverri;Bryce Mark Paschal;Kevin T. Vaughan;Richard B. Vallee

  • MAP 1C is a microtubule-activated ATPase which translocates microtubules in vitro and has dynein-like properties.

    Bryce Mark Paschal;Howard S. Shpetner;Richard B. Vallee

  • Retrograde transport by the microtubule-associated protein MAP 1C

    Bryce Mark Paschal;Richard B. Vallee

  • Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor.

    Frauke Melchior;Bryce Paschal;Janice Evans;Larry Gerace

  • Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.

    Bryce M. Paschal;Larry Gerace

  • Microtubule-associated protein 1C from brain is a two-headed cytosolic dynein

    Richard B. Vallee;Joseph S. Wall;Bryce Mark Paschal;Howard S. Shpetner

  • Calreticulin Is a receptor for nuclear export.

    James M. Holaska;Ben E. Black;Dona C. Love;John A. Hanover

  • Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued

    Erika L. F. Holzbaur;James A. Hammarback;Bryce Mark Paschal;Nancy G. Kravit

  • DNA binding domains in diverse nuclear receptors function as nuclear export signals.

    Ben E. Black;James M. Holaska;Fraydoon Rastinejad;Bryce M. Paschal

  • Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization.

    Daniel Gioeli;Ben E. Black;Vicki Gordon;Adam Spencer

  • ADP-ribosyltransferases, an update on function and nomenclature

    Bernhard Lüscher;Ivan Ahel;Matthias Altmeyer;Alan Ashworth

  • Interaction of brain cytoplasmic dynein and MAP2 with a common sequence at the C terminus of tubulin.

    Bryce Mark Paschal;Bryce Mark Paschal;Robert A. Obar;Richard B. Vallee

  • FKBP51 Promotes Assembly of the Hsp90 Chaperone Complex and Regulates Androgen Receptor Signaling in Prostate Cancer Cells

    Li Ni;Chun-Song Yang;Daniel Gioeli;Henry Frierson

  • Retrotranslocation of the Chaperone Calreticulin from the Endoplasmic Reticulum Lumen to the Cytosol

    Nima Afshar;Ben E. Black;Bryce M. Paschal

  • Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9

    Chun-Song Yang;Kasey Jividen;Adam Spencer;Natalia Dworak

  • Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex.

    T Guan;S Müller;G Klier;N Panté

  • Ran-Binding Protein 3 Is a Cofactor for Crm1-Mediated Nuclear Protein Export

    Mark E. Lindsay;James M. Holaska;Katie Welch;Bryce M. Paschal

  • Characterization of the microtubule-activated ATPase of brain cytoplasmic dynein (MAP 1C).

    Howard S. Shpetner;Bryce Mark Paschal;Richard B. Vallee

  • Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin.

    Bryce Mark Paschal;Erika L. F. Holzbaur;K. Kevin Pfister;Sean W. Clark

Frequent Co-Authors

Richard B. Vallee
Richard B. Vallee Columbia University
Ben E. Black
Ben E. Black University of Pennsylvania
Larry Gerace
Larry Gerace Scripps Research Institute
Henry F. Frierson
Henry F. Frierson University of Virginia
David L. Brautigan
David L. Brautigan University of Virginia
Catherine Dargemont
Catherine Dargemont Université Paris Cité
David Rekosh
David Rekosh University of Virginia
Martin A. Schwartz
Martin A. Schwartz Yale University
Marie-Louise Hammarskjold
Marie-Louise Hammarskjold University of Virginia
William B. Dobyns
William B. Dobyns University of Minnesota

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