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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
93
Citations
29902
World Ranking
2119
National Ranking
47

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

David A. Jans is affiliated with Monash University in Australia and has contributed extensively to research in the fields of medicine, biochemistry, genetics and molecular biology, as well as immunology and microbiology. Their work spans multiple disciplines with a focus on molecular biology, infectious diseases, parasitology, public health, environmental and occupational health, and epidemiology.

The scientist's research primarily addresses topics such as mosquito-borne diseases and control, nuclear structure and function, parasites and host interactions, parasitic diseases research and treatment, RNA research and splicing, viral infections and vectors, and respiratory viral infections research.

Recent publications include the following papers:

  • The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, 2020, Antiviral Research
  • The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer, 2020, Antiviral Research
  • Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses, 2020, Antiviral Research
  • Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?, 2020, Cells
  • Impact of Respiratory Syncytial Virus Infection on Host Functions: Implications for Antiviral Strategies, 2020, Physiological Reviews

Frequent coauthors include:

  • Kylie M. Wagstaff (21 collaborations)
  • Marie A. Bogoyevitch (6 collaborations)
  • Sujata B. Walunj (5 collaborations)
  • Swati Patankar (5 collaborations)
  • Gregory W. Moseley (5 collaborations)

David A. Jans's work is published often in venues such as:

  • Cells (9 publications)
  • Nature Communications (4 publications)
  • Antiviral Research (3 publications)
  • International Journal of Molecular Sciences (3 publications)
  • Biochemical and Biophysical Research Communications (2 publications)

Best Publications

  • The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro.

    Leon Caly;Julian D. Druce;Mike G. Catton;David A. Jans

  • Towards safe, non-viral therapeutic gene expression in humans

    Dominic J Glover;Hans J Lipps;David Andrew Jans;David Andrew Jans

  • Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus.

    Kylie M. Wagstaff;Haran Sivakumaran;Steven M. Heaton;David Harrich

  • Nuclear targeting signal recognition: a key control point in nuclear transport?

    David A. Jans;Chong Yun Xiao;Mark H C Lam

  • Regulation of protein transport to the nucleus: Central role of phosphorylation

    David A. Jans;Stefan Hübner

  • The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen.

    Hans Peter Rihs;David A. Jans;Hua Fan;Reiner Peters

  • Regulation of Nuclear Transport: Central Role in Development and Transformation?

    Ivan K H Poon;David Andrew Jans;David Andrew Jans

  • An efficient system for high-level expression and easy purification of authentic recombinant proteins.

    Ann-Maree Catanzariti;Tatiana A. Soboleva;David A. Jans;David A. Jans;Philip G. Board

  • Nuclear Import of Insulin-like Growth Factor-binding Protein-3 and -5 Is Mediated by the Importin β Subunit

    Lynette J. Schedlich;Sophie L. Le Page;Sue M. Firth;Lyndall J. Briggs

  • Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.

    M Y F Tay;Johanna Elisabeth Fraser;W K K Chan;Nicole J Moreland

  • The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

    Sundy N.Y. Yang;Sarah C. Atkinson;Chunxiao Wang;Alexander Lee

  • The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large T-antigen nuclear localization sequence by importin.

    Stefan Hübner;Chong Yun Xiao;David A. Jans

  • Targeted delivery to the nucleus.

    Colin William Pouton;Kylie Michelle Wagstaff;Daniela Martino Roth;Daniela Martino Roth;Gregory William Moseley

  • p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins.

    David A. Jans;Matthias J. Ackermann;James R. Bischoff;David H. Beach

  • The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65

    Hayley J Newton;Jaclyn S Pearson;Luminita Badea;Michelle Kelly

  • Cytosolic delivery of granzyme B by bacterial toxins: Evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

    Kylie A. Browne;Elizabeth Blink;Vivien R. Sutton;Christopher J. Froelich

  • Targeted intracellular delivery of photosensitizers to enhance photodynamic efficiency.

    Andrey A Rosenkranz;David A Jans;Alexander S Sobolev;Alexander S Sobolev

  • Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha.

    Mark H.C. Lam;Lyndall J. Briggs;Wei Hu;T. John Martin

  • The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties.

    Athina Efthymiadis;Lyndall J. Briggs;David A. Jans

  • Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha.

    Marcos R. M. Fontes;Marcos R. M. Fontes;Trazel Teh;Trazel Teh;David A. Jans;David A. Jans;Ross I. Brinkworth

Frequent Co-Authors

Kate L Loveland
Kate L Loveland Hudson Institute of Medical Research
Marie A. Bogoyevitch
Marie A. Bogoyevitch University of Melbourne
Joseph A. Trapani
Joseph A. Trapani Peter MacCallum Cancer Centre
Falk Fahrenholz
Falk Fahrenholz Johannes Gutenberg University of Mainz
Brian A. Hemmings
Brian A. Hemmings Friedrich Miescher Institute
Subhash G. Vasudevan
Subhash G. Vasudevan Australian National University
Graeme B. Cox
Graeme B. Cox Australian National University
Frank Gibson
Frank Gibson Australian National University
Colin W. Pouton
Colin W. Pouton Monash University
Bostjan Kobe
Bostjan Kobe University of Queensland

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