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Microbiology

D-Index
76
Citations
16567
World Ranking
1457
National Ranking
44

Overview

Subhash G. Vasudevan is affiliated with the Duke NUS Graduate Medical School in Singapore. Their research is primarily situated within the field of medicine, with a specific focus on public health, environmental and occupational health, infectious diseases, insect science, epidemiology, and virology. Their work covers a broad range of topics related to mosquito-borne diseases and control, viral infections and vectors, insect symbiosis and bacterial influences, malaria research and control, HIV research and treatment, viral infections and outbreaks research, as well as virology and viral diseases.

Recent publications by Subhash G. Vasudevan include:

  • Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase, 2020, Journal of Virology
  • Therapeutics for flaviviral infections, 2022, Antiviral Research
  • Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase, 2020, ACS Medicinal Chemistry Letters
  • Dysregulated metabolism underpins Zika-virus-infection-associated impairment in fetal development, 2021, Cell Reports
  • A Non-structural 1 Protein G53D Substitution Attenuates a Clinically Tested Live Dengue Vaccine, 2020, Cell Reports

They have collaborated frequently with a number of researchers including Kitti Wing Ki Chan, Satoru Watanabe, Milly M. Choy, Eng Eong Ooi, and Dahai Luo. These collaborative efforts seem to span multiple projects contributing to a variety of scientific outputs.

The venues in which Subhash G. Vasudevan has published frequently include:

  • Antiviral Research
  • European Journal of Medicinal Chemistry
  • ACS Infectious Diseases
  • EBioMedicine
  • Journal of Virology

Their research topics emphasize the interface of viral infections with vector biology and disease control strategies, often exploring the molecular and biochemical mechanisms involved in viral replication and infection. This includes work on antiviral compounds targeting RNA-dependent RNA polymerases and investigations of viral protein modifications affecting vaccine efficacy.

Best Publications

  • Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

    Paul Erbel;Nikolaus Schiering;Allan D'Arcy;Martin Renatus

  • Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

    Thai Leong Yap;Ting Xu;Yen-Liang Chen;Helene Malet

  • Crystal structure of the NS3 protease-helicase from dengue virus

    Dahai Luo;Ting Xu;Cornelia Hunke;Gerhard Grüber

  • Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.

    M Y F Tay;Johanna Elisabeth Fraser;W K K Chan;Nicole J Moreland

  • A Dengue Fever Viremia Model in Mice Shows Reduction in Viral Replication and Suppression of the Inflammatory Response after Treatment with Antiviral Drugs

    Wouter Schul;Wei Liu;Hao-Ying Xu;Marie Flamand

  • Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness.

    Lukas B. Tanner;Mark Schreiber;Jenny G. H. Low;Adrian Ong

  • The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development.

    Dahai Luo;Subhash G. Vasudevan;Julien Lescar;Julien Lescar

  • Cholesterol biosynthesis modulation regulates dengue viral replication.

    Christopher Rothwell;Aude LeBreton;Chuan Young Ng;Joanne Y.H. Lim

  • Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein

    Dahai Luo;Ting Xu;Randall P Watson;Daniella Scherer-Becker

  • Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

    Jun Li;Siew Pheng Lim;David Beer;Viral Patel

  • Host Gene Expression Profiling of Dengue Virus Infection in Cell Lines and Patients

    Joshua Fink;Feng Gu;Ling Ling;Thomas Tolfvenstam

  • Update on Dengue: Epidemiology, Virus Evolution, Antiviral Drugs, and Vaccine Development

    Annelies Wilder-Smith;Eng Eong Ooi;Subhash G. Vasudevan;Duane J. Gubler

  • Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

    Julien Lescar;Dahai Luo;Ting Xu;Aruna Sampath

  • Structure of the Dengue Virus Helicase/Nucleoside Triphosphatase Catalytic Domain at a Resolution of 2.4 Å

    Ting Xu;Aruna Sampath;Alex Chao;Daying Wen

  • Isolation and nucleotide sequence of the hmp gene that encodes a haemoglobin-like protein in Escherichia coli K-12.

    Vasudevan Sg;Armarego Wl;Shaw Dc;Lilley Pe

  • Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA

    Indira Umareddy;Alex Chao;Aruna Sampath;Feng Gu

  • Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial.

    Jenny G Low;Cynthia Sung;Limin Wijaya;Yuan Wei

  • Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance

    Ashley L. St. John;Abhay P. S. Rathore;Han Yap;Mah-Lee Ng

  • A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

    Yongqian Zhao;Tingjin Sherryl Soh;Jie Zheng;Kitti Wing Ki Chan

  • A Small-Molecule Dengue Virus Entry Inhibitor

    Qing-Yin Wang;Sejal J. Patel;Eric Vangrevelinghe;Hao Ying Xu

  • Dengue and dengue hemorrhagic fever.

    D. J. Gubler;E. E. Ooi;S. Vasudevan;J. Farrar

Frequent Co-Authors

Julien Lescar
Julien Lescar Nanyang Technological University
Eng Eong Ooi
Eng Eong Ooi National University of Singapore
Duane J. Gubler
Duane J. Gubler Duke NUS Graduate Medical School
Siew Pheng Lim
Siew Pheng Lim A*STAR - Agency for Science, Technology and Research
David L. Ollis
David L. Ollis Australian National University
Jeremy Farrar
Jeremy Farrar World Health Organization
David A. Jans
David A. Jans Monash University
Martin L. Hibberd
Martin L. Hibberd London School of Hygiene & Tropical Medicine
Thomas H. Keller
Thomas H. Keller Novartis (Switzerland)
Nicholas E. Dixon
Nicholas E. Dixon University of Wollongong

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