D-Index & Metrics Best Publications

Siew Pheng Lim

A*STAR - Agency for Science, Technology and Research
Singapore

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name Citations Publications World Ranking National Ranking

Biology and Biochemistry D-index 44 Citations 6,382 80 World Ranking 16376 National Ranking 63

Overview

What is he best known for?

The fields of study he is best known for:

Gene
DNA
Enzyme

Siew Pheng Lim mostly deals with Dengue virus, NS3, Virology, Flavivirus and Dengue fever. Viral protein is closely connected to Biochemistry in his research, which is encompassed under the umbrella topic of Dengue virus. The NS3 study which covers RNA that intersects with Hepatitis C virus and Guanylyltransferase.

In Virology, he works on issues like Drug discovery, which are connected to RNA polymerase, Balapiravir, Nucleoside analogue and Clinical trial. Flavivirus is often connected to Binding site in his work. Siew Pheng Lim combines subjects such as Proteases and Tetrapeptide with his study of Protease.

His most cited work include:

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. (375 citations)
Ten years of dengue drug discovery: Progress and prospects (233 citations)
Strategies for development of Dengue virus inhibitors. (203 citations)

What are the main themes of his work throughout his whole career to date?

Siew Pheng Lim mainly investigates Dengue virus, Virology, Flavivirus, Molecular biology and Biochemistry. His study in Dengue virus is interdisciplinary in nature, drawing from both RNA, Polymerase, RNA-dependent RNA polymerase, Methyltransferase and Drug discovery. His studies in Viral replication, Virus, Dengue fever, NS3 and Hepatitis C virus are all subfields of Virology research.

His work in the fields of Dengue fever, such as Balapiravir, intersects with other areas such as Drug development. The various areas that Siew Pheng Lim examines in his Flavivirus study include Virtual screening and Viral protein. His Molecular biology study incorporates themes from Messenger RNA, Transfection, Expression vector and Major histocompatibility complex.

He most often published in these fields:

Dengue virus (55.13%)
Virology (44.87%)
Flavivirus (30.77%)

What were the highlights of his more recent work (between 2014-2021)?

Dengue virus (55.13%)
Polymerase (21.79%)
Virology (44.87%)

In recent papers he was focusing on the following fields of study:

Siew Pheng Lim mainly focuses on Dengue virus, Polymerase, Virology, Flavivirus and RNA-dependent RNA polymerase. He has researched Dengue virus in several fields, including Hepatitis C virus, RNA, RNA polymerase, Phosphoramidate and Viral replication. His Polymerase study is concerned with the field of Biochemistry as a whole.

His research combines Genetics and Virology. His studies in Flavivirus integrate themes in fields like Drug discovery and Dengue fever. His Drug discovery research includes elements of NS3 and Guanylyltransferase.

Between 2014 and 2021, his most popular works were:

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication (152 citations)
The dengue virus NS5 protein as a target for drug discovery (101 citations)
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling (61 citations)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

Paul Erbel;Nikolaus Schiering;Allan D'Arcy;Martin Renatus.
Nature Structural & Molecular Biology (2006)

550 Citations

Ten years of dengue drug discovery: Progress and prospects

Siew Pheng Lim;Qing Yin Wang;Christian G. Noble;Yen Liang Chen.
Antiviral Research (2013)

346 Citations

Strategies for development of Dengue virus inhibitors.

Christian G. Noble;Yen Liang Chen;Hongping Dong;Feng Gu.
Antiviral Research (2010)

300 Citations

Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

Jun Li;Siew Pheng Lim;David Beer;Viral Patel.
Journal of Biological Chemistry (2005)

268 Citations

Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein

Dahai Luo;Ting Xu;Randall P Watson;Daniella Scherer-Becker.
The EMBO Journal (2008)

255 Citations

Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

Julien Lescar;Dahai Luo;Ting Xu;Aruna Sampath.
Antiviral Research (2008)

246 Citations

Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead.

Zheng Yin;Sejal J. Patel;Wei-Ling Wang;Gang Wang.
Bioorganic & Medicinal Chemistry Letters (2006)

195 Citations

Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.

Wan Theng Sing;Cheng Leng Lee;Su Ling Yeo;Siew Pheng Lim.
Bioorganic & Medicinal Chemistry Letters (2001)

194 Citations

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

Yongqian Zhao;Tingjin Sherryl Soh;Jie Zheng;Kitti Wing Ki Chan.
PLOS Pathogens (2015)

186 Citations

Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.

Zheng Yin;Sejal J. Patel;Wei-Ling Wang;Wai-Ling Chan.
Bioorganic & Medicinal Chemistry Letters (2006)

171 Citations

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Frequent Co-Authors

External Links

Personal Website for Siew Pheng Lim