2026 Siew Pheng Lim: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	49	18088	16601	66	65	93	7776

Overview

Siew Pheng Lim is affiliated with the A*STAR - Agency for Science, Technology and Research in Singapore. Their research primarily focuses on medicine, with a particular emphasis on infectious diseases.

The main fields of study covered by their work include:

Medicine

Their subfields of study reflect a focus on:

Infectious Diseases
Public Health, Environmental and Occupational Health
Virology
Neurology
Computational Theory and Mathematics

The main research topics addressed in their publications comprise:

Mosquito-borne diseases and control
SARS-CoV-2 and COVID-19 Research
Viral Infections and Vectors
Malaria Research and Control
HIV Research and Treatment
HIV/AIDS drug development and treatment
COVID-19 Clinical Research Studies

Frequent co-authors collaborating with Siew Pheng Lim include:

Fumiaki Yokokawa
Cheah C. Seh
Yen-Liang Chen
Pei-Yong Shi
Ratna Karuna

Common venues for their research publications are:

Science Translational Medicine
Antimicrobial Agents and Chemotherapy
Journal of Virology
Antiviral Research
ChemMedChem

Selected recent papers include:

"NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models" (2021), published in Science Translational Medicine
"A Cyclic Phosphoramidate Prodrug of 2'-Deoxy-2'-Fluoro-2'- C -Methylguanosine for the Treatment of Dengue Virus Infection" (2020), published in Antimicrobial Agents and Chemotherapy
"Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies" (2020), published in Journal of Virology
"Targeting SARS-CoV-2 and host cell receptor interactions" (2022), published in Antiviral Research
"A Patent Review on SARS Coronavirus Papain-Like Protease (PL^pro) Inhibitors" (2023), published in ChemMedChem

Best Publications

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

Paul Erbel;Nikolaus Schiering;Allan D'Arcy;Martin Renatus

661
Citations
Ten years of dengue drug discovery: Progress and prospects

Siew Pheng Lim;Qing Yin Wang;Christian G. Noble;Yen Liang Chen

398
Citations
Strategies for development of Dengue virus inhibitors.

Christian G. Noble;Yen Liang Chen;Hongping Dong;Feng Gu

319
Citations
Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein

Dahai Luo;Ting Xu;Randall P Watson;Daniella Scherer-Becker

301
Citations
Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

Jun Li;Siew Pheng Lim;David Beer;Viral Patel

291
Citations
Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

Julien Lescar;Dahai Luo;Ting Xu;Aruna Sampath

270
Citations
A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

Yongqian Zhao;Tingjin Sherryl Soh;Jie Zheng;Kitti Wing Ki Chan

245
Citations
The dengue virus NS5 protein as a target for drug discovery

Siew Pheng Lim;Christian G. Noble;Pei-Yong Shi

219
Citations
Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead.

Zheng Yin;Sejal J. Patel;Wei-Ling Wang;Gang Wang

205
Citations
Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.

Wan Theng Sing;Cheng Leng Lee;Su Ling Yeo;Siew Pheng Lim

204
Citations
Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

Siew Pheng Lim;Louis Sebastian Sonntag;Christian Noble;Shahul H. Nilar

201
Citations
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.

Zheng Yin;Sejal J. Patel;Wei-Ling Wang;Wai-Ling Chan

180
Citations
2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase.

Hongping Dong;Hongping Dong;David C. Chang;Maggie Ho Chia Hua;Siew Pheng Lim

155
Citations
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Siew Pheng Lim;Christian Guy Noble;Cheah Chen Seh;Tingjin Sherryl Soh;Tingjin Sherryl Soh

154
Citations
Cellular RNA Helicase p68 Relocalization and Interaction with the Hepatitis C Virus (HCV) NS5B Protein and the Potential Role of p68 in HCV RNA Replication

Phuay Yee Goh;Yee Joo Tan;Siew Pheng Lim;Y. H. Tan

153
Citations
The Human Immunodeficiency Virus Type 1 Tat Protein Up-Regulates the Promoter Activity of the Beta-Chemokine Monocyte Chemoattractant Protein 1 in the Human Astrocytoma Cell Line U-87 MG: Role of SP-1, AP-1, and NF-κB Consensus Sites

Siew Pheng Lim;Alfredo Garzino-Demo

136
Citations
Flavivirus RNA methylation

Hongping Dong;Katja Fink;Roland Züst;Siew Pheng Lim

133
Citations
Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

Christian G. Noble;Siew Pheng Lim;Yen Liang Chen;Chong Wai Liew

130
Citations
Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput Docking

Dariusz Ekonomiuk;Xun-Cheng Su;Kiyoshi Ozawa;Christophe Bodenreider

124
Citations
Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing.

Chuan Young Ng;Feng Gu;Wai Yee Phong;Yen-Liang Chen

116
Citations