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Chemistry

D-Index
43
Citations
7241
World Ranking
17182
National Ranking
286

Overview

Thomas H. Keller is affiliated with Novartis in Switzerland. Their research spans several interconnected fields including Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad areas, Keller has focused extensively on Molecular Biology, Physiology, Neurology, Cell Biology, and Radiology, Nuclear Medicine and Imaging as subfields of study.

The scientist's work covers a range of significant topics, prominently featuring Protein Degradation and Inhibitors, Neuroinflammation and Neurodegeneration Mechanisms, Click Chemistry and Applications, Protein Tyrosine Phosphatases, PI3K/AKT/mTOR signaling in cancer, Microtubule and mitosis dynamics, and Alzheimer's disease research and treatments.

Notable publication venues for Keller include:

  • Molecular Imaging and Biology
  • EJNMMI Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nuclear Medicine and Biology
  • Angewandte Chemie International Edition

Keller has contributed to multiple research papers, among them:

  • Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors, 2021, Angewandte Chemie International Edition
  • Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury via interleukin-1 receptor antagonist, 2020, Theranostics
  • Structural model of human PORCN illuminates disease-associated variants and drug-binding sites, 2021, Journal of Cell Science
  • Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe, 2021, The Journal of Experimental Medicine
  • Plasma cell-free DNA predicts pediatric cerebral malaria severity, 2020, JCI Insight

Frequent collaborators in Keller's research include:

  • Olof Solin
  • Nithya Baburajendran
  • Joma Joy
  • Merja Haaparanta-Solin
  • Tove J. Grönroos

This collaborative network and choice of publication venues indicate engagement with both clinical and molecular aspects of biomedical research. Keller's contributions integrate experimental approaches in molecular biology with translational applications relevant to disease mechanisms and therapeutic strategies.

Best Publications

  • PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

    Ramandeep Singh;Ujjini Manjunatha;Ujjini Manjunatha;Helena I. M. Boshoff;Young Hwan Ha

  • Spirotetrahydro β-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

    Bryan K S Yeung;Bin Zou;Matthias Rottmann;Suresh B Lakshminarayana

  • A practical view of 'druggability'

    Thomas H Keller;Arkadius Pichota;Zheng Yin

  • A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

    Kevin Pethe;Patricia C. Sequeira;Sanjay Agarwalla;Kyu Rhee

  • A Small-Molecule Dengue Virus Entry Inhibitor

    Qing-Yin Wang;Sejal J. Patel;Eric Vangrevelinghe;Hao Ying Xu

  • Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead.

    Zheng Yin;Sejal J. Patel;Wei-Ling Wang;Gang Wang

  • Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

    Siew Pheng Lim;Louis Sebastian Sonntag;Christian Noble;Shahul H. Nilar

  • Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.

    Zheng Yin;Sejal J. Patel;Wei-Ling Wang;Wai-Ling Chan

  • Inhibitors of phosphatidylinositol 3-kinase

    Ian Bruce;Bernard Cuenoud;Thomas Hugo Keller;Gaynor Elizabeth Pilgrim

  • Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles

    Pilho Kim;Liang Zhang;Ujjini H. Manjunatha;Ramandeep Singh

  • A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.

    Christophe Bodenreider;David Beer;Thomas H. Keller;Sebastian Sonntag

  • NMR analysis of a novel enzymatically-active unlinked Dengue NS2B-NS3 protease complex

    Young Mee Kim;Shovanlal Gayen;CongBao Kang;Joma Joy

  • The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist

    François Baur;David Beattie;David Beer;David Bentley

  • Imidazolopiperazines: hit to lead optimization of new antimalarial agents.

    Tao Wu;Advait Nagle;Kelli Kuhen;Kerstin Gagaring

  • Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis

    Mekonnen Kurabachew;Stephen H. J. Lu;Philipp Krastel;Esther K. Schmitt

  • Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors

    Yan Li;Zhenzhen Zhang;Wint Wint Phoo;Ying Ru Loh

  • Global bayesian models for the prioritization of antitubercular agents.

    Philip Prathipati;Ngai Ling Ma;Thomas H. Keller

  • Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.

    Pilho Kim;Sunhee Kang;Helena I. Boshoff;Jan Jiricek

  • Peptide Inhibitors of West Nile NS3 Protease: SAR Study of Tetrapeptide Aldehyde Inhibitors

    John E Knox;Ngai Ling Ma;Zheng Yin;Sejal J Patel

  • Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor

    Yan Li;Zhenzhen Zhang;Wint Wint Phoo;Ying Ru Loh

  • Diastereocontrolled nickel(0)- and palladium(0) catalyzed “metallo-ene-type” cyclizations/carbonylations

    Wolfgang Oppolzer;Thomas H. Keller;Manuel Bedoya-Zurita;Charles Stone

Frequent Co-Authors

Yan Li
Yan Li Sun Yat-sen University
Subhash G. Vasudevan
Subhash G. Vasudevan Australian National University
David M. Virshup
David M. Virshup Duke NUS Graduate Medical School
Pei-Yong Shi
Pei-Yong Shi GlaxoSmithKline (United Kingdom)
Siew Pheng Lim
Siew Pheng Lim A*STAR - Agency for Science, Technology and Research
Véronique Dartois
Véronique Dartois Rutgers, The State University of New Jersey
Thomas Dick
Thomas Dick Georgetown University
Reto Brun
Reto Brun University of Basel
Ian N. Bruce
Ian N. Bruce University of Manchester
Elizabeth A. Winzeler
Elizabeth A. Winzeler University of California, San Diego

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