World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
68
Citations
15280
World Ranking
2179
National Ranking
9

Overview

Julien Lescar is affiliated with Nanyang Technological University in Singapore. Their research focuses primarily on Medicine and Biochemistry, Genetics and Molecular Biology, with substantial contributions to Molecular Biology and Infectious Diseases. Additional areas of study include Public Health, Environmental and Occupational Health, Oncology, and Radiology, Nuclear Medicine and Imaging.

Their main topics of work encompass biochemical and structural characterization, research on SARS-CoV-2 and COVID-19, malaria research and control, peptidase inhibition and analysis, monoclonal and polyclonal antibodies research, mosquito-borne diseases and control, as well as chemical synthesis and analysis.

Lescar's recent papers include the following:

  • SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets, 2021, eLife
  • PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function, 2020, Nature Chemical Biology
  • Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells, 2021, Nature Microbiology
  • Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase, 2020, Journal of Virology
  • Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth, 2022, Nature Communications

They frequently collaborate with Abbas El Sahili, James P. Tam, Chuan-Fa Liu, Side Hu, and Yee Hwa Wong.

Lescar's publications have appeared in several scientific venues, notably bioRxiv (Cold Spring Harbor Laboratory), Journal of the American Chemical Society, Methods in Molecular Biology, Nature Communications, and Journal of Structural Biology.

Best Publications

  • Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation

    Stéphane Bressanelli;Karin Stiasny;Steven L Allison;Enrico A Stura

  • The Fusion Glycoprotein Shell of Semliki Forest Virus: An Icosahedral Assembly Primed for Fusogenic Activation at Endosomal pH

    Julien Lescar;Julien Lescar;Alain Roussel;Michelle W. Wien;Jorge Navaza

  • Conventional and unconventional mechanisms for capping viral mRNA

    Etienne Decroly;François Ferron;Julien Lescar;Julien Lescar;Bruno Canard

  • Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

    Thai Leong Yap;Ting Xu;Yen-Liang Chen;Helene Malet

  • Ten years of dengue drug discovery: Progress and prospects

    Siew Pheng Lim;Qing Yin Wang;Christian G. Noble;Yen Liang Chen

  • Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

    Etienne Decroly;Claire Debarnot;François Ferron;Mickael Bouvet

  • Crystal structure of the NS3 protease-helicase from dengue virus

    Dahai Luo;Ting Xu;Cornelia Hunke;Gerhard Grüber

  • The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development.

    Dahai Luo;Subhash G. Vasudevan;Julien Lescar;Julien Lescar

  • Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein

    Dahai Luo;Ting Xu;Randall P Watson;Daniella Scherer-Becker

  • The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

    Hélène Malet;Bruno Coutard;Saïd Jamal;Hélène Dutartre

  • Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

    Julien Lescar;Dahai Luo;Ting Xu;Aruna Sampath

  • Structure of the Dengue Virus Helicase/Nucleoside Triphosphatase Catalytic Domain at a Resolution of 2.4 Å

    Ting Xu;Aruna Sampath;Alex Chao;Daying Wen

  • Structure of the Functional Form of the Mosquito Larvicidal Cry4Aa Toxin from Bacillus thuringiensis at a 2.8-Angstrom Resolution

    Panadda Boonserm;Min Mo;Chanan Angsuthanasombat;Julien Lescar

  • Structure of the NS2B-NS3 protease from Zika virus after self-cleavage.

    Wint Wint Phoo;Yan Li;Zhenzhen Zhang;Michelle Yueqi Lee

  • A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

    Yongqian Zhao;Tingjin Sherryl Soh;Jie Zheng;Kitti Wing Ki Chan

  • Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein.

    J. J. H. Chu;R. Rajamanonmani;J. Li;R. Bhuvanakantham

  • The flavivirus polymerase as a target for drug discovery

    Hélène Malet;Nicolas Massé;Barbara Selisko;Jean-Louis Romette

  • Engineering a Catalytically Efficient Recombinant Protein Ligase

    Renliang Yang;Yee Hwa Wong;Giang K T Nguyen;James P Tam

  • Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

    Siew Pheng Lim;Louis Sebastian Sonntag;Christian Noble;Shahul H. Nilar

  • The N-terminal domain of the Arenavirus L protein is an RNA endonuclease essential in mRNA transcription

    Benjamin Morin;Bruno Coutard;Michaela Lelke;François Ferron

  • Biochemical and structural analysis of Helix pomatia agglutinin. A hexameric lectin with a novel fold.

    Jean-Frederic Sanchez;Julien Lescar;Julien Lescar;Valérie Chazalet;Aymeric Audfray

  • An unusual carbohydrate binding site revealed by the structures of two Maackia amurensis lectins complexed with sialic acid-containing oligosaccharides.

    Anne Imberty;Catherine Gautier;Julien Lescar;Julien Lescar;Serge Pérez

Frequent Co-Authors

Subhash G. Vasudevan
Subhash G. Vasudevan Australian National University
Pei-Yong Shi
Pei-Yong Shi GlaxoSmithKline (United Kingdom)
Siew Pheng Lim
Siew Pheng Lim A*STAR - Agency for Science, Technology and Research
James P. Tam
James P. Tam Nanyang Technological University
Eng Eong Ooi
Eng Eong Ooi National University of Singapore
Chandra S. Verma
Chandra S. Verma Agency for Science, Technology and Research
Bruno Canard
Bruno Canard Aix-Marseille University
Scott A. Rice
Scott A. Rice Nanyang Technological University

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