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Biology and Biochemistry
Singapore
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
102
Citations
33474
World Ranking
1387
National Ranking
5

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Singapore Leader Award
  • 2025 - Research.com Biology and Biochemistry in Singapore Leader Award
  • 2023 - Research.com Biology and Biochemistry in Singapore Leader Award
  • 2022 - Research.com Biology and Biochemistry in Singapore Leader Award

Overview

James P. Tam is affiliated with Nanyang Technological University in Singapore. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions to Medicine. Key subfields of study include Molecular Biology, Oncology, Biotechnology, Pharmacology, and Microbiology.

The scientist's research topics cover a range of biochemical and molecular aspects such as biochemical and structural characterization, glycosylation and glycoproteins research, peptidase inhibition and analysis, chemical synthesis and analysis, antimicrobial peptides and activities, enzyme production and characterization, and natural product bioactivities and synthesis.

Recent publications provide insights into their research focus:

  • Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: Integration of herbal medicine, enzyme engineering, and nanotechnology (2022, Journal of Pharmaceutical Analysis)
  • pH-Controlled Protein Orthogonal Ligation Using Asparaginyl Peptide Ligases (2021, Journal of the American Chemical Society)
  • Turning an Asparaginyl Endopeptidase into a Peptide Ligase (2020, ACS Catalysis)
  • Construction of Fe3O4@α-glucosidase magnetic nanoparticles for ligand fishing of α-glucosidase inhibitors from a natural tonic Epimedii Folium (2020, International Journal of Biological Macromolecules)
  • Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity (2020, Chemical Communications)

Frequent collaborators in their work include Chuan-Fa Liu, Shining Loo, Antony Kam, Julien Lescar, and Side Hu.

The scientist's work has appeared frequently in various publication venues. Notable ones include bioRxiv (Cold Spring Harbor Laboratory), Angewandte Chemie International Edition, Angewandte Chemie, CHEST Journal, and the Journal of the American Chemical Society.

In addition to articles, James P. Tam has contributed to book publications, including a title published by Springer Science+Business Media:

  • Chemical Protein Synthesis (2022)

Best Publications

  • Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system

    James P. Tam

  • Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction.

    Virender K. Sarin;Stephen B.H. Kent;James P. Tam;R.B. Merrifield

  • An STS-Based Map of the Human Genome

    Thomas J. Hudson;Lincoln D. Stein;Sebastian S. Gerety;Junli Ma

  • An SN2 deprotection of synthetic peptides with a low concentration of hydrofluoric acid in dimethyl sulfide: evidence and application in peptide synthesis

    James P. Tam;William F. Heath;R. B. Merrifield

  • Disulfide bond formation in peptides by dimethyl sulfoxide. Scope and applications

    James P. Tam;Cui Rong Wu;Wen Liu;Jing Wen Zhang

  • An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides

    James P. Tam;Yi-An Lu;Jin-Long Yang;Kou-Wei Chiu

  • Human Coronaviruses: A Review of Virus-Host Interactions.

    Yvonne Xinyi Lim;Yan Ling Ng;James Pingkwan Tam;Ding Xiang Liu

  • Unprotected Peptides as Building Blocks for the Synthesis of Peptide Dendrimers with Oxime, Hydrazone, and Thiazolidine Linkages

    Jun Shao;James P. Tam

  • Peptide dendrimers: applications and synthesis.

    Kristen Sadler;James P. Tam

  • A novel method for producing anti-peptide antibodies. Production of site-specific antibodies to the T cell antigen receptor beta-chain.

    D N Posnett;H McGrath;J P Tam

  • Antimicrobial Peptides from Plants

    James Pingkwan Tam;Shujing Wang;Ka Ho Wong;Wei Liang Tan

  • Rationale for Development of a Synthetic Vaccine Against Plasmodium falciparum Malaria

    Fidel Zavala;James P. Tam;Michael R. Hollingdale;Allan H. Cochrane

  • Expression of transforming growth factor α and its messenger ribonucleic acid in human breast cancer: its regulation by estrogen and its possible functional significance

    Susan E. Bates;Nancy E. Davidson;Eva M. Valverius;Carl E. Freter

  • Multiple antigen peptide system

    James P. Tam

  • Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis

    Giang Kien Truc Nguyen;Shujing Wang;Yibo Qiu;Xinya Hemu

  • Peptide synthesis using unprotected peptides through orthogonal coupling methods.

    James P. Tam;Yi-An Lu;Chuan-Fa Liu;Jun Shao

  • Lipid rafts are involved in SARS-CoV entry into Vero E6 cells.

    Yanning Lu;Ding Xiang Liu;Ding Xiang Liu;James P. Tam;James P. Tam

  • Antimicrobial dendrimeric peptides.

    James P. Tam;Yi‐An Lu;Jin‐Long Yang

  • Circumsporozoite protein of Plasmodium vivax: gene cloning and characterization of the immunodominant epitope

    David E. Arnot;John W. Barnwell;James P. Tam;Victor Nussenzweig

  • Peptide segment ligation strategy without use of protecting groups.

    Chuan-Fa Liu;James P. Tam

Frequent Co-Authors

R. B. Merrifield
R. B. Merrifield Rockefeller University
Siu Kwan Sze
Siu Kwan Sze Nanyang Technological University
Kristoffer Almdal
Kristoffer Almdal Technical University of Denmark
Julien Lescar
Julien Lescar Nanyang Technological University
Fidel P Zavala
Fidel P Zavala Johns Hopkins University
Daniel H. Rich
Daniel H. Rich University of Wisconsin–Madison
Ruth S. Nussenzweig
Ruth S. Nussenzweig New York University
Sai Kiang Lim
Sai Kiang Lim Agency for Science, Technology and Research
Richard D. DiMarchi
Richard D. DiMarchi Indiana University
Victor Nussenzweig
Victor Nussenzweig New York University

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