World's Best Scientists 2026 revealed!
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Chemistry
Australia
2025
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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Chemistry

D-Index
79
Citations
17148
World Ranking
3709
National Ranking
95

Biology and Biochemistry

D-Index
82
Citations
18111
World Ranking
3772
National Ranking
89

Research.com Recognitions

  • 2025 - Research.com Chemistry in Australia Leader Award
  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award
  • 2022 - Research.com Chemistry in Australia Leader Award

Overview

Norelle L. Daly is affiliated with James Cook University in Australia. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with significant contributions to related subfields including molecular biology, immunology, genetics, microbiology, and public health, environmental, and occupational health.

The primary areas of focus in their work involve detailed studies on nicotinic acetylcholine receptors, ion channel regulation and function, and antimicrobial peptides and activities. Additional topics of research include venomous animal envenomation and studies, receptor mechanisms and signaling, biochemical and structural characterization, as well as chemical synthesis and analysis.

Their frequently publishing venues reflect a diverse engagement with the scientific community and include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Immunology
  • Biomedicines
  • Marine Drugs
  • Journal of Natural Products

Several recent papers highlight their contributions to various scientific subfields. These include:

  • The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation, 2020, Nature Immunology
  • Revisiting Inflammatory Bowel Disease: Pathology, Treatments, Challenges and Emerging Therapeutics Including Drug Leads from Natural Products, 2020, Journal of Clinical Medicine
  • ampir: an R package for fast genome-wide prediction of antimicrobial peptides, 2020, Bioinformatics
  • Gastrointestinal Helminth Infection Improves Insulin Sensitivity, Decreases Systemic Inflammation, and Alters the Composition of Gut Microbiota in Distinct Mouse Models of Type 2 Diabetes, 2021, Frontiers in Endocrinology
  • ApInAPDB: a database of apoptosis-inducing anticancer peptides, 2022, Scientific Reports

Their frequent collaborators include several researchers with whom they have co-authored multiple publications. These peers are:

  • David T. Wilson
  • Alex Loukas
  • Sébastien Dutertre
  • Julien Giribaldi
  • Paramjit S. Bansal

The significant volume of publications in biochemistry, genetics and molecular biology, and medicine, as well as the distribution across specialized subfields demonstrate an interdisciplinary approach within life sciences. Their work engages deeply with molecular mechanisms, biochemical processes, and disease-related topics.

Best Publications

  • Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif

    David J Craik;Norelle L Daly;Trudy Bond;Clement Waine

  • The cystine knot motif in toxins and implications for drug design.

    David J. Craik;Norelle L. Daly;Clement Waine

  • Twists, Knots, and Rings in Proteins STRUCTURAL DEFINITION OF THE CYCLOTIDE FRAMEWORK

    K. Johan Rosengren;Norelle L. Daly;Manuel R. Plan;Clement Waine

  • Microcin J25 Has a Threaded Sidechain-to-Backbone Ring Structure and Not a Head-to-Tail Cyclized Backbone

    K.J Rosengren;R.J Clark;N.L Daly;U Goransson

  • Circular proteins in plants: Solution structure of a novel macrocyclic trypsin inhibitor from Momordica cochinchinensis

    Maria Elena Felizmenio-Quimio;Norelle L. Daly;David J. Craik

  • Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the α-conotoxin MII

    Richard J. Clark;Harald Fischer;Louise Dempster;Norelle L. Daly

  • Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?

    Cameron V. Jennings;K. Johan Rosengren;Norelle L. Daly;Manuel Plan

  • Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1.

    Norelle L. Daly;Steve Love;Paul F. Alewood;David J. Craik

  • Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

    Karen S. Harris;Thomas Durek;Quentin Kaas;Aaron G. Poth

  • Discovery, structure and biological activities of cyclotides

    Norelle L. Daly;K. Johan Rosengren;David J. Craik

  • Three-dimensional structure of a cysteine-rich repeat from the low-density lipoprotein receptor

    Norelle L. Daly;Martin J. Scanlon;Julianne T. Djordjevic;Paulus A. Kroon

  • Engineering pro-angiogenic peptides using stable disulfide-rich cyclic scaffolds

    Lai Y. Chan;Sunithi Gunasekera;Sonia T. Henriques;Sonia T. Henriques;Nathalie F. Worth

  • Engineering Stabilized Vascular Endothelial Growth Factor-A Antagonists: Synthesis, Structural Characterization, and Bioactivity of Grafted Analogues of Cyclotides

    Sunithi Gunasekera;Fiona M. Foley;Richard J. Clark;Lillian Sando

  • Bioactive cystine knot proteins

    Norelle L Daly;David J Craik

  • Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

    Sónia Troeira Henriques;Sónia Troeira Henriques;Yen-Hua Huang;K. Johan Rosengren;Henri G. Franquelim

  • Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity

    Shane M. Simonsen;Lillian Sando;K. Johan Rosengren;Conan K. Wang

  • The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

    Susanna S. Ng;Susanna S. Ng;Susanna S. Ng;Fabian De Labastida Rivera;Juming Yan;Juming Yan;Dillon Corvino;Dillon Corvino;Dillon Corvino

  • α-Selenoconotoxins, a New Class of Potent α7 Neuronal Nicotinic Receptor Antagonists

    Christopher J. Armishaw;Norelle L. Daly;Simon T. Nevin;David J. Adams

  • Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides

    Laura Cascales;Sónia T. Henriques;Sónia T. Henriques;Markus C. Kerr;Yen-Hua Huang

  • The cyclotides: novel macrocyclic peptides as scaffolds in drug design.

    David J Craik;Shane Simonsen;Norelle L Daly

  • Discovery of Cyclotides in the Fabaceae Plant Family Provides New Insights into the Cyclization, Evolution, and Distribution of Circular Proteins

    Aaron G Poth;Michelle L Colgrave;Reynold Philip;Bomai Kerenga

  • Approaches to delineate disulfide connectivities in pharmaceutical peptides

    David Wilson;Norelle L. Daly

Frequent Co-Authors

David J. Craik
David J. Craik University of Queensland
Paul F. Alewood
Paul F. Alewood University of Queensland
K. Johan Rosengren
K. Johan Rosengren University of Queensland
David J. Adams
David J. Adams Wellcome Sanger Institute
Alex Loukas
Alex Loukas James Cook University
Richard J. Lewis
Richard J. Lewis University of Queensland
Michelle L. Colgrave
Michelle L. Colgrave Commonwealth Scientific and Industrial Research Organisation
John D. Wade
John D. Wade Florey Institute of Neuroscience and Mental Health
Marilyn A. Anderson
Marilyn A. Anderson La Trobe University
Ross A. D. Bathgate
Ross A. D. Bathgate Florey Institute of Neuroscience and Mental Health

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