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Biology and Biochemistry

D-Index
56
Citations
9578
World Ranking
14589
National Ranking
1044

Overview

Harald Kolmar is affiliated with the Technical University of Darmstadt in Germany and has an extensive publication record spanning biochemistry, genetics, molecular biology, and medicine. Their research predominantly focuses on molecular biology, with significant contributions in subfields such as radiology, nuclear medicine, imaging, oncology, immunology, and biomedical engineering.

The scientist's main areas of study include monoclonal and polyclonal antibodies research, CAR-T cell therapy, viral infectious diseases and gene expression in insects, protein purification and stability, immune cell function and interaction, biochemical and structural characterization, and advanced biosensing techniques and applications.

Harald Kolmar has published numerous research articles in a variety of scientific journals, with some of the more frequent publication venues being Frontiers in Immunology, Methods in Molecular Biology, mAbs, Bioconjugate Chemistry, and Antibodies.

Several recent papers by Kolmar illustrate the scope of their work:

  • Engineering of ultraID, a compact and hyperactive enzyme for proximity-dependent biotinylation in living cells, 2022, Communications Biology
  • Artificial cell synthesis using biocatalytic polymerization-induced self-assembly, 2023, Nature Chemistry
  • Carotenoids in Human Skin In Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors, 2022, Antioxidants
  • Recent progress in transglutaminase-mediated assembly of antibody-drug conjugates, 2020, Analytical Biochemistry
  • From cell line development to the formulated drug product: The art of manufacturing therapeutic monoclonal antibodies, 2020, International Journal of Pharmaceutics

Throughout their career, Harald Kolmar has collaborated frequently with a number of co-authors, including Julius Grzeschik, Björn Hock, Olga Avrutina, Stefania Carrara, and Stefan Zielonka. These collaborations demonstrate a network of ongoing research partnerships.

Best Publications

  • Dimerisation of the Glycophorin A Transmembrane Segment in Membranes Probed with the ToxR Transcription Activator

    Dieter Langosch;Bettina Brosig;Harald Kolmar;Hans-Joachim Fritz

  • Decorating microbes: surface display of proteins on Escherichia coli

    Edwin van Bloois;Remko T. Winter;Harald Kolmar;Marco W. Fraaije

  • The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation

    H. Kolmar;P. R. H. Waller;R. T. Sauer

  • Camelid and shark single domain antibodies: structural features and therapeutic potential.

    Doreen Könning;Stefan Zielonka;Julius Grzeschik;Martin Empting

  • The vsr gene product of E. coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease

    Frank Hennecke;Harald Kolmar;Kerstin Bründl;Hans-Joachim Fritz

  • Ultra-high-throughput screening based on cell-surface display and fluorescence-activated cell sorting for the identification of novel biocatalysts

    Stefan Becker;Hans-Ulrich Schmoldt;Thorsten Michael Adams;Susanne Wilhelm

  • The cystine knot of a squash-type protease inhibitor as a structural scaffold for Escherichia coli cell surface display of conformationally constrained peptides.

    Andreas Christmann;Kerstin Walter;Alexander Wentzel;Ralph Krätzner

  • Structural insights and biomedical potential of IgNAR scaffolds from sharks

    Stefan Zielonka;Martin Empting;Julius Grzeschik;Doreen Könning

  • Bi-specific aptamers mediating tumor cell lysis.

    Achim Boltz;Birgit Piater;Lars Toleikis;Ralf Guenther

  • "Triazole bridge": disulfide-bond replacement by ruthenium-catalyzed formation of 1,5-disubstituted 1,2,3-triazoles.

    Martin Empting;Olga Avrutina;Reinhard Meusinger;Sebastian Fabritz

  • Alternative binding proteins: Biological activity and therapeutic potential of cystine-knot miniproteins

    Harald Kolmar

  • Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins.

    Harald Kolmar

  • The crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa, defines a third class of sulfatases

    Gregor Hagelueken;Thorsten M. Adams;Thorsten M. Adams;Lutz Wiehlmann;Ute Widow

  • Therapeutic antibody engineering by high efficiency cell screening

    Achim Doerner;Laura Rhiel;Stefan Zielonka;Harald Kolmar

  • Inhibition of platelet aggregation by grafting RGD and KGD sequences on the structural scaffold of small disulfide-rich proteins

    Sandy Reiss;Matthias Sieber;Volker Oberle;Alexander Wentzel

  • A generic system for the Escherichia coli cell-surface display of lipolytic enzymes.

    Stefan Becker;Sebastian Theile;Nele Heppeler;Anja Michalczyk

  • A generic approach to engineer antibody pH-switches using combinatorial histidine scanning libraries and yeast display

    Christian Schröter;Ralf Günther;Laura Rhiel;Stefan Becker

  • Display of Passenger Proteins on the Surface of Escherichia coli K-12 by the Enterohemorrhagic E. coli Intimin EaeA

    Alexander Wentzel;Andreas Christmann;Thorsten Adams;Harald Kolmar

  • Engineered Cystine Knot Miniproteins as Potent Inhibitors of Human Mast Cell Tryptase β

    Christian P. Sommerhoff;Olga Avrutina;Hans-Ulrich Schmoldt;Dusica Gabrijelcic-Geiger

  • Single-cell high-throughput screening to identify enantioselective hydrolytic enzymes

    Stefan Becker;Horst Höbenreich;Andreas Vogel;Janina Knorr

Frequent Co-Authors

Karl-Erich Jaeger
Karl-Erich Jaeger Heinrich Heine University Düsseldorf
Dirk W. Heinz
Dirk W. Heinz University of Freiburg
Gerd Buntkowsky
Gerd Buntkowsky Technical University of Darmstadt
Christian P. Sommerhoff
Christian P. Sommerhoff Ludwig-Maximilians-Universität München
Stefan Becker
Stefan Becker Max Planck Society
Andreas Bernkop-Schnürch
Andreas Bernkop-Schnürch University of Innsbruck
Burkhard Tümmler
Burkhard Tümmler Hannover Medical School
Matthias Peipp
Matthias Peipp Kiel University
Manfred T. Reetz
Manfred T. Reetz Max Planck Society
Uwe Haberkorn
Uwe Haberkorn Heidelberg University

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