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Donald M. Engelman

Donald M. Engelman

D-Index & Metrics

Chemistry

D-Index
100
Citations
38685
World Ranking
1269
National Ranking
487

Research.com Recognitions

  • 2004 - Fellow of the American Academy of Arts and Sciences
  • 1997 - Member of the National Academy of Sciences
  • 1978 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

Donald M. Engelman is affiliated with Yale University in the United States. Their research spans several fields including biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, cancer research, immunology, biomedical engineering, and radiology-related disciplines.

The scientist's work covers a variety of main topics such as RNA interference and gene delivery, nanoplatforms for cancer theranostics, lipid membrane structure and behavior, advanced biosensing and bioanalysis techniques, cancer therapeutics and mechanisms, microRNA in disease regulation, and interferon and immune responses.

Frequent co-authors collaborating with Donald M. Engelman include Stephen H. White, Gunnar von Heijne, Yana K. Reshetnyak, Oleg A. Andreev, and Anna Moshnikova.

Key publication venues where their research frequently appears include:

  • Cancer Research
  • Frontiers in Bioengineering and Biotechnology
  • NAR Cancer
  • Proceedings of the National Academy of Sciences
  • Frontiers in Pharmacology

Significant recent papers published by Donald M. Engelman include:

  • Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding, 2020, Frontiers in Bioengineering and Biotechnology
  • Ku80-Targeted pH-Sensitive Peptide-PNA Conjugates Are Tumor Selective and Sensitize Cancer Cells to Ionizing Radiation, 2020, Molecular Cancer Research
  • pHLIP ICG for delineation of tumors and blood flow during fluorescence-guided surgery, 2020, Scientific Reports
  • Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity, 2021, NAR Cancer
  • Kinetics of pHLIP peptide insertion into and exit from a membrane, 2020, Proceedings of the National Academy of Sciences

In addition to journal publications, Donald M. Engelman has contributed to book publications, including the title Cell Boundaries, published by Garland Science eBooks in 2021.

The scientist has been recognized with several awards, including being named a Fellow of the American Academy of Arts and Sciences in 2004, a Member of the National Academy of Sciences in 1997, and a Fellow of the John Simon Guggenheim Memorial Foundation in 1978.

Best Publications

  • Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins.

    D M Engelman;T A Steitz;A Goldman

  • Membrane protein folding and oligomerization: the two-stage model.

    J L Popot;D M Engelman

  • A transmembrane helix dimer: structure and implications.

    Kevin R. MacKenzie;James H. Prestegard;Donald M. Engelman

  • Membranes are more mosaic than fluid

    Donald M. Engelman

  • The GxxxG motif: A framework for transmembrane helix-helix association

    William P Russ;Donald M Engelman

  • The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis

    D.M. Engelman;T.A. Steitz

  • Lipid bilayer thickness varies linearly with acyl chain length in fluid phosphatidylcholine vesicles

    Barbara A. Lewis;Donald M. Engelman

  • Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with β-branched residues at neighboring positions

    Alessandro Senes;Mark Gerstein;Donald M Engelman

  • Helical Membrane Protein Folding, Stability, and Evolution

    Jean-Luc Popot;Donald M. Engelman

  • Sequence specificity in the dimerization of transmembrane alpha-helices.

    Mark A. Lemmon;John M. Flanagan;Herbert R. Treutlein;Jian Zhang

  • Glycophorin A dimerization is driven by specific interactions between transmembrane alpha helices

    M.A. Lemmon;J.M. Flanagan;J.F. Hunt;B.D. Adair

  • The Cα—H⋅⋅⋅O hydrogen bond: A determinant of stability and specificity in transmembrane helix interactions

    Alessandro Senes;Iban Ubarretxena-Belandia;Donald M. Engelman

  • Path of the polypeptide in bacteriorhodopsin

    D M Engelman;R Henderson;A D McLachlan;B A Wallace

  • Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol

    Kakoli Mitra;Iban Ubarretxena-Belandia;Iban Ubarretxena-Belandia;Tomohiko Taguchi;Graham Warren

  • Two EGF molecules contribute additively to stabilization of the EGFR dimer

    Mark A. Lemmon;Zimei Bu;John Edward Simon Durham Ladbury;Min Zhou;Min Zhou

  • Interhelical hydrogen bonding drives strong interactions in membrane proteins.

    Fang Xiao Zhou;Melanie J. Cocco;William P. Russ;Axel T. Brunger;Axel T. Brunger

  • TOXCAT: A measure of transmembrane helix association in a biological membrane

    William P. Russ;Donald M. Engelman

  • Bilayer structure in membranes.

    M. H. F. Wilkins;A. E. Blaurock;A. E. Blaurock;D. M. Engelman;D. M. Engelman

  • Polar residues drive association of polyleucine transmembrane helices

    Fang Xiao Zhou;Helen J. Merianos;Axel T. Brunger;Donald M. Engelman

  • A dimerization motif for transmembrane α–helices

    Mark A. Lemmon;Herbert R. Treutlein;Herbert R. Treutlein;Herbert R. Treutlein;Paul D. Adams;Axel T. Brünger;Axel T. Brünger

  • Refolding of bacteriorhodopsin in lipid bilayers: A thermodynamically controlled two-stage process

    Jean-Luc Popot;Sue-Ellen Gerchman;Donald M. Engelman

  • Annual review of biophysics and biomolecular structure

    Donald M. Engelman;Charles R. Cantor;Thomas D. Pollard;Robert M. Stroud

Frequent Co-Authors

Peter B. Moore
Peter B. Moore Yale University
Axel T. Brunger
Axel T. Brunger Stanford University
Mark A. Lemmon
Mark A. Lemmon Yale University
Mark Gerstein
Mark Gerstein Yale University
Thomas A. Steitz
Thomas A. Steitz Yale University
Giuseppe Zaccai
Giuseppe Zaccai Centre national de la recherche scientifique, CNRS
Daniel DiMaio
Daniel DiMaio Yale University
Venki Ramakrishnan
Venki Ramakrishnan MRC Laboratory of Molecular Biology
Jason S. Lewis
Jason S. Lewis Memorial Sloan Kettering Cancer Center
John F. Hunt
John F. Hunt Columbia University

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