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Chemistry

D-Index
80
Citations
20321
World Ranking
3471
National Ranking
1134

Overview

Steven O. Smith is affiliated with Stony Brook University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on several subfields including Molecular Biology, Physiology, Cellular and Molecular Neuroscience, Neurology, and Clinical Biochemistry.

The scientist's published work explores a variety of topics relevant to biomedical research. Major themes include:

  • Alzheimer's disease research and treatments
  • Advanced Glycation End Products research
  • Receptor Mechanisms and Signaling
  • Amyloidosis: Diagnosis, Treatment, Outcomes
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Photoreceptor and optogenetics research
  • Intracerebral and Subarachnoid Hemorrhage Research

Major publication venues for Steven O. Smith include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Biochemistry
  • iScience
  • Journal of Structural Biology

Frequent collaborators in their research are:

  • William E. Van Nostrand
  • Brandon A. Irizarry
  • Stefan N. Constantinescu
  • Xiaoyue Zhu
  • Nicolas Papadopoulos

Recent papers authored or co-authored by Steven O. Smith include:

  • "Human cerebral vascular amyloid contains both antiparallel and parallel in-register Aβ40 fibrils", 2021, Journal of Biological Chemistry
  • "Deconstructing the transmembrane core of class A G protein-coupled receptors", 2021, Trends in Biochemical Sciences
  • "MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491", 2020, Blood
  • "Mechanism of Activation of the Visual Receptor Rhodopsin", 2023, Annual Review of Biophysics
  • "An electrostatic cluster guides Aβ40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy", 2024, Journal of Structural Biology

Best Publications

  • Ramped-Amplitude Cross Polarization in Magic-Angle-Spinning NMR

    G. Metz;Xiaoling Wu;S. O. Smith

  • Structural conversion of neurotoxic amyloid-[beta]1-42 oligomers to fibrils

    Mahiuddin Ahmed;Judianne Davis;Darryl Aucoin;Takeshi Sato

  • Prasugrel versus clopidogrel for acute coronary syndromes without revascularization

    Matthew T. Roe;Paul W. Armstrong;Keith A.A. Fox;Harvey D. White

  • A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

    Tatjana Dragic;Alexandra Trkola;Daniah A. D. Thompson;Emmanuel G. Cormier

  • Variable-Amplitude Cross-Polarization MAS NMR

    O. B. Peersen;Xiaoling Wu;I. Kustanovich;S. O. Smith

  • Helix packing in polytopic membrane proteins: role of glycine in transmembrane helix association.

    Maryam M. Javadpour;Markus Eilers;Markus Eilers;Michel Groesbeek;Steven O. Smith

  • Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins.

    Alok Gambhir;Gyöngyi Hangyás-Mihályné;Irina Zaitseva;David S. Cafiso

  • Internal packing of helical membrane proteins

    Markus Eilers;Srinivasan C. Shekar;Ted Shieh;Steven O. Smith

  • High-resolution Atomic Force Microscopy of Soluble Aβ42 Oligomers

    Iris A. Mastrangelo;Mahiuddin Ahmed;Takeshi Sato;Wei Liu

  • Vibrational analysis of the all-trans-retinal chromophore in light-adapted bacteriorhodopsin

    Steven O. Smith;Mark S. Braiman;Anne B. Myers;Johannes A. Pardoen

  • Comparison of Helix Interactions in Membrane and Soluble α-Bundle Proteins

    Markus Eilers;Ashish B. Patel;Wei Liu;Steven O. Smith

  • Determination of retinal chromophore structure in bacteriorhodopsin with resonance Raman spectroscopy.

    Steven O. Smith;Johan Lugtenburg;Richard A. Mathies

  • Dark-adapted bacteriorhodopsin contains 13-cis, 15-syn and all-trans, 15-anti retinal Schiff bases

    Gerard S. Harbison;Steven O. Smith;Johannes A. Pardoen;Chris Winkel

  • Crystallographic structure of the K intermediate of bacteriorhodopsin: conservation of free energy after photoisomerization of the retinal.

    Brigitte Schobert;Jill Cupp-Vickery;Viktor Hornak;Steven O. Smith

  • Solid-state 13C NMR detection of a perturbed 6-s-trans chromophore in bacteriorhodopsin.

    G. S. Harbison;S. O. Smith;J. A. Pardoen;J. M. L. Courtin

  • Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.

    Takeshi Sato;Pascal Kienlen-Campard;Mahiuddin Ahmed;Wei Liu

  • Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity

    Ali Reza A. Ladiwala;Jeffrey Litt;Ravi S. Kane;Darryl S. Aucoin

  • Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation.

    Shivani Ahuja;Viktor Hornak;Elsa C Y Yan;Elsa C Y Yan;Natalie Syrett

  • Structure and Activation of the Visual Pigment Rhodopsin

    Steven O. Smith

  • Active and Inactive Orientations of the Transmembrane and Cytosolic Domains of the Erythropoietin Receptor Dimer

    Nadine Seubert;Yohan Royer;Yohan Royer;Judith Staerk;Judith Staerk;Katharina F Kubatzky;Katharina F Kubatzky

  • Structure of the transmembrane dimer interface of glycophorin A in membrane bilayers

    Steven O. Smith;David Song;Srinivasan Shekar;Michel Groesbeek

Frequent Co-Authors

Stefan N. Constantinescu
Stefan N. Constantinescu Ludwig Cancer Research
Saburo Aimoto
Saburo Aimoto Osaka University
Johan Lugtenburg
Johan Lugtenburg Leiden University
Richard A. Mathies
Richard A. Mathies University of California, Berkeley
Jean-Noël Octave
Jean-Noël Octave Université Catholique de Louvain
Mordechai Sheves
Mordechai Sheves Weizmann Institute of Science
Judith Herzfeld
Judith Herzfeld Brandeis University
Daniel DiMaio
Daniel DiMaio Yale University
Daniel P. Raleigh
Daniel P. Raleigh Stony Brook University

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