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Stefan N. Constantinescu

Stefan N. Constantinescu

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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
24141
World Ranking
5844
National Ranking
95

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

Stefan N. Constantinescu is affiliated with Ludwig Cancer Research in Belgium and has a research focus primarily in the field of Medicine. Their work spans several subfields including Hematology, Genetics, Molecular Biology, Immunology, and Infectious Diseases.

The scientist's research topics cover a range of specific areas such as:

  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Acute Myeloid Leukemia Research
  • Chronic Myeloid Leukemia Treatments
  • Kruppel-like factors research
  • Platelet Disorders and Treatments
  • SARS-CoV-2 and COVID-19 Research
  • Cytokine Signaling Pathways and Interactions

Stefan N. Constantinescu has published extensively in several scientific venues, with frequent publications in:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Experimental Medicine
  • HemaSphere
  • Nature Communications

Recent papers authored or co-authored by the scientist include:

  • Advances in covalent kinase inhibitors, 2020, Chemical Society Reviews
  • Studying severe long COVID to understand post-infectious disorders beyond COVID-19, 2022, Nature Medicine
  • Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia, 2022, The Journal of Experimental Medicine
  • Autoantibodies against type I IFNs in patients with critical influenza pneumonia, 2022, The Journal of Experimental Medicine
  • Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19, 2023, Genome Medicine

Collaborations are a notable part of their work, frequently working with co-authors such as:

  • Nicolas Papadopoulos
  • William Vainchenker
  • Jacques Fellay
  • Rabih Halwani
  • Petter Brodin

Best Publications

  • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

    Chloé James;Valérie Ugo;Jean-Pierre Le Couédic;Judith Staerk

  • Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in Humans

    Suraj Peri;Suraj Peri;J. Daniel Navarro;J. Daniel Navarro;Ramars Amanchy;Troels Z. Kristiansen;Troels Z. Kristiansen

  • Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths.

    Paul Bastard;Adrian Gervais;Adrian Gervais;Tom Le Voyer;Tom Le Voyer;Jérémie Rosain;Jérémie Rosain

  • JAK/STAT signaling in hematological malignancies

    W. Vainchenker;W. Vainchenker;W. Vainchenker;Stefan N. Constantinescu;Stefan N. Constantinescu

  • Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10.

    Diane Lejeune;Laure Dumoutier;Stefan Constantinescu;Wiebe Kruijer

  • NetPath: a public resource of curated signal transduction pathways

    Kumaran Kandasamy;S. Sujatha Mohan;Rajesh Raju;Shivakumar Keerthikumar

  • New mutations and pathogenesis of myeloproliferative neoplasms.

    William Vainchenker;William Vainchenker;François Delhommeau;François Delhommeau;Stefan N. Constantinescu;Stefan N. Constantinescu;Olivier A. Bernard;Olivier A. Bernard;Olivier A. Bernard

  • Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

    Xuedong Liu;Yin Sun;Stefan N. Constantinescu;Edmund Karam

  • Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia

    Elisabetta Flex;Valentina Petrangeli;Lorenzo Stella;Sabina Chiaretti

  • The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.

    Lily Jun shen Huang;Stefan N. Constantinescu;Harvey F. Lodish

  • Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

    Petter S. Woll;Una Kjällquist;Onima Chowdhury;Helen Doolittle

  • Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants

    Ilyas Chachoua;Ilyas Chachoua;Christian Pecquet;Christian Pecquet;Mira El-Khoury;Harini Nivarthi

  • Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain.

    Stefan N. Constantinescu;Tzvia Keren;Merav Socolovsky;Hyung-song Nam

  • Whole exome sequencing identifies novel MPL and JAK2 mutations in triple negative myeloproliferative neoplasms

    Jelena D. Milosevic Feenstra;Harini Nivarthi;Heinz Gisslinger;Emilie Leroy;Emilie Leroy

  • The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction

    Stefan N. Constantinescu;Saghi Ghaffari;Harvey F. Lodish

  • JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies

    William Vainchenker;Alexandra Dusa;Alexandra Dusa;Stefan N. Constantinescu;Stefan N. Constantinescu

  • Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.

    Caroline Marty;Caroline Marty;Caroline Marty;Christian Pecquet;Christian Pecquet;Harini Nivarthi;Mira El-Khoury;Mira El-Khoury;Mira El-Khoury

  • Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.

    Takeshi Sato;Pascal Kienlen-Campard;Mahiuddin Ahmed;Wei Liu

  • JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation - Cross-talk with IGF1 receptor

    Judith Staerk;Anders Kallin;Jean-Baptiste Demoulin;William Vainchenker

  • CYTOKINE RECEPTOR SIGNAL TRANSDUCTION AND THE CONTROL OF HEMATOPOIETIC CELL DEVELOPMENT

    Stephanie S. Watowich;Hong Wu;Merav Socolovsky;Ursula Klingmuller

Frequent Co-Authors

William Vainchenker
William Vainchenker Institut Gustave Roussy
Isabelle Plo
Isabelle Plo University of Paris-Saclay
Steven O. Smith
Steven O. Smith Stony Brook University
Jean-Noël Octave
Jean-Noël Octave Université Catholique de Louvain
Jean-Luc Villeval
Jean-Luc Villeval Institut Gustave Roussy
Jean-Christophe Renauld
Jean-Christophe Renauld Université Catholique de Louvain
Pierre J. Courtoy
Pierre J. Courtoy Université Catholique de Louvain
Eric Solary
Eric Solary Institut Gustave Roussy
Sten Eirik W. Jacobsen
Sten Eirik W. Jacobsen University of Oxford

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