World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
64
Citations
20598
World Ranking
1711
National Ranking
29

Overview

Radek C. Skoda is affiliated with the University Hospital of Basel in Switzerland. Their research focuses primarily on medicine, with a significant concentration in hematology and genetics, complemented by work in molecular biology, rheumatology, and oncology.

The scientist's recent publications cover a range of topics within hematological cancers and molecular mechanisms. Key papers include:

  • "Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia," 2022, Blood
  • "Genetic basis and molecular profiling in myeloproliferative neoplasms," 2022, Blood
  • "Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation," 2020, Blood
  • "JAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality," 2021, Blood
  • "Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm," 2022, Nature Communications

Skoda's work addresses critical areas such as myeloproliferative neoplasms and acute myeloid leukemia, which are reflected in their main topics of research:

  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Acute Myeloid Leukemia Research
  • Chronic Myeloid Leukemia Treatments
  • Kruppel-like factors research
  • Eosinophilic Disorders and Syndromes
  • Cytokine Signaling Pathways and Interactions
  • Hemoglobinopathies and Related Disorders

Frequent publication venues include journals that specialize in hematology and related biomedical sciences, notably:

  • Blood (18 publications)
  • HemaSphere (5 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (4 publications)
  • Blood Advances (3 publications)
  • Nature Communications (2 publications)

Collaboration plays a significant role in Skoda's research output, with numerous co-authors contributing to their work. Among the most frequent collaborators are:

  • Hui Hao-Shen (19 joint publications)
  • Shivam Rai (14 joint publications)
  • Marc Usart (14 joint publications)
  • Jan Stetka (13 joint publications)
  • Nils Hansen (10 joint publications)

Overall, Radek C. Skoda's scientific contributions intersect the genetic and molecular bases of hematological diseases, contributing to the understanding and potential treatment strategies for myeloproliferative and leukemic conditions.

Best Publications

  • Defective STAT signaling by the leptin receptor in diabetic mice.

    Nico Ghilardi;Sandra Ziegler;Adrian Wiestner;Ruedi Stoffel

  • Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.

    F J Gonzalez;R C Skoda;S Kimura;M Umeno

  • Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms

    Pontus Lundberg;Axel Karow;Ronny Nienhold;Renate Looser

  • The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

    S Kimura;M Umeno;R C Skoda;U A Meyer

  • Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo

    Unknown

  • The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

    Nico Ghilardi;Radek C. Skoda

  • Platelets regulate lymphatic vascular development through CLEC-2–SLP-76 signaling

    Cara C. Bertozzi;Alec A. Schmaier;Patricia Mericko;Paul R. Hess

  • Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

    Lorena Arranz;Abel Sánchez-Aguilera;Daniel Martín-Pérez;Joan Isern

  • Leukemic blasts in transformed JAK2-V617F –positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation.

    Alexandre Theocharides;Marjorie Boissinot;François Girodon;Richard Garand

  • Talin is required for integrin-mediated platelet function in hemostasis and thrombosis

    Brian G. Petrich;Patrizia Marchese;Zaverio M. Ruggeri;Saskia Spiess

  • Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders

    Unknown

  • The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera

    Unknown

  • The Pseudokinase Domain of JAK2 Is a Dual-Specificity Protein Kinase That Negatively Regulates Cytokine Signaling

    Daniela Ungureanu;Jinhua Wu;Jinhua Wu;Tuija Pekkala;Yashavanthi Niranjan

  • Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs.

    Radek C. Skoda;Frank J. Gonzalez;Anne Demierre;Urs A. Meyer

  • Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2.

    Robert Kralovics;Soon Siong Teo;Soon Siong Teo;Andreas S. Buser;Andreas S. Buser;Martin Brutsche;Martin Brutsche

  • Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion

    Catherine Léon;Anita Eckly;Béatrice Hechler;Boris Aleil

  • Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.

    R. C. Skoda;D. C. Seldin;Ming-Ko Chiang;C. L. Peichel

  • Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms.

    Franz X. Schaub;Renate Looser;Sai Li;Hui Hao-Shen

  • The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms.

    Urs A. Meyer;Radek C. Skoda;Ulrich M. Zanger

  • Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene

    Nico Ghilardi;Adrian Wiestner;Masahiro Kikuchi;Akimichi Ohsaka

Frequent Co-Authors

André Tichelli
André Tichelli University Hospital of Basel
Jakob Passweg
Jakob Passweg University Hospital of Basel
Mario Cazzola
Mario Cazzola University of Pavia
Nico Ghilardi
Nico Ghilardi Genentech
Markus G. Manz
Markus G. Manz University of Zurich
Francesco Passamonti
Francesco Passamonti University of Milan
Daniela Pietra
Daniela Pietra University of Pavia
Alessandro M. Vannucchi
Alessandro M. Vannucchi University of Florence
Stuart H. Orkin
Stuart H. Orkin Harvard University
Josef T. Prchal
Josef T. Prchal University of Utah

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