World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
14539
World Ranking
7895
National Ranking
3582

Overview

Xian-Cheng Jiang is affiliated with SUNY Downstate Medical Center in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research covers a broad range of topics primarily related to lipid metabolism, sphingolipid signaling, and cardiovascular diseases.

The scientist's work has been published in various notable journals, including the following frequent publication venues:

  • Arteriosclerosis Thrombosis and Vascular Biology
  • Journal of Biological Chemistry
  • Advances in experimental medicine and biology
  • Atherosclerosis
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Key areas of study include molecular biology, physiology, cell biology, nuclear and high energy physics, and biochemistry. Their research topics particularly involve:

  • Sphingolipid Metabolism and Signaling
  • Lipid Membrane Structure and Behavior
  • Erythrocyte Function and Pathophysiology
  • Lipid metabolism and biosynthesis
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Lysosomal Storage Disorders Research
  • Peroxisome Proliferator-Activated Receptors

Among the recent papers authored or co-authored by Jiang are:

  • The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3, 2021, Nature Communications
  • Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer, 2020, Acta Pharmacologica Sinica
  • The Role of Phospholipid Transfer Protein in the Development of Atherosclerosis, 2021, Current Atherosclerosis Reports
  • Effect of liver total sphingomyelin synthase deficiency on plasma lipid metabolism, 2021, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • Sphingolipids and Cholesterol, 2022, Advances in experimental medicine and biology

Collaborative work features frequent co-authors such as Zhiqiang Li, Mulin He, Yeun-po Chiang, Tilla S. Worgall, and Yang Chen. These collaborations have contributed to the interconnected study of lipid metabolism and related pathologies.

In addition to journal articles, Jiang has authored books published by Springer Nature and Frontiers Media. Titles include:

  • Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease, 2020
  • Sphingolipid Metabolism and Metabolic Disease, 2022
  • Lipid Metabolism and Human Diseases, 2022

Best Publications

  • Cholesterol Efflux and Atheroprotection Advancing the Concept of Reverse Cholesterol Transport

    Robert S. Rosenson;H. Bryan Brewer;W. Sean Davidson;Zahi A. Fayad

  • Plasma Sphingomyelin Level as a Risk Factor for Coronary Artery Disease

    Xian Cheng Jiang;Furcy Paultre;Thomas A. Pearson;Roberta G. Reed

  • Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels

    Xian-cheng Jiang;Can Bruce;Jefferson Mar;Min Lin

  • Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice.

    L. B. Agellon;A. Walsh;T. Hayek;P. Moulin

  • Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

    Tae Sik Park;Tae Sik Park;Yunying Hu;Hye Lim Noh;Konstantinos Drosatos

  • Antidiabetic Action of a Liver X Receptor Agonist Mediated By Inhibition of Hepatic Gluconeogenesis

    Guoqing Cao;Yu Liang;Carol L. Broderick;Brian A. Oldham

  • Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH IMPLICATIONS FOR ATHEROSCLEROTIC LESION DEVELOPMENT

    Scott L. Schissel;Xian-cheng Jiang;Judith Tweedie-Hardman;Tae-sook Jeong

  • Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice

    Mohammad Reza Hojjati;Zhiqiang Li;Hongwen Zhou;Songshan Tang

  • Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency

    Xian Cheng Jiang;Shucun Qin;Chunping Qiao;Koichi Kawano

  • HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway

    Fumihiko Matsuura;Nan Wang;Wengen Chen;Xian-Cheng Jiang

  • Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences.

    Xian Cheng Jiang;Luis B. Agellon;Annemarie Walsh;Jan L. Breslow

  • Phospholipid transfer protein is regulated by liver X receptors in vivo.

    Guoqing Cao;Thomas P. Beyer;Xiao Ping Yang;Robert J. Schmidt

  • Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice.

    Mohammad Reza Hojjati;Zhiqiang Li;Xian-Cheng Jiang

  • l-Arginine Prevents Xanthoma Development and Inhibits Atherosclerosis in LDL Receptor Knockout Mice

    Walif Aji;Stefano Ravalli;Matthias Szabolcs;Xian Cheng Jiang

  • Inhibition of Cholesteryl Ester Transfer Protein by Torcetrapib Modestly Increases Macrophage Cholesterol Efflux to HDL

    Laurent Yvan-Charvet;Fumihiko Matsuura;Nan Wang;Mark J. Bamberger

  • Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity

    Zhiqiang Li;Hongqi Zhang;Hongqi Zhang;Jing Liu;Chien-Ping Liang

  • A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes

    Yu Liang;Suizhen Lin;Thomas P. Beyer;Youyan Zhang

  • Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes.

    Xian-cheng Jiang;Omar L. Francone;Can Bruce;Ross Milne

  • 1999 George Lyman Duff memorial lecture: lipid transfer proteins, HDL metabolism, and atherogenesis.

    Alan R. Tall;Xian-cheng Jiang;Yi Luo;David Silver

  • Sphingomyelin Synthase 2 Deficiency Attenuates NFκB Activation

    Tiruneh K. Hailemariam;Chongmin Huan;Jing Liu;Zhiqiang Li

Frequent Co-Authors

Alan R. Tall
Alan R. Tall Columbia University
M. Mahmood Hussain
M. Mahmood Hussain Huazhong University of Science and Technology
Laurent Lagrost
Laurent Lagrost Grenoble Alpes University
Karl J. Lackner
Karl J. Lackner Johannes Gutenberg University of Mainz
Stefan Blankenberg
Stefan Blankenberg Universität Hamburg
Ira J. Goldberg
Ira J. Goldberg New York University
Karl Werdan
Karl Werdan Martin Luther University Halle-Wittenberg
Jan L. Breslow
Jan L. Breslow Rockefeller University
Ira Tabas
Ira Tabas Columbia University
Junbo Ge
Junbo Ge Fudan University

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