His primary areas of study are Ceramide, Internal medicine, Endocrinology, Sphingolipid and Insulin resistance. Scott A. Summers combines subjects such as Lipid signaling, Insulin and Cell biology with his study of Ceramide. The various areas that Scott A. Summers examines in his Lipid signaling study include Protein kinase B and Akt/PKB signaling pathway.
His work on AMPK as part of general Cell biology research is frequently linked to Ceramidase activity, bridging the gap between disciplines. He is studying Receptor, which is a component of Internal medicine. He has included themes like Proinflammatory cytokine, Diabetes mellitus, Type 2 Diabetes Mellitus and Lipotoxicity in his Sphingolipid study.
The scientist’s investigation covers issues in Internal medicine, Endocrinology, Ceramide, Sphingolipid and Insulin resistance. His Steatosis, Glucose homeostasis and White adipose tissue study, which is part of a larger body of work in Internal medicine, is frequently linked to Downregulation and upregulation, bridging the gap between disciplines. In his study, which falls under the umbrella issue of Endocrinology, Dihydroceramide desaturase and Glycogen synthase is strongly linked to Protein kinase B.
Scott A. Summers has researched Ceramide in several fields, including Inflammation, Proinflammatory cytokine, Lipid signaling, Adiponectin and Programmed cell death. His Sphingolipid research is multidisciplinary, incorporating elements of Diabetes mellitus, Dyslipidemia, Type 2 Diabetes Mellitus and Cholesterol. His work deals with themes such as Steatohepatitis, Metabolic syndrome and Skeletal muscle, which intersect with Insulin resistance.
Scott A. Summers mainly focuses on Ceramide, Internal medicine, Endocrinology, Sphingolipid and Diabetes mellitus. His Ceramide research includes themes of Homeostasis, Coronary artery disease, Inflammation, Insulin resistance and Steatohepatitis. The Insulin resistance study combines topics in areas such as Adipose tissue, Steatosis, Dyslipidemia and Skeletal muscle.
His Sphingolipid research is multidisciplinary, incorporating perspectives in Serine C-palmitoyltransferase, Progenitor cell and Fatty acid. Scott A. Summers interconnects Heart disease and Bioinformatics in the investigation of issues within Diabetes mellitus. His studies deal with areas such as Leptin and White adipose tissue as well as Insulin.
Scott A. Summers spends much of his time researching Ceramide, Diabetes mellitus, Sphingolipid, Coronary artery disease and Heart disease. His Sphingolipid research incorporates themes from Internal medicine, Endocrinology and Insulin resistance. In the subject of general Insulin resistance, his work in Lipotoxicity is often linked to Leptin Deficiency, thereby combining diverse domains of study.
His studies in Coronary artery disease integrate themes in fields like Cardiovascular health, MEDLINE and Intensive care medicine. He focuses mostly in the field of Heart disease, narrowing it down to topics relating to Calcium signaling and, in certain cases, Metabolism. The study incorporates disciplines such as Mitochondrion and Cell biology in addition to Glycolysis.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation
Aimee D. Kohn;Scott A. Summers;Morris J. Birnbaum;Richard A. Roth.
Journal of Biological Chemistry (1996)
Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance
William L. Holland;Joseph T. Brozinick;Li Ping Wang;Eric D. Hawkins.
Cell Metabolism (2007)
Ceramides in insulin resistance and lipotoxicity.
Scott A Summers.
Progress in Lipid Research (2006)
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
William L. Holland;Russell A. Miller;Zhao V. Wang;Kai Sun.
Nature Medicine (2011)
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids.
Jose Antonio Chavez;Trina A. Knotts;Li-Ping Wang;Guibin Li.
Journal of Biological Chemistry (2003)
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
William L. Holland;Benjamin T. Bikman;Li Ping Wang;Guan Yuguang.
Journal of Clinical Investigation (2011)
Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism
William L. Holland;Scott A. Summers.
Endocrine Reviews (2008)
Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes.
Jose Antonio Chavez;Scott A Summers.
Archives of Biochemistry and Biophysics (2003)
A Ceramide-Centric View of Insulin Resistance
Jose A. Chavez;Scott A. Summers;Scott A. Summers.
Cell Metabolism (2012)
Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide
Scott A. Summers;Luis A. Garza;Honglin Zhou;Morris J. Birnbaum.
Molecular and Cellular Biology (1998)
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