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Biology and Biochemistry

D-Index
62
Citations
22133
World Ranking
10545
National Ranking
4578

Overview

Scott A. Summers is affiliated with the University of Utah in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. The subfields of their work include Molecular Biology, Cancer Research, Physiology, Epidemiology, and Surgery.

The scientist's research covers several key topics:

  • Sphingolipid Metabolism and Signaling
  • Peroxisome Proliferator-Activated Receptors
  • Cancer, Lipids, and Metabolism
  • Liver Disease Diagnosis and Treatment
  • Lipid Membrane Structure and Behavior
  • Metabolism, Diabetes, and Cancer
  • Diet, Metabolism, and Disease

A selection of recent papers authored or co-authored by Summers includes:

  • Ceramides and other sphingolipids as drivers of cardiovascular disease, 2021, Nature Reviews Cardiology
  • Ceramides in Metabolism: Key Lipotoxic Players, 2020, Annual Review of Physiology
  • Metabolic dysfunction and obesity-related cancer: Beyond obesity and metabolic syndrome, 2022, Obesity
  • Reign in the membrane: How common lipids govern mitochondrial function, 2020, Current Opinion in Cell Biology
  • Adipocyte Ceramides-The Nexus of Inflammation and Metabolic Disease, 2020, Frontiers in Immunology

Summers has frequently collaborated with several co-authors, including:

  • William L. Holland
  • J. Alan Maschek
  • James E. Cox
  • Rebekah J. Nicholson
  • Mary C. Playdon

The scientist's work has been published in a variety of venues, with recurring publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of the American Society of Nephrology
  • Scientific Reports
  • Frontiers in Endocrinology
  • Diabetes

Best Publications

  • Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

    Aimee D. Kohn;Scott A. Summers;Morris J. Birnbaum;Richard A. Roth

  • Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance

    William L. Holland;Joseph T. Brozinick;Li Ping Wang;Eric D. Hawkins

  • Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

    William L. Holland;Russell A. Miller;Zhao V. Wang;Kai Sun

  • Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.

    William L. Holland;Benjamin T. Bikman;Li Ping Wang;Guan Yuguang

  • A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids.

    Jose Antonio Chavez;Trina A. Knotts;Li Ping Wang;Guibin Li

  • A Ceramide-Centric View of Insulin Resistance

    Jose A. Chavez;Scott A. Summers;Scott A. Summers

  • Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism

    William L. Holland;Scott A. Summers

  • Ceramides – Lipotoxic Inducers of Metabolic Disorders

    Bhagirath Chaurasia;Scott A. Summers

  • Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes.

    Jose Antonio Chavez;Scott A Summers

  • Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide

    Scott A. Summers;Luis A. Garza;Honglin Zhou;Morris J. Birnbaum

  • Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

    Suzanne Stratford;Kyle L. Hoehn;Feng Liu;Scott A. Summers

  • Ceramides as modulators of cellular and whole-body metabolism.

    Benjamin T. Bikman;Scott A. Summers

  • CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

    Suryaprakash Raichur;Siew Tein Wang;Puck Wee Chan;Ying Li

  • INHIBITION OF AKT KINASE BY CELL-PERMEABLE CERAMIDE AND ITS IMPLICATIONS FOR CERAMIDE-INDUCED APOPTOSIS

    Honglin Zhou;Scott A. Summers;Morris J. Birnbaum;Randall N. Pittman

  • Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

    Peter J. Meikle;Scott A. Summers

  • Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt

    Aimee D. Kohn;Andreas Barthel;Kristina S. Kovacina;Annegret Boge

  • Caffeine stimulates hepatic lipid metabolism by the autophagy‐lysosomal pathway in mice

    Rohit A. Sinha;Benjamin L. Farah;Brijesh K. Singh;Monowarul M. Siddique

  • Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.

    Bhagirath Chaurasia;Trevor S. Tippetts;Rafael Mayoral Monibas;Jinqi Liu

  • Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

    Rohit Anthony Sinha;Seo Hee You;Jin Zhou;Mobin M. Siddique

  • The Role of Glycogen Synthase Kinase 3β in Insulin-stimulated Glucose Metabolism

    Scott A. Summers;Aimee W. Kao;Aimee D. Kohn;Gillian S. Backus

Frequent Co-Authors

William L. Holland
William L. Holland University of Utah
Morris J. Birnbaum
Morris J. Birnbaum Pfizer (United States)
Jared Rutter
Jared Rutter University of Utah
James C. Cox
James C. Cox Georgia State University
Guanghou Shui
Guanghou Shui Chinese Academy of Sciences
E. Dale Abel
E. Dale Abel University of California, Los Angeles
Markus R. Wenk
Markus R. Wenk Hamad bin Khalifa University
Olga Ilkayeva
Olga Ilkayeva Duke University
Christopher B. Newgard
Christopher B. Newgard Duke University
Boon-Huat Bay
Boon-Huat Bay National University of Singapore

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