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Best Scientists

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167
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Medicine

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169
Citations
116509
World Ranking
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Research.com Recognitions

  • 2025 - Research.com Best Scientists Award
  • 2002 - Fellow of the American Academy of Arts and Sciences
  • 2000 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Jerrold M. Olefsky is affiliated with the University of California, San Diego in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant portion of work also in the field of medicine. Areas of specialization include molecular biology, cancer research, epidemiology, immunology, and physiology.

The scientist's research centers on key topics such as microRNA in disease regulation, extracellular vesicles in disease, adipokines, inflammation, and metabolic diseases. Further interests include adipose tissue and metabolism, cardiovascular disease and adiposity, liver disease diagnosis and treatment, and circular RNAs in diseases.

Recent publications reflect a focus on metabolism, inflammation, and intercellular communication:

  • Inflammation in obesity, diabetes, and related disorders (2022, Immunity)
  • Exosomes as mediators of intercellular crosstalk in metabolism (2021, Cell Metabolism)
  • MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice (2021, Cell Metabolism)
  • Chronic tissue inflammation and metabolic disease (2021, Genes & Development)
  • Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth (2022, Nature Cell Biology)

Their work is published frequently in venues such as Cell Metabolism, Nature Metabolism, Immunity, bioRxiv (Cold Spring Harbor Laboratory), and Gastroenterology. Cell Metabolism stands out with the highest number of publications.

They have collaborated often with researchers including Theresa V. Rohm, Roi Isaac, Wei Ying, Gautam Bandyopadhyay, and Felipe C.G. Reis.

Jerrold M. Olefsky has been recognized by membership and fellowship in prestigious academic and professional bodies:

  • Fellow of the American Academy of Arts and Sciences (2002)
  • Member of the National Academy of Medicine (2000)
  • Member of the Association of American Physicians

Best Publications

  • Macrophages, Inflammation, and Insulin Resistance

    Jerrold M. Olefsky;Christopher K. Glass

  • GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin Sensitizing Effects

    Da Young Oh;Saswata Talukdar;Eun Ju Bae;Takeshi Imamura

  • IKK-beta links inflammation to obesity-induced insulin resistance.

    Melek C. Arkan;Andrea L. Hevener;Florian R. Greten;Shin Maeda

  • Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

    Jill C. Milne;Philip D. Lambert;Simon Schenk;David P. Carney

  • Inflammatory mechanisms linking obesity and metabolic disease

    Alan R. Saltiel;Jerrold M. Olefsky

  • The cellular and signaling networks linking the immune system and metabolism in disease

    Olivia Osborn;Jerrold M Olefsky

  • Insulin sensitivity: modulation by nutrients and inflammation.

    Simon Schenk;Maziyar Saberi;Jerrold M. Olefsky

  • Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

    Alan R Saltiel;Jerrold M Olefsky

  • Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity

    Utpal B. Pajvani;Meredith Hawkins;Terry P. Combs;Michael W. Rajala

  • Inflammation and Insulin Resistance

    Carl de Luca;Jerrold M. Olefsky

  • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways.

    M. T. Audrey Nguyen;Svetlana Favelyukis;Anh-Khoi Nguyen;Donna Reichart

  • Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone.

    John J. Nolan;Bernhard Ludvik;Patricia Beerdsen;Mary Joyce

  • Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle.

    Weimin He;Yaacov Barak;Andrea Hevener;Peter Olson

  • Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro.

    Jerzy W Kolaczynski;Mark R Nyce;Robert V Considine;Guenther Boden

  • Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

    Christopher K. Glass;Jerrold M. Olefsky

  • The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects

    Joseph G. Yu;Sandrine Javorschi;Andrea L. Hevener;Yolanta T. Kruszynska

  • Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity.

    Wei Ying;Matthew Riopel;Gautam Bandyopadhyay;Yi Dong

  • Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

    Saswata Talukdar;Da Young Oh;Gautam Bandyopadhyay;Dongmei Li

  • Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.

    Richard N. Bergman;Rudy Prager;Aage Volund;Jerrold M. Olefsky

  • Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity

    Ying W;Riopel M;Bandyopadhyay G;Dong Y

Frequent Co-Authors

Gerald M. Reaven
Gerald M. Reaven Stanford University
Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Nicholas J. G. Webster
Nicholas J. G. Webster University of California, San Diego
Alan R. Saltiel
Alan R. Saltiel University of California, San Diego
Robert R. Henry
Robert R. Henry University of California, San Diego
Donald A. McClain
Donald A. McClain Wake Forest University
David W. Rose
David W. Rose University of California, San Diego
Kim A. Heidenreich
Kim A. Heidenreich University of Colorado Denver
Michael Downes
Michael Downes Salk Institute for Biological Studies
Ruth T. Yu
Ruth T. Yu Salk Institute for Biological Studies

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