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Genetics and Molecular Biology
France
2024

D-Index & Metrics

Molecular Biology

D-Index
77
Citations
36134
World Ranking
1092
National Ranking
32

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in France Leader Award

Overview

Philippe Kastner is affiliated with the Institute of Genetics and Molecular and Cellular Biology in France. Their research spans several fields, primarily focused on Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology.

Their main research areas include Acute Lymphoblastic Leukemia research, Immune Cell Function and Interaction, CAR-T cell therapy research, T-cell and B-cell Immunology, Chronic Lymphocytic Leukemia Research, Childhood Cancer Survivors' Quality of Life, and Epigenetics and DNA Methylation.

Frequent publication venues for Kastner's work include PLoS ONE, Biochemical and Biophysical Research Communications, Proceedings of the National Academy of Sciences, The Journal of Experimental Medicine, and Science Immunology.

They have collaborated frequently with several co-authors, including:

  • Susan Chan (11 publications)
  • Patricia Marchal (5 publications)
  • Beate Heizmann (4 publications)
  • Stéphanie Le Gras (4 publications)
  • Célestine Simand (3 publications)

Selected recent papers authored or co-authored by Kastner illustrate key themes in their research:

  • "CD4+T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate" (2021), published in Proceedings of the National Academy of Sciences
  • "Ikaros antagonizes DNA binding by STAT5 in pre-B cells" (2020), published in PLoS ONE
  • "Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells" (2021), published in The Journal of Experimental Medicine
  • "CD4+ regulatory T cells lacking Helios and Eos" (2023), published in Biochemical and Biophysical Research Communications
  • "Ikaros is a principal regulator of Aire + mTEC homeostasis, thymic mimetic cell diversity, and central tolerance" (2023), published in Science Immunology

Best Publications

  • The nuclear receptor superfamily: the second decade.

    David J. Mangelsdorf;Carl Thummel;Miguel Beato;Peter Herrlich

  • Two distinct estrogen‐regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

    P Kastner;A Krust;B Turcotte;U Stropp

  • Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

    Philippe Kastner;Manuel Mark;Pierre Chambon

  • Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently

    Mark Leid;Mark Leid;Philippe Kastner;Philippe Kastner;Ruth Lyons;Ruth Lyons;Harikrishna Nakshatri;Harikrishna Nakshatri

  • Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

    Arthur Zelent;Andrée Krust;Martin Petkovich;Philippe Kastner

  • Multiplicity generates diversity in the retinoic acid signalling pathways

    Mark Leid;Philippe Kastner;Pierre Chambon

  • Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids

    G Allenby;M T Bocquel;M Saunders;S Kazmer

  • A third human retinoic acid receptor, hRAR-gamma

    A. Krust;Ph. Kastner;M. Petkovich;A. Zelent

  • Function of retinoic acid receptor γ in the mouse

    David Lohnes;Philippe Kastner;Philippe Kastner;Andrée Dierich;Andrée Dierich;Manuel Mark;Manuel Mark

  • Genetic analysis of RXRα developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis

    Philippe Kastner;Jesus M. Grondona;Jesus M. Grondona;Manuel Mark;Manuel Mark;Anne Gansmuller;Anne Gansmuller

  • Fuzzy C-means method for clustering microarray data

    Doulaye Dembélé;Philippe Kastner

  • Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse.

    Pascal Dollé;Esther Ruberte;Philippe Kastner;Martin Petkovich

  • Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

    Scott H Robbins;Thierry Walzer;Thierry Walzer;Doulaye Dembélé;Christelle Thibault

  • Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.

    P. Kastner;A. Perez;Y. Lutz;C. Rochette-Egly

  • Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.

    Hiromi Iwasaki;Chamorro Somoza;Hirokazu Shigematsu;Estelle A. Duprez

  • Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.

    P. Leroy;A. Krust;A. Zelent;C. Mendelsohn

  • Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing.

    A. Zelent;C. Mendelsohn;P. Kastner;A. Krust

  • Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development

    Philippe Kastner;Manuel Mark;Norbert Ghyselinck;Wojciech Krezel

  • Developmental expression of murine retinoid X receptor (RXR) genes

    Pascal Dollé;Valérie Fraulob;Philippe Kastner;Pierre Chambon

  • Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

    Sunil Nagpal;Sunil Nagpal;Michael Saunders;Michael Saunders;Philippe Kastner;Philippe Kastner;Béatrice Durand;Béatrice Durand

Frequent Co-Authors

Susan Chan
Susan Chan Institute of Genetics and Molecular and Cellular Biology
Pierre Chambon
Pierre Chambon Institute of Genetics and Molecular and Cellular Biology
Manuel Mark
Manuel Mark Institute of Genetics and Molecular and Cellular Biology
Andrée Dierich
Andrée Dierich Institute of Genetics and Molecular and Cellular Biology
Norbert B. Ghyselinck
Norbert B. Ghyselinck Institute of Genetics and Molecular and Cellular Biology
Mark Leid
Mark Leid Oregon State University
Koichi Akashi
Koichi Akashi Kyushu University
Marianne LeMeur
Marianne LeMeur Institute of Genetics and Molecular and Cellular Biology
Cathy Mendelsohn
Cathy Mendelsohn Columbia University
Andrée Krust
Andrée Krust Collège de France

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