World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
140
Citations
109816
World Ranking
266
National Ranking
182

Research.com Recognitions

  • 2008 - Member of the National Academy of Sciences

Overview

David J. Mangelsdorf is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research spans multiple fields within Biochemistry, Genetics and Molecular Biology, as well as Medicine.

The scientist's main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields of study in which they have published work include:

  • Molecular Biology
  • Parasitology
  • Physiology
  • Small Animals
  • Ecology

The primary research topics covered by David J. Mangelsdorf consist of:

  • Parasites and Host Interactions
  • Fibroblast Growth Factor Research
  • Kruppel-like factors research
  • Epigenetics and DNA Methylation
  • Adipose Tissue and Metabolism
  • Helminth infection and control
  • Parasite Biology and Host Interactions

The scientist's frequent co-authors include:

  • Steven A. Kliewer
  • James B. Lok
  • Kevin Vale
  • Mi Cheong Cheong
  • Zhu Wang

David J. Mangelsdorf has published in several notable venues, including:

  • Proceedings of the National Academy of Sciences
  • American Journal of Clinical Nutrition
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Cell Metabolism

Selected recent publications by the scientist include:

  • The energy balance model of obesity: beyond calories in, calories out, 2022, American Journal of Clinical Nutrition
  • FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes, 2021, Cell Reports
  • Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy, 2020, Science Translational Medicine
  • FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system, 2023, Cell Metabolism
  • Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite Strongyloides stercoralis, 2021, Proceedings of the National Academy of Sciences

David J. Mangelsdorf has been recognized as a Member of the National Academy of Sciences since 2008.

Best Publications

  • The nuclear receptor superfamily: the second decade.

    David J. Mangelsdorf;Carl Thummel;Miguel Beato;Peter Herrlich

  • The RXR heterodimers and orphan receptors

    David J. Mangelsdorf;Ronald M. Evans

  • Identification of a Nuclear Receptor for Bile Acids

    Makoto Makishima;Arthur Y. Okamoto;Joyce J. Repa;Hua Tu

  • An oxysterol signalling pathway mediated by the nuclear receptor LXRα

    Bethany A. Janowski;Patricia J. Willy;Thota Rama Devi;J. R. Falck

  • Nuclear receptors and lipid physiology: opening the X-files.

    Ajay Chawla;Joyce J. Repa;Ronald M. Evans;David J. Mangelsdorf

  • 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

    Richard A. Heyman;David J. Mangelsdorf;Jacqueline A. Dyck;Jacqueline A. Dyck;Robert B. Stein

  • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

    Joyce J. Repa;Guosheng Liang;Jiafu Ou;Yuriy Bashmakov

  • Role of LXRs in control of lipogenesis

    Joshua R. Schultz;Hua Tu;Alvin Luk;Joyce J. Repa

  • Nuclear receptor that identifies a novel retinoic acid response pathway

    David J. Mangelsdorf;Estelita S. Ong;Jacqueline A. Dyck;Ronald M. Evans

  • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

    Takeshi Inagaki;Mihwa Choi;Antonio Moschetta;Li Peng

  • Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

    S A Kliewer;B M Forman;B Blumberg;E S Ong

  • Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

    Daniel J. Peet;Stephen D Turley;Wenzhen Ma;Bethany A. Janowski

  • Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

    Takeshi Inagaki;Paul Dutchak;Guixiang Zhao;Xunshan Ding

  • Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

    Steven A. Kliewer;Kazuhiko Umesono;Kazuhiko Umesono;David J. Mangelsdorf;Ronald M. Evans;Ronald M. Evans

  • Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.

    Timothy T. Lu;Makoto Makishima;Joyce J. Repa;Kristina Schoonjans

  • Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

    Joyce Repa;Stephen D Turley;J. M A Lobaccaro;J. Medina

  • LXR, a nuclear receptor that defines a distinct retinoid response pathway.

    Patricia J. Willy;Kazuhiko Umesono;Estelita S. Ong;Ronald M. Evans

  • Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

    D J Mangelsdorf;U Borgmeyer;R A Heyman;J Y Zhou;J Y Zhou

  • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

    Peter J. Tontonoz;Sean B. Joseph;Antonio Castrillo

  • Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.

    Mitsuhiro Watanabe;Sander M. Houten;Li Wang;Antonio Moschetta

Frequent Co-Authors

Steven A. Kliewer
Steven A. Kliewer The University of Texas Southwestern Medical Center
Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Joyce J. Repa
Joyce J. Repa The University of Texas Southwestern Medical Center
John D. Minna
John D. Minna The University of Texas Southwestern Medical Center
Mark R. Haussler
Mark R. Haussler University of Arizona
Makoto Makishima
Makoto Makishima Nihon University
Yang Xie
Yang Xie The University of Texas Southwestern Medical Center
Luc Girard
Luc Girard The University of Texas Southwestern Medical Center
Kazuhiko Umesono
Kazuhiko Umesono Kyoto University
Johan Auwerx
Johan Auwerx École Polytechnique Fédérale de Lausanne

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing Biology and Biochemistry in the USA opens a variety of education and career options, including innovative online programs and specialized career certifications. Many students looking for flexibility in their schedule opt for the fastest nutrition degree online. Such programs allow you to efficiently gain specialized knowledge in nutrition, which complements a background in biology or biochemistry.

If you are interested in leadership roles within healthcare, consider the cheapest online mba healthcare management. This pathway can significantly broaden your career prospects, offering valuable business and managerial skills tailored to the healthcare industry.

Alternatively, medical coding offers a technical yet vital function in the healthcare field. Understanding the differences between certified professional coder certifications can help you select the right credential for your goals and maximize your salary prospects. Additionally, learning medical coding jobs salary and training requirements helps you make informed decisions about entering this in-demand profession.

Best Scientists Citing David J. Mangelsdorf

Trending Scientists