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D-Index & Metrics

Biology and Biochemistry

D-Index
120
Citations
88903
World Ranking
619
National Ranking
395

Research.com Recognitions

  • 2015 - Member of the National Academy of Sciences

Overview

Steven A. Kliewer is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research spans several areas within biochemistry, genetics, molecular biology, immunology, and microbiology.

Their recent publications cover a range of topics related to fibroblast growth factors, parasitology, and signaling pathways. Notable papers include:

  • FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes (2021, Cell Reports)
  • Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy (2020, Science Translational Medicine)
  • FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system (2023, Cell Metabolism)
  • Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite Strongyloides stercoralis (2021, Proceedings of the National Academy of Sciences)
  • Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis (2021, eLife)

Their frequent co-authors include:

  • David J. Mangelsdorf (15 joint publications)
  • James B. Lok (5 joint publications)
  • Kevin Vale (4 joint publications)
  • Mi Cheong Cheong (4 joint publications)
  • Zhu Wang (4 joint publications)

Steven A. Kliewer's work is published often in several venues, with multiple contributions to:

  • Proceedings of the National Academy of Sciences (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (2 publications)
  • Cell Reports
  • Cell Metabolism
  • Science Translational Medicine

Their main fields of study are:

  • Biochemistry, Genetics and Molecular Biology (22 publications)
  • Immunology and Microbiology (8 publications)

Subfields include:

  • Molecular Biology (19 publications)
  • Parasitology (7 publications)
  • Small Animals (2 publications)
  • Ecology (2 publications)
  • Pathology and Forensic Medicine (2 publications)

The primary topics of research focus on:

  • Parasites and Host Interactions (14 publications)
  • Fibroblast Growth Factor Research (12 publications)
  • Kruppel-like factors research (12 publications)
  • Epigenetics and DNA Methylation (8 publications)
  • Helminth infection and control (4 publications)
  • Parasite Biology and Host Interactions (4 publications)
  • Genetics, Aging, and Longevity in Model Organisms (4 publications)

Steven A. Kliewer was elected a Member of the National Academy of Sciences in 2015.

Best Publications

  • An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

    Jürgen M. Lehmann;Linda B. Moore;Tracey A. Smith-Oliver;William O. Wilkison

  • Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

    Steven A. Kliewer;Scott S. Sundseth;Stacey A. Jones;Peter J. Brown

  • A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

    Steven A. Kliewer;James M. Lenhard;Timothy M. Willson;Inder Patel

  • Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

    Derek J. Parks;Steven G. Blanchard;Randy K. Bledsoe;Gyan Chandra

  • Convergence of 9- cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

    Steven A. Kliewer;Kazuhiko Umesono;Daniel J. Noonan;Richard A. Heyman

  • A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

    Bryan Goodwin;Stacey A. Jones;Roger R. Price;Michael A. Watson

  • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

    Jürgen M. Lehmann;David D. McKee;Michael A. Watson;Timothy M. Willson

  • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

    Takeshi Inagaki;Mihwa Choi;Antonio Moschetta;Li Peng

  • An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

    Steven A Kliewer;John T Moore;Laura Wade;Jeff L Staudinger

  • Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

    S A Kliewer;B M Forman;B Blumberg;E S Ong

  • Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

    Takeshi Inagaki;Paul Dutchak;Guixiang Zhao;Xunshan Ding

  • Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

    Steven A. Kliewer;Kazuhiko Umesono;Kazuhiko Umesono;David J. Mangelsdorf;Ronald M. Evans;Ronald M. Evans

  • Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

    Jürgen M. Lehmann;James M. Lenhard;Beverly B. Oliver;Gordon M. Ringold

  • The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

    Jeffrey Leonard Staudinger;Jeffrey Leonard Staudinger;Bryan Goodwin;Stacey A. Jones;Diane Hawkins-Brown

  • Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

    Jürgen M. Lehmann;Steven A. Kliewer;Linda B. Moore;Tracey A. Smith-Oliver

  • Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

    Roland Schüle;Pundl Rangarajan;Steven A Kliewer;Lynn J. Ransone

  • Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors

    H.Eric Xu;Millard H Lambert;Valerie G Montana;Derek J Parks

  • A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

    William R. Oliver;Jennifer L. Shenk;Mike R. Snaith;Caroline S. Russell

  • Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.

    B. A. Janowski;M. J. Grogan;S. A. Jones;G. B. Wisely

  • The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.

    Steven A. Kliewer;Bryan Goodwin;Timothy M. Willson

Frequent Co-Authors

David J. Mangelsdorf
David J. Mangelsdorf The University of Texas Southwestern Medical Center
Timothy M. Willson
Timothy M. Willson University of North Carolina at Chapel Hill
Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
H. Eric Xu
H. Eric Xu Chinese Academy of Sciences
Millard H. Lambert
Millard H. Lambert GlaxoSmithKline (United Kingdom)
Kazuhiko Umesono
Kazuhiko Umesono Kyoto University
Matthew R. Redinbo
Matthew R. Redinbo University of North Carolina at Chapel Hill
Moosa Mohammadi
Moosa Mohammadi New York University Langone Medical Center
Robert D. Gerard
Robert D. Gerard The University of Texas Southwestern Medical Center
Shawn C. Burgess
Shawn C. Burgess The University of Texas Southwestern Medical Center

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